HLA-DRB1*1501 intensifies the impact of IL-6 promoter polymorphism on the susceptibility to multiple sclerosis in an Iranian population

Abstract

We suggest more studies to confirm these results in other populations.

Interleukin-6 Gene Promoter-572 C Allele May Play a Role in Rate of Disease Progression in Multiple Sclerosis

“…Interestingly, the decrease was not seen in patients with PP-MS. Our results are in striking contrast to those of both Shahbazi et al , who found an increased risk for MS associated with the G allele of −174 in an Iranian cohort [11], and of Mirowska-Guzel et al , who found increased risk of MS to be associated with the C allele of −174, particularly with the CC genotype in a Polish cohort [10]. Whether these differences are due to differences in the ethnicity of the populations, or to some other factor, remains to be determined.…”

“…[10] 228 MS and 193 controls; Shahbazi et al . [11] 345 MS and 426 controls; Mihailova et al . [9] 55 MS and 86 controls; Fedetz et al .…”

“…Several studies have investigated whether two promoter region polymorphisms in the gene encoding interleukin 6 (IL-6), a pleiotropic cytokine that is an important mediator of many inflammatory processes, including induction of the acute phase response and differentiation of lymphocytes and monocytes, might enhance susceptibility to MS [8–11]. Increased levels of IL-6 have been detected in mononuclear cells in the blood and cerebrospinal fluid (CSF) [12–14] and in brain tissue of patients with MS [15].…”

“…The −174 C allele can suppress IL-6 transcription [18], but less is known of the functional correlates of other IL6 promoter polymorphisms. In the MS studies, two groups reported no linkage between the −597 and −174 IL6 promoter polymorphisms and MS [8,9], whereas the other 2 studies did report significant correlations, but with different alleles/genotypes [10,11]. In all of these studies, the numbers of patients were fairly low, and few PP-MS patients were tested.…”

Human leukocyte antigen variation among Iranian renal transplant recipients

“…HLA is the most informative genetic system known to date (1).Several researchers have focused on HLA as a potential risk allele in the pathogenesis of some diseases (2)(3)(4). On the other hand, HLA polymorphism is kind of epidemiological risk factor for some diseases.…”