<i>Helicobacter pylori</i> Infection in Children: Nutritional Status and Associations with Serum Leptin, Ghrelin, and <scp>IGF</scp>‐1 Levels

Erdemir, Gulin; Özkan, Tanju; Özgür, Taner; Altay, Derya; Çavun, Sinan; Göral, Güher

doi:10.1111/hel.12288

Cited by 18 publications

(17 citation statements)

References 40 publications

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“…Serum leptin, ghrelin, and IGF‐1 levels were not associated with H. pylori IgG seropositivity. The authors conclude that children infected with H. pylori are prone to short stature, but this effect seems to be independent of neuroendocrine hormones . However, different results were found in 178 Mexican schoolchildren.…”

Section: Clinical Manifestationsmentioning

confidence: 81%

Helicobacter pylori infection in children

2017

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Helicobacter pylori infection in children differs from that in adults, from the point of view of epidemiology, host response, clinical features, related diseases, and diagnosis, as well as treatment strategies. The prevalence of H. pylori infection, in both children and adults, is decreasing in the Western World as well as in some developing countries, which contrasts with the increase in childhood asthma and allergic diseases. Recurrent abdominal pain is not specific during H. pylori infection in children. The role of H. pylori infection and failure to thrive, children's growth, type I diabetes mellitus (T1DM) and celiac disease remains controversial. The main initial diagnosis is based on upper digestive endoscopy with biopsy-based methods. Nodular gastritis may be a pathognomonic endoscopic finding of childhood H. pylori infection. The infection eradication control is based on validated noninvasive tests. The main cause of treatment failure of H. pylori infection is its clarithromycin resistance. We recommend standard antibiotic susceptibility testing of H. pylori in pediatric patients prior to the initiation of eradication therapy. H. pylori treatment in children should be based on an evaluation of the rate of eradication in the local population, a systematic use of a treatment adapted to the susceptibility profile and a treatment compliance greater than 90%. The last meta-analysis in children did not show an advantage for sequential therapy when compared to a 14-day triple therapy. Finally, the high rate of antibiotic resistance responsible for therapy failure in recent years justifies the necessity of a novel vaccine to prevent H. pylori infection in children.

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Section: Clinical Manifestationsmentioning

confidence: 81%

Helicobacter pylori infection in children

2017

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“…Whereas leptin which is secreted by gastric epithelium and adipose tissue, reflects body fat stores, and stabilizes body weight by suppressing food intake and increasing energy consumption. 19 Besides the impact of these two peptide hormones on appetite, proinflammatory characteristics of these hormones were also reported in human and animal studies. [20][21][22][23] Both hormones are associated with the production of proinflammatory cytokines such as TNF-a and IL-1b.…”

Section: Discussionmentioning

confidence: 92%

Cytokines, adipocytokines and inflammatory markers in patients on continuous ambulatory peritoneal dialysis and hemodialysis

Oncel

Akbulut²,

Özer

et al. 2016

Renal Failure

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“…Serum leptin, ghrelin, and IGF‐1 levels were measured by Erdemir et al . in 67 H. pylori seropositive and 94 seronegative children, without finding any significant difference between groups.…”

Section: Clinical Presentationmentioning

confidence: 99%

Helicobacter pylori in children

2016

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Helicobacter pylori infection in early childhood may differ in many aspects compared to infection in adulthood: the immune response in the gut, the type and prevalence of complications within and outside the stomach, and the impact on long-term health. In high prevalence countries, transient infections seem to be common in infants and toddlers, and the consequences of this phenomenon on the short- and long-term immune response are still unclear. Other controversial issues are related to the question of which H. pylori-infected children benefit from treatment and which is the best regimen to eradicate the infection in the presence of a worldwide increasing antibiotic resistance. The first large-scale randomized placebo-controlled vaccination trial in schoolchildren indicates that prevention of the infection may be possible.

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Helicobacter pylori Infection in Children: Nutritional Status and Associations with Serum Leptin, Ghrelin, and IGF‐1 Levels

Abstract: Children infected with H. pylori are prone to short stature. This effect seems to be independent of neuroendocrine hormones.

Cited by 18 publications

References 40 publications

Helicobacter pylori infection in children

Helicobacter pylori infection in children

Cytokines, adipocytokines and inflammatory markers in patients on continuous ambulatory peritoneal dialysis and hemodialysis

Helicobacter pylori in children

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