<i>Helicobacter pylori</i> infection is associated with colon adenomatous polyps detected by high‐resolution colonoscopy

Mizuno, Shigeto; Morita, Yoshinori; Inui, Toshio; Asakawa, Akihiro; Ueno, Naohiko; Ando, Takashi; Kato, Hitoshi; Uchida, Masaya; Yoshikawa, Toshikazu; Inui, Akio

doi:10.1002/ijc.21280

Cited by 56 publications

(67 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Even though there were several reports that H pylori infection increased the risk of colorectal adenoma and adenocarcinoma [7][8][9] , our report reveals that H pylori infection is not a risk factor for advanced colorectal polyps, but that gastric dysplasia and an advanced age are. Thus, we infer that genetic and environmental factors probably importantly contribute to the development of advanced colorectal polyps, because patients are continuously exposed to those factors.…”

Section: Discussioncontrasting

confidence: 79%

“…Several other controversial factors may increase the risk of colorectal cancer development, e.g. an increased serum gastrin level [35] , H pylori infection [6][7][8][9][10][11] and Streptococcus bovis bacteremia [36] . However, previous studies have concluded that the presence of H pylori infection and an elevated serum gastrin level are not associated with elevated risks of colorectal neoplasm development.…”

Section: Discussionmentioning

confidence: 99%

“…The etiologies and risk factors of colorectal neoplasms have attracted research attention for several decades, especially in association with Helicobacter pylori (H pylori) or gastric dysplasia. H pylori infection is a well-known cause of chronic gastritis, peptic ulcers [3,4] , gastric adenocarcinoma [5] , and gastric lymphoma [6] , and several reports have suggested that H pylori infection increases the risk of colorectal adenoma and adenocarcinoma [7][8][9] ; however, other reports disagree [10,11] . Furthermore, several have concluded that gastric adenoma and carcinoma may be indicators of colorectal adenoma or carcinoma [12,13] , and it is accepted that both gastric adenoma and colorectal adenoma have a high potential for malignant transformation [14][15][16] .…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Gastric dysplasia may be an independent risk factor of anadvanced colorectal neoplasm

Bae¹,

Jeon²,

Cho³

et al. 2009

WJG

View full text Add to dashboard Cite

AIM:To evaluate the relationship between gastric dysplasia and Helicobacter pylori (H pylori ) and the occurrence of colorectal adenoma, and to define the necessity for colonoscopy in patients with gastric dysplasia or H pylori infection. May 2005 to February 2008, 133 patients with established gastric dysplasia by gastroduo denoscopy (EGD) were additionally investigated by colonoscopy. The authors compared results with those of 213 subjects who underwent both EGD and colonoscopy during the same period at the author's Health Promotion Center as a control group. H pylori infection was evaluated in both the gastric dysplasia and control groups. METHODS: From RESULTS:The mean age of all 346 study subjects was 54.1 ± 10.5 years, and there were 258 (73%) men and 87 (27%) women. No significant difference was found between the H pylori positive and negative subjects in terms of the prevalence of colorectal adenoma and advanced colorectal adenoma (P = 0.261). Patients with gastric dysplasia showed no elevated risk of colorectal adenoma (OR = 0.910, 95% CI: 0.5871.411, P = 0.738), but had a significantly higher risk of having advanced colorectal adenoma (OR = 3.382, 95% CI: 1.7006.342, P = 0.000). CONCLUSION:The study emphasizes the need for colon surveillance in patients with gastric dysplasia, regardless of H pylori infection.

show abstract

Section: Discussioncontrasting

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Gastric dysplasia may be an independent risk factor of anadvanced colorectal neoplasm

Bae¹,

Jeon²,

Cho³

et al. 2009

WJG

View full text Add to dashboard Cite

show abstract

“…A limited number of previous hospital-based case-control (22,23) and comparative studies (24)(25)(26)(27)(28) have reported an increased risk of colorectal neoplasia in the presence of H. pylori infection. As for CAG, two reports have described non-significant results for the correlation between colorectal cancer and CAG (29,30).…”

Section: Discussionmentioning

confidence: 99%

Elevated risk of recurrent colorectal neoplasia with Helicobacter pylori-associated chronic atrophic gastritis: A follow-up study of patients with endoscopically resected colorectal neoplasia

