<i>Helicobacter pylori</i> infection among children with gastrointestinal symptoms: a high prevalence of infection among patients with reflux oesophagitis

Daugule, Ilva; Rumba, I.; Alksnis, J; Ejderhamn, Jan

doi:10.1111/j.1651-2227.2007.00329.x

Cited by 24 publications

(24 citation statements)

References 20 publications

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“…Similar to our findings of an increased prevalence of RE in H. pylori positive patients, Daugule et al (24) showed that the prevalence of H. pylori was significantly higher among children with RE than in children with hyperemic gastropathy. We also found that H. pylori infection was more closely associated with RE in younger children (0–10 years) than in older children (> 10 years), although this may be related to an age specific distribution of H. pylori gastritis.…”

Section: Discussionsupporting

confidence: 92%

“…There are limited data regarding the relationship between H. pylori infection and GERD in the pediatric population (21–24). Levine et al .…”

Section: Introductionmentioning

confidence: 99%

“…Özçay et al . (23) found no significant difference in reflux esophgitis (RE) between children with and without H. pylori infection while Daugule et al (24) showed a significantly higher prevalence of H. pylori in children with RE compared to children with hyperemic gastropathy.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Positive Association Between Helicobacter pylori and Gastroesophageal Reflux Disease in Children

Moon

Solomon²,

Beneck³

et al. 2009

J. pediatr. gastroenterol. nutr.

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Objectives-The role of Helicobacter pylori (H. pylori) in gastroesophageal reflux disease (GERD) remains controversial, particularly in children, since there are limited published data. Adult studies suggested that H. pylori infection may protect against GERD by causing atrophic gastritis, which leads to reduced gastric acid secretion. The objective of our study was to determine the role of H. pylori infection in the development of GERD in a pediatric population.Methods-A retrospective analysis of 420 patients (M:F = 214:206) who underwent esophagogastroduodenoscopy (EGD) with biopsies between January 2000 and April 2006 was conducted. Patient demographics, clinical indications for EGD and the prevalence of reflux esophagitis (RE), the biomarker for GERD, in two groups, H. pylori positive and H. pylori negative, were reviewed. The prevalence of RE in the H. pylori positive and H. pylori negative groups was further analyzed based on gender and age (< 1 yr, 1 -10 yrs, > 10 yrs). The mean age of the study population was 8.2 years (range 0 -20 yrs). The clinical indications for EGD were as follows: recurrent abdominal pain (n = 186, 44%), malabsorption (n = 80, 19%), persistent vomiting (n = 80, 19%), suspected eosinophilic gastrointestinal disorders (n = 63, 15%) and others such as upper GI bleeding or IBD surveillance (n = 11, 3%). Statistical analysis was performed by using Chi-square test, Fisher's exact test and multivariate logistical regression analysis.Results-Among the 420 patients, 16 patients (3.8%) were positive for H. pylori and 167 patients (39.8%) were found to have RE. Thirteen patients with H. pylori were found to have histologic evidence of RE. The prevalence of RE in the H. pylori positive population was 81.3% compared to 38.1% in the H. pylori negative population (p ≤ 0.05). There were no patients with H. pylori in the youngest age group. In the second age group (1-10 yrs), 100% of the H. pylori positive patients had RE while 44.6% of the H. pylori negative patients had RE (p ≤ 0.05). Both male and female patients with H. pylori had a higher prevalence of RE, 77.8% and 85.7% respectively. On a multivariate logistical regression, for the overall study cohort, H. pylori positive patients had an odds ratio of 5.79 of developing RE compared to H. pylori negative patients (p ≤ 0.05).Conclusions-Our study results indicate that there is a significantly higher prevalence of RE in an H. pylori-infected cohort independent of age or gender. The findings suggest that H. pylori infection in children is positively associated with RE.

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Section: Discussionsupporting

confidence: 92%

“…There are limited data regarding the relationship between H. pylori infection and GERD in the pediatric population (21–24). Levine et al .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Positive Association Between Helicobacter pylori and Gastroesophageal Reflux Disease in Children

Moon

Solomon²,

Beneck³

et al. 2009

J. pediatr. gastroenterol. nutr.

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“…The risk of harboring H. pylori Ag was increased with age above 5 years who having burning sensation and unprotected water source. A large body of evidence shows that the prevalence of H. pylori was significantly higher among children with reflux oesophagitis than in children with hyperemic gastropathy [31] . However, we could not find any significant difference between H. pylori positive and negative cases in the incidence of nausea, and vomiting [32] , or diarrhea [33] .…”

