<i>HLA‐DQ</i> gene polymorphisms are associated with hepatocellular carcinoma and hepatitis B surface antigen in chronic hepatitis B virus infection

Ochi, Yuka; Hashimoto, Senju; Kawabe, Naoto; Murao, Michihito; Nakano, Takuji; Kan, Toshiki; Nakaoka, Kazunori; Ohki, Masashi; Kurashita, Takamitsu; Takamura, Tomoki; Nomura, Sayuri; Nishikawa, Toru; Fukui, Aiko; Osakabe, Keisuke; Ichino, Naohiro; Yoshioka, Kentaro

doi:10.1111/hepr.12812

Cited by 10 publications

(12 citation statements)

References 25 publications

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“…Several SNPs associated with HCC have been reported and expression profiles generated [ 62 , 63 ]. These polymorphisms alter biological pathways, including inflammation, oxidative stress, DNA repair, cell cycle and growth factors [ 64 , 65 ]. The association between aflatoxin B1 and CHB is well established, and a concomitant SNP of GTSM1 (glutathione- S -transferase mu1) and GSTT1 (glutathione- S -transferase theta1) is associated with a dramatic increase in HCC risk [ 66 ].…”

Section: Genetic Risk Factors In Hepatocellular Carcinoma Developmentmentioning

confidence: 99%

“…This indicates that the HCC risk attributable to specific polymorphisms depends on underlying risk factors and specific SNPs are associated with increased HCC risk in CHB. Such polymorphisms include SNPs of MDM2 (mouse double minute 2 homologue) and p53 [ 67 ]; XRCC3 (X-ray repair complementing defective repair in Chinese hamster cells 3) [ 68 ]; HLA (human leucocyte antigen)-DQ [ 64 ]; CTL-4 (cytotoxic T-lymphocyte antigen 4) [ 69 ]; GLB1 (galactosidase beta 1) [ 70 ] and TGF-β1 (transforming growth factor beta 1) but no other proinflammatory cytokines or interleukin-10 [ 71 ]. Nonetheless, these SNPs were mostly detected in collectives of CHB patients from the Far East or Asia and confirmatory studies in other patient populations are required.…”

Section: Genetic Risk Factors In Hepatocellular Carcinoma Developmentmentioning

confidence: 99%

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Viral hepatitis and liver cancer

Ringehan

McKeating

Protzer

2017

Phil. Trans. R. Soc. B

311

212

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Hepatitis B and C viruses are a global health problem causing acute and chronic infections that can lead to liver cirrhosis and hepatocellular carcinoma (HCC). These infections are the leading cause for HCC worldwide and are associated with significant mortality, accounting for more than 1.3 million deaths per year. Owing to its high incidence and resistance to treatment, liver cancer is the second leading cause of cancer-related death worldwide, with HCC representing approximately 90% of all primary liver cancer cases. The majority of viral-associated HCC cases develop in subjects with liver cirrhosis; however, hepatitis B virus infection can promote HCC development without prior end-stage liver disease. Thus, understanding the role of hepatitis B and C viral infections in HCC development is essential for the future design of treatments and therapies for this cancer. In this review, we summarize the current knowledge on hepatitis B and C virus hepatocarcinogenesis and highlight direct and indirect risk factors.This article is part of the themed issue ‘Human oncogenic viruses’.

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Section: Genetic Risk Factors In Hepatocellular Carcinoma Developmentmentioning

confidence: 99%

Section: Genetic Risk Factors In Hepatocellular Carcinoma Developmentmentioning

confidence: 99%

Viral hepatitis and liver cancer

Ringehan

McKeating

Protzer

2017

Phil. Trans. R. Soc. B

311

212

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“…Chronic HBV infection remains a serious global health problem [26,27]. It was reported that host genetic factors played an important role in the pathogenesis of HBV infection, and the polymorphisms of cytokine genes were strongly associated with the susceptibility to HBV infection in the general population [28,29]. ere is enough evidence that genetic variants of IFN-c signaling pathway genes play important roles in the HBV infection in adults [30][31][32].…”

Section: Discussionmentioning

confidence: 99%

Single Nucleotide Polymorphisms in IFN-γSignaling Pathway Associated with Risk of Hepatitis B Virus Infection in Chinese Children

