<i>HLA‐DQB1*04:02:13</i>, an <i>HLA‐DQB1*04:02</i> variant, identified in a Kuwaiti individual

Jahromi, Mohamed; Al-Khuwari, Mona; Lin, P. Y.; Yang, K. L.

doi:10.1111/tan.13714

Cited by 3 publications

(2 citation statements)

References 5 publications

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“…HLA genes are not transmitted randomly from parent to offspring, with solid linkage disequilibrium between A, C, B, DR and DQ alleles, i.e., haplotypes (2,34,37,(41)(42)(43)47,49,51,56,58,(62)(63)(64)(65)(66)(67)(68)(69)(70). However, T1D susceptibility haplotypes exist in a limited number.…”

Section: Genetic Susceptibility: Hla In Arab Populationmentioning

confidence: 99%

“…In order to confirm previously reported HLA data in Arab population we have recently accomplished our 11 loci HLA typing using the state of art technology of Next Genome Sequencing (NGS). We have come to extraordinary findings which have been published/or are in process (25,(41)(42)(43). We have come across unique Arab specific haplotypes, novel association of DRBs and DQBs in T1D.…”

Section: Introductionmentioning

confidence: 99%

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Recent Expeditious Growth of Type 1 Diabetes in the Gulf Arab Countries

Jahromi¹,

Sheikh²,

Tuomilehto³

2021

Preprint

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The incidence of Type 1 Diabetes (T1D) in the Arab world, particularly, oil and gas rich Gulf Cooperative Council (GCC) countries has more than doubled in the last twenty years. Therefore, there is a dire need for careful systematic familial cohort studies, especially in high-risk populations. Several immunogenetic factors affect the pathogenesis of the disease. Genes in the human leukocyte antigen (HLA) account for the major genetic susceptibility to the disease. The triggering agents initiate disease onset by destruction of pancreatic β-cells. The autoantibodies against glutamic acid decarboxylase (GADA), insulinoma antigen-2 (IA-2A), insulin (IAA), and zinc transporter-8 (ZnT-8A) comprise the most reliable biomarkers for T1D in both children and adults. Although three of the GCC countries, namely Kuwait, Saudi Arabia and Qatar are among the top 10 countries with high incidence rate of T1D, no proper diagnostic and prediction tools were applied in the region. Understanding the disease sequelae in a homogenous gene pool with high consanguinity in the GCC could help solve the challenges in understanding pathogenesis, as well as hasten the prevention of T1D. Arab states must incorporate T1D predictive and intervention policies on a war-footing basis to minimize the burden of this serious disease.

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Section: Genetic Susceptibility: Hla In Arab Populationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Recent Expeditious Growth of Type 1 Diabetes in the Gulf Arab Countries

Jahromi¹,

Sheikh²,

Tuomilehto³

2021

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

Nomenclature for factors of the HLA system, update January, February and March 2020

Marsh

2020

Int J Immunogenetics

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Nomenclature for factors of the HLA system, update January, February and March 2020

Marsh

2020

HLA

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HLA‐DQB104:02:13, an HLA‐DQB104:02 variant, identified in a Kuwaiti individual

Abstract: One nucleotide substitution in codon 213 of HLA‐DQB104:02:01:01 results in a new allele, HLA‐DQB104:02:13.

Cited by 3 publications

References 5 publications

Recent Expeditious Growth of Type 1 Diabetes in the Gulf Arab Countries

Recent Expeditious Growth of Type 1 Diabetes in the Gulf Arab Countries

Nomenclature for factors of the HLA system, update January, February and March 2020

Nomenclature for factors of the HLA system, update January, February and March 2020

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HLA‐DQB1*04:02:13, an HLA‐DQB1*04:02 variant, identified in a Kuwaiti individual

Abstract: One nucleotide substitution in codon 213 of HLA‐DQB1*04:02:01:01 results in a new allele, HLA‐DQB1*04:02:13.

Cited by 3 publications

References 5 publications

Recent Expeditious Growth of Type 1 Diabetes in the Gulf Arab Countries

Recent Expeditious Growth of Type 1 Diabetes in the Gulf Arab Countries

Nomenclature for factors of the HLA system, update January, February and March 2020

Nomenclature for factors of the HLA system, update January, February and March 2020

Contact Info

Product

Resources

About

HLA‐DQB104:02:13, an HLA‐DQB104:02 variant, identified in a Kuwaiti individual

Abstract: One nucleotide substitution in codon 213 of HLA‐DQB104:02:01:01 results in a new allele, HLA‐DQB104:02:13.