Inoue

Kato

Yoshimura

et al. 2012

Molecular and Clinical Oncology

View full text Add to dashboard Cite

Abstract.In a previous population-based case-control study, we demonstrated an elevated risk of colorectal neoplasia with Helicobacter pylori (H. pylori) infection. The present study investigated the effects of H. pylori-associated chronic gastritis on the development of colorectal neoplasia by analyzing the recurrence of colorectal neoplasia subsequent to endoscopic resection. Ninety-nine patients who had undergone endoscopic resection of colorectal neoplasia were monitored under colonoscopy, and the recurrence of colorectal neoplasia was prospectively investigated. The stage of H. pylori-associated chronic gastritis in each subject was evaluated using a combination of two serum tests: H. pylori antibody and pepsinogen. In the present cohort, colorectal neoplasia recurred at a rate of 15,296/100,000 person-years during the study period. After adjusting for the confounding factors, chronic atrophic gastritis (CAG) was identified as an independent risk factor [adjusted hazard ratio (HR), 2.72; 95% confidence interval, 1.33-5.57], while H. pylori-infected non-atrophic gastritis was not identified as an independent risk factor for recurrent colorectal neoplasia. Colorectal neoplasia recurred earlier and was significantly more frequent in patients with CAG (22,573/100,000 person-years) compared to patients without CAG (11,089/100,000 person-years; P=0.029, log-rank test).Patients with more extensive CAG showed a higher risk of recurrence. These results demonstrated a significant elevation of the risk of recurrent colorectal neoplasia with the establishment and progression of CAG, indicating the involvement of H. pylori infection in the development of colorectal neoplasia. The two serum tests were useful clinical markers for noninvasively evaluating the risk of each individual for recurrent colorectal neoplasia subsequent to endoscopic resection.

show abstract

“…The observation that chronic H. pylori infection promotes hypergastrinemia and that colon neoplasias also develop with an increase of gastrin serum led several authors to evaluate the possible association between the bacteria and the adenomas and adenocarcinomas of the colon. Epidemiological studies showed a greater prevalence of adenomas and/or adenocarcinomas in patients infected with H. pylori (2,5,10,11,23,24,30) . This association is, however, controversial because other researchers did not identify any association between adenomas and/or colon adenocarcinomas and infection caused by H. pylori (18,25,31,35) .…”

Section: Introductionmentioning

confidence: 99%

Seroprevalence of Helicobacter pylori in patients with colon adenomas in a brazilian university hospital

Buso

Rocha

Diogo

et al. 2009

Arq. Gastroenterol.

View full text Add to dashboard Cite

-Context -The association between Helicobacter pylori infection and colon neoplasia has been the subject of recent investigations which have produced controversial results. Objective -To evaluate the prevalence of H. pylori infection in patients with colonic adenomas and also in patients whose colonoscopy exams were normal. Methods -After colonoscopy, the individuals were distributed into two groups: patients with colon adenomas (cases) and patients whose colons were normal (controls). The groups were similar regarding age and gender. The individuals of both groups were subjected to a dosage of IgG antibody against H. pylori. The dosage was applied according to the solid phase, chemiluminescent immunometric assay. The chi-square test was used to analyze the data. Results -There were 30 men and 64 women in each group (94 cases and 94 controls). The mean age of the cases was 59.79 ± 12.25 years and that of the controls was 58.98 ± 11.55 years. The H. pylori serology was positive for 66 (70.21%) of the cases and for 51 (54.25%) of the controls. There was a significant difference (P = 0.024). The odds ratio was 1.98 (CI 95%, 0.82-3.15). The prevalence of H. pylori in cases and controls according to gender, histological type and location of the colon lesions showed a significant difference only among women (P = 0.03), among patients with tubular adenomas (P = 0.03), and in those with distal adenomas (P = 0.038). Conclusion -There is a positive association between H. pylori infection and colonic adenomas. This association is more evident in women, especially for tubular adenomas and distal colonic location. HEADINGS -Helicobacter pylori. Adenoma. Colonic neoplasms. Helicobacter infections.

show abstract

Helicobacter pylori infection is associated with colon adenomatous polyps detected by high‐resolution colonoscopy

Cited by 56 publications

References 17 publications

Gastric dysplasia may be an independent risk factor of anadvanced colorectal neoplasm

Gastric dysplasia may be an independent risk factor of anadvanced colorectal neoplasm

Elevated risk of recurrent colorectal neoplasia with Helicobacter pylori-associated chronic atrophic gastritis: A follow-up study of patients with endoscopically resected colorectal neoplasia

Seroprevalence of Helicobacter pylori in patients with colon adenomas in a brazilian university hospital

Contact Info

Product

Resources

About