Section: Patientsmentioning

confidence: 99%

Correlation of Helicobacter Pylori Infection With IL-8 and Recurrence of Abdominal Pain: Our Experience from an Endemic Area

Mohamed¹,

Mina

Tosson

et al. 2016

Journal of Gastroenterology and Hepatology Research

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“…Baltijos regione (Estijoje, Latvijoje, Lietuvoje) H. pylori paplitimas vaikų populiacijoje svyruoja nuo 18 iki 55 proc. [7,8]. Lietuvoje 1999 m. paplitimas tarp tirtų 10-14 metų vaikų sudarė 25-55 proc., 2012 m. tarp medicinos studentų paplitimas sudarė 25 proc.…”

Section: Diskusijaunclassified

Helicobacter pylori atsparumas antibiotikams vaikų amžiuje

Aužbikienė

Kirslienė

Sakalinskienė

et al. 2015

Medicinos Teorija Ir Praktika

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Reikšminiai žodžiai: H. pylori, atsparumas antibiotikams, vaikai. Daugelyje šalių pastebimas didėjantis Helicobacter pylori (H. pylori) atsparumas antibiotikams, ypač vaikų amžiuje. Tai nulemta augančio antibiotikų vartojimo. Darbo tikslas. Nustatyti Helicobacter pylori pirminį atsparumą antibiotikams Lietuvoje, gautus rezultatus palyginti su seniau atliktais tyrimais. Tyrimo medžiaga ir metodai. Į tyrimą įtraukti nuo 2013 metų rugsėjo iki 2015 metų balandžio Vaikų ligoninėje, VšĮ Vilniaus universiteto ligoninės Santariškių klinikų filiale (toliau – Vaikų ligoninė) gydyti vaikai. Atrankos kriterijai: vaikai, besiskundžiantys pilvo skausmu, dispepsija ar nustatyta neaiškios kilmės anemija; atlikta fibrogastroskopija ir gautas teigiamas ureazės testas, anksčiau netaikyta H.pylori eradikacija. Biopsijos buvo paimtos iš 137 pacientų (80 mergaičių ir 57 berniukų). Biopsijos medžiaga buvo išsėta į arklio kraujo agaro terpę ir auginama 35–37°C mikroaerobinėmis sąlygomis 4–7 dienas. Atlikti E-testai amoksicilinui (minimali slopinanti koncentracija (MIC) ≥0,125 mg/l), klaritromicinui (MIC ≥ 0,5 mg/l), metronidazoliui (MIC ≥ 8 mg/l) ir levofloksacinui (MIC ≥1 mg/l). Rezultatai. Iš 137 pasėlių augimas buvo stebimas 82 atvejais (60,4 proc.). Atsparumas vienam ar keliems antibiotikams nustatytas 41 pasėlyje. Atsparumas klaritromicinui buvo 33 (40,2 proc., metronidazoliui – 18 (22 proc.), levofloksacinui 2 (2,4 proc.), klaritromicino ir metronidazolio deriniui – 11 (13,4 proc.) atvejų. Amoksicilinui atsparumo nebuvo pastebėta. Rezultatai palyginti su 2007–2008 m. Lietuvoje atliktu tyrimu [4]: atsparumas klaritromicinui padidėjo nuo 16,8 proc. iki 40,2 proc. (p<0,05), metronidazoliui – nuo 20,7 proc. iki 22 proc. (p=0,88), abiejų vaistų deriniui nuo 4,2 proc. iki 13,4 proc. (p=0,089). Išvados. Nuo 2007–2008 m. iki 2013–2015 m. H. pylori atsparumas klaritromicinui padidėjo 2,4 kartus, o metronidazoliui padidėjo statistiškai nereikšmingai. Stebėti pavieniai atsparumo levofloksacinui atvejai, amoksicilinui atsparumo nebuvo. Padidėjęs atsparumas klaritromicinui gali būti susijęs su padidėjusiu klaritromicino suvartojimu šalyje.

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Helicobacter pylori infection among children with gastrointestinal symptoms: a high prevalence of infection among patients with reflux oesophagitis

Cited by 24 publications

References 20 publications

Positive Association Between Helicobacter pylori and Gastroesophageal Reflux Disease in Children

Positive Association Between Helicobacter pylori and Gastroesophageal Reflux Disease in Children

Correlation of Helicobacter Pylori Infection With IL-8 and Recurrence of Abdominal Pain: Our Experience from an Endemic Area

Helicobacter pylori atsparumas antibiotikams vaikų amžiuje

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