HLA‐B*1511 is a risk factor for carbamazepine‐induced Stevens‐Johnson syndrome and toxic epidermal necrolysis in Japanese patients

Abstract

Summary Stevens‐Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but life‐threatening severe cutaneous adverse reactions. Recently, strong associations of HLA‐B*1502 with carbamazepine‐induced SJS/TEN have been found in Han Chinese patients. These associations have been confirmed in several Asian populations, excluding Japanese. SJS patients carrying HLA‐B*1508, HLA‐B*1511, or HLA‐B*1521, which are members of the HLA‐B75 type along with HLA‐B*1502, were detected in studies in India and Thailand. In the current study, we genotyped the HLA‐B locus from 14 Japanese typical and atypical SJS/TEN patients in whom carbamazepine was considered to be involved in the onset of adverse reactions. Although there were no HLA‐B*1502 carriers, four patients had HLA‐B*1511. Our data suggest that HLA‐B*1511, a member of HLA‐B75, is a risk factor for carbamazepine‐induced SJS/TEN in Japanese.

Pharmacogenetics of cutaneous adverse drug reactions

“…[20][21][22][23] Ueta et al reported a case-control study on the relationships between HLA class I and II genetic polymorphisms with severe ocular complications using 71 Japanese drug-unspecified SJS ⁄ TEN patients and 101 Japanese controls. No HLA-B*1502 carriers were detected in cases or controls.…”

Genetic and immune predictors for hypersensitivity syndrome to antiepileptic drugs

“…76 No association was found in Japanese, Korean or Caucasian individuals. HLA-A*3101 was recently associated with CBZ-HSR, CBZ-maculopapular exanthema and CBZ-SJS/TEN in North European Caucasians, 77 while HLA-B*1511 is associated with CBZ-SJS/TEN, 78 and HLA-A*3101 with CBZ-cutaneous ADRs in Japanese. 79 HLA-B*1502 was associated with CBZ-induced SJS/TEN, but not with CBZ-induced mild maculopapular eruptions in central China.…”

Association Between Carbamazepine Induced Severe Cutaneous Adverse Drug Reaction and Hla Polimorphisms

“…Pada dua penelitian berbeda di populasi Jepang HLA-A*31:01 (5 dari 6 pasien; 83,3%) dan HLA-B*15:11 (4 dari 14 pasien; 28,6%) menunjukkan hubungan dengan timbulnya SSJ-NET setelah mengkonsumsi karbamazepin. 19,20 Hal tersebut tidak berbeda jauh dengan hasil penelitian pada populasi Korea. Penderita SSJ-NET yang dipicu pemakaian karbamazepin pada populasi Korea diketahui memiliki HLA-A*31:01 dan HLA-B*15:11 dengan frekuensi yang sama (3 dari 7 pasien; 42,9%).…”