<i>Helicobacter pylori</i> infection in psoriasis: results of a clinical study and review of the literature

Campanati, Anna; Ganzetti, Giulia; Martina, Emanuela; Giannoni, Melania; Gesuita, Rosaria; Bendia, E.; Giuliodori, Katia; Sandroni, Lucia; Offidani, Annamaria

doi:10.1111/ijd.12798

Cited by 23 publications

(21 citation statements)

References 33 publications

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“…However, the role of H. pylori in the pathogenesis of some dermatological diseases has been also questioned (Kutlubay et al 2014; Magen and Delgado 2014). Patients with mild to severe psoriasis were not found to be more susceptible to H. pylori infection; however, H. pylori affected the clinical severity of psoriasis (Campanati et al 2015). H. pylori eradication was reported to have no discernible effect on chronic spontaneous urticaria (CSU) beyond that of standard CSU therapy (Curth et al 2015).…”

Section: H Pylori Infection and Systematic Diseasesmentioning

confidence: 99%

Helicobacter pylori-induced premature senescence of extragastric cells may contribute to chronic skin diseases

Lewińska

Wnuk

2017

Biogerontology

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Helicobacter pylori, one of the most frequently observed bacterium in the human intestinal flora, has been widely studied since Marshall and Warren documented a link between the presence of H. pylori in the gastrointestinal tract and gastritis and gastric ulcers. Interestingly, H. pylori has also been found in several other epithelial tissues, including the eyes, ears, nose and skin that may have direct or indirect effects on host physiology and may contribute to extragastric diseases, e.g. chronic skin diseases. More recently, it has been shown that H. pylori cytotoxin CagA expression induces cellular senescence of human gastric nonpolarized epithelial cells that may lead to gastrointestinal disorders and systemic inflammation. Here, we hypothesize that also chronic skin diseases may be promoted by stress-induced premature senescence (SIPS) of skin cells, namely fibroblasts and keratinocytes, stimulated with H. pylori cytotoxins. Future studies involving cell culture models and clinical specimens are needed to verify the involvement of H. pylori in SIPS-based chronic skin diseases.

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Section: H Pylori Infection and Systematic Diseasesmentioning

confidence: 99%

Helicobacter pylori-induced premature senescence of extragastric cells may contribute to chronic skin diseases

Lewińska

Wnuk

2017

Biogerontology

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“… 56 – 58 In addition, several researchers have observed an association between disease severity as measured by PASI with status regarding infection with Helicobacter pylori . 59 – 61 Given the relationship of these infections and psoriasis, the exotoxins of these microorganisms as well as peptidoglycans derived from bacterial sources have been reported as possible candidates for activating T cells and leading to psoriasis development through an abnormal immunological response. 62 – 65 …”

Section: Potential Causes/triggers Of Psoriasismentioning

confidence: 99%

Current knowledge on psoriasis and autoimmune diseases

Ayala-Fontánez¹,

Soler²,

McCormick³

2016

PTT

121

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Psoriasis is a prevalent, chronic inflammatory disease of the skin, mediated by crosstalk between epidermal keratinocytes, dermal vascular cells, and immunocytes such as antigen presenting cells (APCs) and T cells. Exclusive cellular “responsibility” for the induction and maintenance of psoriatic plaques has not been clearly defined. Increased proliferation of keratinocytes and endothelial cells in conjunction with APC/T cell/monocyte/macrophage inflammation leads to the distinct epidermal and vascular hyperplasia that is characteristic of lesional psoriatic skin. Despite the identification of numerous susceptibility loci, no single genetic determinant has been identified as responsible for the induction of psoriasis. Thus, numerous other triggers of disease, such as environmental, microbial and complex cellular interactions must also be considered as participants in the development of this multifactorial disease. Recent advances in therapeutics, especially systemic so-called “biologics” have provided new hope for identifying the critical cellular targets that drive psoriasis pathogenesis. Recent recognition of the numerous co-morbidities and other autoimmune disorders associated with psoriasis, including inflammatory bowel disease, multiple sclerosis, rheumatoid arthritis, and systemic lupus erythematosus suggest common signaling elements and cellular mediators may direct disease pathogenesis. In this review, we discuss common cellular pathways and participants that mediate psoriasis and other autoimmune disorders that share these cellular signaling pathways.

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“…Whereas Campanati et al . [ 20 ] included participants with GI complaints, the authors did not compare the number of patients and controls with different GI symptoms. The authors did report that the percentage of epigastric pain (27.5% vs. 13.9%), and heartburn (25% vs. 10.8%) were higher in psoriasis patients with H. pylori positive than those patients with H. pylori negative on urea breath test.…”

Section: Resultsmentioning

confidence: 99%

“…No difference in symptoms of dyspepsia, bloating, diarrhea, constipation, and weight loss in both H. pylori positive and negative psoriasis patient groups. [ 20 ] Türkmen et al . [ 21 ] included participants with GI symptoms; however, there was no statistically significant difference in between psoriasis and control groups.…”

Section: Resultsmentioning

confidence: 99%

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Association between psoriasis and Helicobacter pylori infection: A systematic review and meta-analysis

2018

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Helicobacter pylori infection in psoriasis: results of a clinical study and review of the literature

Abstract: Patients with mild to severe psoriasis do not show a greater prevalence of H. pylori infection; however, H. pylori seems able to affect the clinical severity of psoriasis.

Cited by 23 publications

References 33 publications

Helicobacter pylori-induced premature senescence of extragastric cells may contribute to chronic skin diseases

Helicobacter pylori-induced premature senescence of extragastric cells may contribute to chronic skin diseases

Current knowledge on psoriasis and autoimmune diseases

Association between psoriasis and Helicobacter pylori infection: A systematic review and meta-analysis

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