<i>hif-1</i>plays a role in hypoxia-induced gustatory plasticity of<i>Caenorhabditis elegans</i>

Sorathia, Nabila; Chawda, Neha; Saraki, Konstantina; Rajadhyaksha, Medha S.; Hejmadi, Momna

doi:10.1080/00207454.2019.1576662

Cited by 5 publications

(6 citation statements)

References 22 publications

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“…Misregulation of HIF-1 disrupts multiple facets of C. elegans ’ life, including hypoxia adaptation, hydrogen sulfide and hydrogen cyanide resistance, heat resistance, heavy metal toxicity tolerance, pathogen response, egg-laying defect, brood size and aging [22, 29, 30, 34–36, 38, 39, 44, 50, 61–64, 81, 82]. Our analyses provide a more complete understanding of gene expression changes that underpin these diverse phenotypes.…”

Section: Discussionmentioning

confidence: 99%

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Transcriptome analyses describe the consequences of persistent HIF-1 over-activation inCaenorhabditis elegans

Feng,

2023

Preprint

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Metazoan animals rely on oxygen for survival, but during normal development and homeostasis, animals are often challenged by hypoxia (low oxygen). In metazoans, many of the critical hypoxia responses are mediated by the evolutionarily conserved hypoxia-inducible transcription factors (HIFs). The stability and activity of HIF complexes are strictly regulated. In the model organismC. elegans, HIF-1 stability and activity are negatively regulated by VHL-1, EGL-9, RHY-1 and SWAN-1. Importantly,C. elegansmutants carrying strong loss-of-function mutations in these genes are viable, and this provides opportunities to interrogate the molecular consequences of persistent HIF-1 over-activation. We find that the genome-wide gene expression patterns are compellingly similar in these mutants, supporting models in which RHY-1, SWAN-1 and EGL-9 function in common pathway(s) to regulate HIF-1 activity. These studies illuminate the diversified biological roles played by HIF-1, including metabolism, hypoxia and other stress responses, reproduction and development. Genes regulated by persistent HIF-1 over-activation overlap with genes responsive to pathogens, and they overlap with genes regulated by DAF-16. As crucial stress regulators, HIF-1 and DAF-16 converge on key stress-responsive genes and function synergistically to enable hypoxia survival.

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Section: Discussionmentioning

confidence: 99%

“…HIF also contributes to the homeostasis of protein and iron [36, 42–47], reproduction, development and apoptosis [39, 48–50], and neural function and animal behaviors [41, 51–60]. Even more interestingly, HIF-1 has been shown to have roles in regulating animal lifespan [43, 44, 61–77].…”

Section: Introductionmentioning

confidence: 99%

Transcriptome analyses describe the consequences of persistent HIF-1 over-activation inCaenorhabditis elegans

Feng,

2023

Preprint

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“…Therefore, our results show for the first time, the high tolerance of desiccated P. superbus nematodes after full immersion in 99.99% Ga metal cage, with no negative effects on its survival and population growth. It suggests the operation of intrinsic strategies of anhydrobiotic repair machinery against a hypoxic/anoxic and metal-rich condition, such as hypoxia inducible factors (Sorathia et al, 2019) and, possibly, metalloproteins (Vijver et al, 2004;Li et al, 2016). Importantly, the cuticle also probably plays an important role in the protection against the metal.…”

Section: Discussionmentioning

confidence: 99%

Panagrolaimus superbus tolerates hypoxia within Gallium metal cage: implications for the understanding of the phenomenon of anhydrobiosis

Contiliani

Ribeiro

Moraes

et al. 2020

Journal of Nematology

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Panagrolaimus superbus nematodes are able to tolerate desiccation by entering into a peculiar state of suspended animation known as anhydrobiosis. When desiccated, anhydrobiotic organisms are also able to tolerate other physical stresses, as high and low levels of temperature and pressure. Here, we decided to investigate the tolerance of desiccated P. superbus to an unprecedented double stress-hypoxia within 99.99% Gallium (Ga) metal cage. The authors observed that regardless of the external relative humidity, desiccated P. superbus tolerated 7 d confined within the metal cage, displaying no negative effects on its survival and population growth rates over 40 d. The results evidence that anhydrobiosis also renders nematodes tolerant to otherwise lethal concentrations of Ga, in an oxygen-poor environment; thus, expanding its polyextremotolerance profile.

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“…In addition to regulating hypoxia response, it regulates responses to other stressors, including heat and toxic chemicals (heavy metal cadmium, ethidium bromide, selenium, nanopolystyrene, silver nanoparticles, tunicamycin, tert-butyl hydroperoxide, hydrogen sulfide and hydrogen cyanide), as well as pathogens (Staphylococcus aureus, Vibrio alginolyticus, enteropathogenic Escherichia coli, and Pseudomonas aeruginosa PA14 and PAO1) . HIF also contributes to the homeostasis of protein and iron [36,[42][43][44][45][46][47], reproduction, development and apoptosis [39,[48][49][50], and neural function and animal behaviors [41,[51][52][53][54][55][56][57][58][59][60]. Even more interestingly, HIF-1 has been shown to have roles in regulating animal lifespan [43,44,[61][62][63][64][65][66][67][68][69][70][71][72][73][74][75][76][77].…”

Section: Introductionmentioning

confidence: 99%

Transcriptome analyses describe the consequences of persistent HIF-1 over-activation in Caenorhabditis elegans

Feng,

Qu,

Powell-Coffman

2024

PLoS ONE

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Metazoan animals rely on oxygen for survival, but during normal development and homeostasis, animals are often challenged by hypoxia (low oxygen). In metazoans, many of the critical hypoxia responses are mediated by the evolutionarily conserved hypoxia-inducible transcription factors (HIFs). The stability and activity of HIF complexes are strictly regulated. In the model organism C. elegans, HIF-1 stability and activity are negatively regulated by VHL-1, EGL-9, RHY-1 and SWAN-1. Importantly, C. elegans mutants carrying strong loss-of-function mutations in these genes are viable, and this provides opportunities to interrogate the molecular consequences of persistent HIF-1 over-activation. We find that the genome-wide gene expression patterns are compellingly similar in these mutants, supporting models in which RHY-1, VHL-1 and EGL-9 function in common pathway(s) to regulate HIF-1 activity. These studies illuminate the diversified biological roles played by HIF-1, including metabolism and stress response. Genes regulated by persistent HIF-1 over-activation overlap with genes responsive to pathogens, and they overlap with genes regulated by DAF-16. As crucial stress regulators, HIF-1 and DAF-16 converge on key stress-responsive genes and function synergistically to enable hypoxia survival.

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hif-1plays a role in hypoxia-induced gustatory plasticity ofCaenorhabditis elegans

Cited by 5 publications

References 22 publications

Transcriptome analyses describe the consequences of persistent HIF-1 over-activation inCaenorhabditis elegans

Transcriptome analyses describe the consequences of persistent HIF-1 over-activation inCaenorhabditis elegans

Panagrolaimus superbus tolerates hypoxia within Gallium metal cage: implications for the understanding of the phenomenon of anhydrobiosis

Transcriptome analyses describe the consequences of persistent HIF-1 over-activation in Caenorhabditis elegans

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