Helicobacter pyloriinfection is not associated with nonalcoholic fatty liver disease

Abstract

H. pylori infection is not a risk factor for NAFLD as indicated by HSI or NAFLD-LFS. Prospective, large-scale studies involving liver biopsies should be considered.

Association between Helicobacter pylori infection and nonalcoholic fatty liver disease: A systematic review and meta‐analysis of observational studies

“…Of these potential eligible articles, we excluded 13 articles (characteristics of excluded articles see Table ) by examining the abstracts or full‐texts carefully for more detailed assessment. Finally, fifteen studies met the inclusion criteria and were included in our meta‐analysis. The detailed flowchart of selection process of eligible studies is shown in Figure .…”

“…These studies were published between 2013 and 2018, three of which were conference abstracts . Our meta‐analysis contained eleven cross‐sectional studies, two case‐control studies, one retrospective cohort study, and one prospective multicenter cohort . Eleven of these studies were from Asia, two studies from the United States, one from Greece, and one from Egypt .…”

“…Eleven of these studies were from Asia, two studies from the United States, one from Greece, and one from Egypt . With respect to the diagnosis of NAFLD, two studies used liver biopsy, one used imaging or histology, one used hepatic steatosis index, while remaining eleven studies used ultrasonography to detect NAFLD. As to H. pylori testing method, seven studies used UBT, four used serology to detect antibodies to H. pylori , one used RUT, one used SAT, and two used multiple methods .…”

“…The results of quality assessment according to NOS for observational studies are presented in Table . The scores of included studies ranged from four to nine (mean 7.5), only two studies scored six or less, and thirteen of which were high‐quality studies …”

Protective effect of quercetin on high-fat diet-induced non-alcoholic fatty liver disease in mice is mediated by modulating intestinal microbiota imbalance and related gut-liver axis activation

“…Moreover, we describe for the first time the association between high fat dietinduced NAFLD and enhanced Helicobacter genus detection. Even though is a controversial issue [45,46], it has been suggested the role of Helicobacter pilory as a contributing factor in the progression of NAFLD [47][48][49], considering its eradication as effective preventive or treatment measures [50,51]. Interestingly, Helicobacter genus was dramatically reduced by quercetin treatment in our model of NAFLD, corroborating its anti-Helicobacter activity observed in in vitro and in vivo models of infection [52,53], and supporting therapeutic potential of quercetin for prevention of the spectrum of non-alcoholic fatty liver diseases.…”