Yang

Zhang

et al. 2020

Canadian Journal of Infectious Diseases and Medical Microbiolog

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Hepatitis B virus (HBV) infection is a challenging public health problem in China and worldwide. Mother-to-child transmission is one of the main transmission routes of HBV in highly endemic regions. However, the mechanisms of HBV perinatal transmission in children have not been clearly defined. The aim of this study was to demonstrate the association between single-nucleotide polymorphisms (SNPs) in IFN-γ signaling pathway and HBV infection or breakthrough infection in children. Two hundred and seventy-four HBV-infected children defined as test positive for hepatitis B surface antigen (HBsAg) and 353 controls defined as negative for HBsAg in China were recruited from October 2013 to May 2015. SNPs in IFN-γ signaling pathway including IFNG, IFNGR1, IFNGR2, and IL12B were genotyped. Rs2234711 in IFNGR1 was significantly associated with HBV infection in children (OR = 0.641, 95% CI: 0.450–0.913). In addition, rs2234711 was also significantly associated with HBV breakthrough infection in children born to HBsAg-positive mothers (OR = 0.452, 95% CI: 0.205–0.998). Our study confirmed that genetic variants in IFN-γ signaling pathway have significant associations with HBV infection, especially with HBV breakthrough in children. This study provides insight into HBV infection in children and could be used to help design effective strategies for reducing immunoprophylaxis failure.

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“…15 Additionally, some single-nucleotide polymorphisms in several genes including HLA class I and II have been shown to be associated with HBV-related HCC. [16][17][18] It has been reported that NAs reduced HCC risk, but the effect is not adequate, especially in patients with advanced liver fibrosis. 6,[19][20][21] The HBV genomic sequences are heterogeneous, and based on differences of >8%, 22 10 genotypes (A to J) have been reported so far.…”

Section: H Epatitis B Virus (Hbv) Infection Is a Worldwidementioning

confidence: 99%

“…Recently, the hepatitis B X protein genotype was reported to be associated with HCC development and HCC proliferation in vitro and in vivo . Additionally, some single‐nucleotide polymorphisms in several genes including HLA class I and II have been shown to be associated with HBV‐related HCC . It has been reported that NAs reduced HCC risk, but the effect is not adequate, especially in patients with advanced liver fibrosis …”

Section: Introductionmentioning

confidence: 99%

Comparison of hepatitis B virus genotypes B and C among chronically hepatitis B virus‐infected patients who received nucleos(t)ide analogs: A multicenter retrospective study

Inoue

Akahane²,

Nakayama³

et al. 2019

Hepatology Research

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Aim Hepatitis B virus genotype B (HBV/B) has been reported to have less risk of liver cirrhosis and hepatocellular carcinoma (HCC), but long‐term observation has rarely been reported. We aimed to clarify the characteristics of HBV/B in nucleos(t)ide analog‐treated patients in an area where HBV/B is more prevalent than in other areas of Japan. Methods A total of 498 chronically HBV‐infected patients treated with nucleos(t)ide analog (lamivudine, entecavir, tenofovir disoproxil fumarate, or tenofovir alafenamide fumarate) for >6 months (mean 70.6 months) were included from nine hospitals in northeast Japan. The frequencies of hepatitis B surface antigen loss and HCC occurrence were analyzed. Results Among 427 patients whose genotype could be determined, 34.0% and 64.4% were infected with HBV/B and genotype C (HBV/C), respectively. The age of patients with HBV/B was significantly older than those with HBV/C (57.7 vs. 48.1). The cumulative rate of hepatitis B surface antigen loss was significantly higher in HBV/B than in HBV/C (3.6% vs. 0.7% at 10 years). Among 480 patients without HCC history, HCC occurrence was found in 40 patients (13.4% at 10 years). There was no cumulative rate difference of HCC occurrence among the genotypes, but after propensity score matching for age/sex, it was significantly lower in HBV/B than in HBV/C (5.3% vs. 18.5% at 10 years). Conclusions Although a lower rate of HCC occurrence in HBV/B was shown by an age/sex‐matched analysis than that in HBV/C, patients with HBV/B were significantly older and had a comparative risk of HCC occurrence in nucleos(t)ide analog‐treated patients.

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HLA‐DQ gene polymorphisms are associated with hepatocellular carcinoma and hepatitis B surface antigen in chronic hepatitis B virus infection

Abstract: This study revealed an association between rs2856718 and HCC development and an association between rs7453920 and HBsAg levels.

Cited by 10 publications

References 25 publications

Viral hepatitis and liver cancer

Viral hepatitis and liver cancer

Single Nucleotide Polymorphisms in IFN-γSignaling Pathway Associated with Risk of Hepatitis B Virus Infection in Chinese Children

Comparison of hepatitis B virus genotypes B and C among chronically hepatitis B virus‐infected patients who received nucleos(t)ide analogs: A multicenter retrospective study

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