<i>Helicobacter Pylori</i> Infection is Positively Associated with Metabolic Syndrome in Taiwanese Adults: a Cross‐Sectional Study

Chen, Tsung-Po; Hung, Hui-Fang; Chen, Meng-Kan; Lai, Ho-Hsien; Hsu, Wen‐Feng; Huang, Kuo‐Chin; Yang, Kuen-Cheh

doi:10.1111/hel.12190

Cited by 72 publications

(87 citation statements)

References 45 publications

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“…Previous studies regarding the association of H. pylori infection with lipid metabolism showed relatively consistent evidence, but conflicting results also exist57182930. Especially, low socioeconomic level and crowded living conditions are important risk factors in H. pylori infection1516.…”

Section: Discussionmentioning

confidence: 99%

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Helicobacter pylori is associated with dyslipidemia but not with other risk factors of cardiovascular disease

Kim

Lee

Kang

et al. 2016

Sci Rep

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Epidemiologic and clinical data suggest that Helicobacter pylori infection is a contributing factor in the progression of atherosclerosis. However, the specific cardiovascular disease risk factors associated with H. pylori remain unclear. We performed a cross-sectional study of 37,263 consecutive healthy subjects who underwent a routine health check-up. In multivariable log Poisson regression models adjusted for potential confounders, the associations of H. pylori seropositivity with higher LDL-C (relative risk [RR], 1.21; 95% confidence interval [CI], 1.12–1.30) and lower HDL-C level (RR, 1.10; 95% CI, 1.01–1.18) were significant and independent. In multiple linear regression analyses, H. pylori infection was significantly associated with higher total cholesterol level (coefficient = 2.114, P < 0.001), higher LDL-C level (coefficient = 3.339, P < 0.001), lower HDL-C level (coefficient = −1.237, P < 0.001), and higher diastolic blood pressure (coefficient = 0.539, P = 0.001). In contrast, H. pylori infection was not associated with obesity-related parameters (body mass index, waist circumference), glucose tolerance (fasting glucose, glycated hemoglobin), and systolic blood pressure. We found that H. pylori infection was significantly and independently associated with dyslipidemia, but not with other cardiometabolic risk factors, after adjusting for potential risk factors of atherosclerosis.

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Section: Discussionmentioning

confidence: 99%

“…In addition, there are several studies regarding the role of H. pylori in risk factors of cardiovascular disease including type 2 diabetes, hypertension, dyslipidemia, obesity or metabolic syndrome57181920. However, only a few studies have investigated the relationships of H. pylori infection with each risk factor of cardiovascular disease.…”

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confidence: 99%

Helicobacter pylori is associated with dyslipidemia but not with other risk factors of cardiovascular disease

Kim

Lee

Kang

et al. 2016

Sci Rep

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“…Accumulated evidence has suggested that this infection is associated with metabolic diseases, such as metabolic syndrome (Chen et al, 2015a, Chen et al, 2015b), type 2 diabetes mellitus (T2DM) (He et al, 2014b) and atherosclerotic diseases (He et al, 2014a), yet the underlying mechanism is obscure. Insulin resistance (IR) and subsequent hyperinsulinemia are the key pathogenic factors contributing to these metabolic abnormalities.…”

Section: Introductionmentioning

confidence: 99%

Helicobacter pylori Infection Aggravates Diet-induced Insulin Resistance in Association With Gut Microbiota of Mice

Yang

Cheng

et al. 2016

EBioMedicine

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Emerging evidence suggests that Helicobacter pylori infection is associated with insulin resistance (IR) yet the underlying mechanisms are still obscure. The vital role of gut microbiota in triggering IR has been increasingly reported, however, no study has explored the correlation of gut microbiota and H. pylori-associated IR. Using H. pylori-infected mice model fed different diet structures, we demonstrated that H. pylori infection significantly aggravated high-fat diet (HFD)-induced metabolic disorders at the early stage, the extent of which was close to the effect of long-term HFD. Interestingly, we observed dynamic alterations in gut microbiota that were consistent with the changes in the metabolic phenotype induced by H. pylori and HFD. There may be an interaction among H. pylori, diet and gut microbiota, which dysregulates the host metabolic homeostasis, and treatment of H. pylori may be beneficial to the patients with impaired glucose tolerance in addition to diet control.

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“…Specifically, a cross-sectional study of a large population of Japanese adults evaluated the concentration of HP-specific immunoglobulin G (IgG) and found that HP-infected subjects had a significantly higher risk of MetS [10]. Another study reported a similar relationship [11], while others did not [12, 13]. These discrepancies may be related to the variation in HP-infection and gastritis status in the study populations.…”

Section: Introductionmentioning

confidence: 99%

Impact of Helicobacter pylori Immunoglobulin G Levels and Atrophic Gastritis Status on Risk of Metabolic Syndrome

et al. 2016

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BackgroundHelicobacter pylori (HP) infection is implicated in gastric and extra-gastric diseases. While gastritis-related chronic inflammation represents a known trigger of metabolic disturbances, whether metabolic syndrome (MetS) is affected by gastritis status remains unclear. We aimed to clarify the effect of HP-related gastritis on the risk of MetS.Materials and MethodsWe retrospectively enrolled patients undergoing screening for MetS between 2014 and 2015. Investigations included HP-specific immunoglobulin G (IgG) antibody assays to detect HP infection, and serum pepsinogen assays to evaluate atrophic gastritis status. The risk of MetS was evaluated via multiple logistic regression analyses with two covariates: serum HP infection status (IgG levels) and atrophic gastritis status (two criteria were applied; pepsinogen I/II ratio < 3 or both pepsinogen I levels ≤ 70 μg/L and pepsinogen I/II ratio < 3).ResultsOf 1,044 participants, 247 (23.7%) were HP seropositive, and 62 (6.0%) had MetS. HP seronegative and seropositive patients had similar risks of MetS. On the other hand, AG (defined in terms of serum PG I/II <3) was significant risk of MetS (OR of 2.52 [95% CI 1.05–7.52]). After stratification according to HP IgG concentration, patients with low HP infection status had the lowest MetS risk (defined as an odds ratio [OR] adjusted for age, sex, smoking, drinking and physical activity status). Taking this result as a reference, patients with negative, moderate, and high HP infection status had ORs (with 95% confidence intervals [CI]) of 2.15 (1.06–4.16), 3.69 (1.12–16.7), and 4.05 (1.05–26.8).ConclusionsHP-associated gastritis represents a risk factor for MetS. Research should determine why low and not negative HP infection status is associated with the lowest MetS risk.

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Helicobacter Pylori Infection is Positively Associated with Metabolic Syndrome in Taiwanese Adults: a Cross‐Sectional Study

Abstract: H. pylori infection is positively associated with metabolic syndrome, especially in females. The causal relationship between H. pylori infection and metabolic syndrome warrants further investigation.

Cited by 72 publications

References 45 publications

Helicobacter pylori is associated with dyslipidemia but not with other risk factors of cardiovascular disease

Helicobacter pylori is associated with dyslipidemia but not with other risk factors of cardiovascular disease

Helicobacter pylori Infection Aggravates Diet-induced Insulin Resistance in Association With Gut Microbiota of Mice

Impact of Helicobacter pylori Immunoglobulin G Levels and Atrophic Gastritis Status on Risk of Metabolic Syndrome

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