Helicobacter pyloriinfection is associated with advanced colorectal neoplasia

Abstract

H. pylori infection is associated with the development of advanced colorectal neoplasia. More studies are needed to confirm our findings.

The association between Helicobacter pylori infection and the risk of advanced colorectal neoplasia may differ according to age and cigarette smoking

“…While the association between H. pylori infection and colorectal neoplasia has been suggested in some studies, others disagree . The reason for this discrepancy is currently uncertain, but our results suggest that age is an important factor that determines the association between H. pylori and ACN.…”

“…Unlike for CRA and CRC, the relationship between H. pylori infection and ACN has been reported in only a few studies. Shmuely et al reported on the relationship between H. pylori infection and ACN with odds ratios (OR) of 9.5 and 7.9 for ACN and CRC, respectively. However, the OR for CRC was unusually higher than that of previous meta‐analyses, and the number of cases in their study was relatively small (ACN, n = 77).…”

Influence of laboratory-related and endoscopy-related factors on the assessment of serum pepsinogens and gastrin-17

“…Several investigations have reported on a positive association between H. pylori infection and increased risk for the development of colonic neoplasms [19][20][21][22][23][24]. This has led to the proposal of combining colorectal cancer screening with PGI, PGII, and G-17 assessment.…”

Helicobacter pylori infection and increased diabetes prevalence were the risks of colorectal adenoma: a systematic review and meta-analysis

“…Serology was utilized as the detection method for H. pylori in 14 studies[8, 9, 21, 23, 25-27, 31-35, 38, 39], pathology in 4[3,22,40,42], UBT in 4[6,37], CLO in 6[19,24,30,36], and combining UBT and CLO in 2[28,29]. Gender and age are reported in 22[3,6,8,9,19,[21][22][23][24][25][26][27][28][29][30][34][35][36][37][38][39][40] and 27[3,6,8,9,19,[21][22][23][24][25][26][27][28][29][30][31]…”