Helicobacter pylori
 
 infection does not promote hepatocellular cancer in a transgenic mouse model of hepatitis C virus pathogenesis

García, Alexis; Feng, Yan; Parry, N.; McCabe, Amanda; Mobley, Melissa W.; Lertpiriyapong, Kvin; Whary, Mark T.; Fox, James G.

doi:10.4161/gmic.26042

Cited by 15 publications

(17 citation statements)

References 76 publications

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“…Nevertheless, García et al. reported a negative association between H. pylori and HCC in a transgenic mouse model of HCV, leaving this topic open to further evaluation.…”

Section: Hepatobiliary Diseasesmentioning

confidence: 99%

“…Concerning this issue, Wang et al [58] reported a significant association between H. pylori infection and an increased risk of death from liver cancer among rural Chinese residents. Nevertheless, Garc ıa et al [59] reported a negative association between H. pylori and HCC in a transgenic mouse model of HCV, leaving this topic open to further evaluation. Some studies also investigated the possible role of H. pylori in biliary tract diseases.…”

Section: Hepatobiliary Diseasesmentioning

confidence: 99%

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Helicobacter pylori and Extragastric Diseases

Franceschi¹,

Tortora

Gasbarrini³

et al. 2014

Helicobacter

127

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While Helicobacter pylori infection was initially revealed to be associated only with some gastroduodenal diseases, further studies have shown its possible role in several extragastric diseases. For idiopathic thrombocytopenic purpura, sideropenic anemia, and vitamin B12 deficiency, the diagnosis of H. pylori infection is recommended, and there are many other conditions such as cardiovascular, neurological, dermatological, and respiratory diseases in which H. pylori may possibly play a role. Interestingly, a potential role has also been described for GI neoplastic diseases, including colorectal and pancreatic cancer. Different mechanisms of action have been proposed, ranging from the induction of a low grade inflammatory state to the occurrence of molecular mimicry mechanisms. This review summarizes the results of the most relevant studies published on this topic over the last year.

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“…Nevertheless, García et al. reported a negative association between H. pylori and HCC in a transgenic mouse model of HCV, leaving this topic open to further evaluation.…”

Section: Hepatobiliary Diseasesmentioning

confidence: 99%

Section: Hepatobiliary Diseasesmentioning

confidence: 99%

Helicobacter pylori and Extragastric Diseases

Franceschi¹,

Tortora

Gasbarrini³

et al. 2014

Helicobacter

127

View full text Add to dashboard Cite

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“…In contrast, H. pylori infection is associated with an increased risk of colorectal cancer [9,[32][33][34]. Finally, evidence to support an association with other nongastric GI cancers is sparse, and null associations have been reported [8,[35][36][37][38][39][40]. In addition to H. pylori, several other environmental factors are associated with the risk of both PUD and cancer.…”

Section: Discussionmentioning

confidence: 99%

Long‐term risk of gastrointestinal cancers in persons with gastric or duodenal ulcers

et al. 2016

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Peptic ulcer predicts gastric cancer. It is controversial if peptic ulcers predict other gastrointestinal cancers, potentially related to Helicobacter pylori or shared lifestyle factors. We hypothesized that gastric and duodenal ulcers may have different impact on the risk of gastrointestinal cancers. In a nationwide cohort study using Danish medical databases 1994–2013, we quantified the risk of gastric and other gastrointestinal cancers among patients with duodenal ulcers (dominantly H. pylori‐related) and gastric ulcers (dominantly lifestyle‐related) compared with the general population. We started follow‐up 1‐year after ulcer diagnosis to avoid detection bias and calculated absolute risks of cancer and standardized incidence ratios (SIRs). We identified 54,565 patients with gastric ulcers and 38,576 patients with duodenal ulcers. Patient characteristics were similar in the two cohorts. The 1–5‐year risk of any gastrointestinal cancer was slightly higher for gastric ulcers patients (2.1%) than for duodenal ulcers patients (2.0%), and SIRs were 1.38 (95% CI: 1.31–1.44) and 1.30 (95% CI: 1.23–1.37), respectively. The SIR of gastric cancer was higher among patients with gastric ulcer than duodenal ulcer (1.92 vs. 1.38), while the SIRs for other gastrointestinal cancers were similar (1.33 vs. 1.29). Compared with gastric ulcer patients, duodenal ulcer patients were at lower risk of smoking‐ and alcohol‐related gastrointestinal cancers. The risk of nongastric gastrointestinal cancers is increased both for patients with gastric ulcers and with duodenal ulcers, but absolute risks are low. H. pylori may be less important for the development of nongastric gastrointestinal cancer than hypothesized.

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“…Suggestions that the etiology or the severity of the liver disease could be related to Helicobacter pylori infection were not confirmed (Calvet et al, 1997). H. pylori is a gastric pathogen that does not promote hepatocellular cancer and suggest that the HCV transgene is associated with amelioration of specific liver and gastric lesions observed during concurrent H. pylori infection in mice (García et al, 2013). The present study suggest that a large happening of H. pylori infection in the liver is specified in patients with hepatocellular carcinoma than in chronic liver diseases patients, propose a prospective correlation between H. pylori infection and liver cancer so H. pylori infection associate with the development of hepatocellular carcinoma.…”

Section: Discussionmentioning

confidence: 99%

The Relation between Helicobacter Pylori Infection and Hepatocellular Carcinoma in Egyptian Patients

Serag¹

2015

American Journal of Biochemistry and Biotechnology

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This work to show the relation between Helicobacter Pylori infection and Hepatocellular Carcinoma in Egyptian patients. This study was completed at National liver institute in Egypt. Patients in this study were recognized cases of chronic Hepatitis C virus liver disease with and without hepatocellular carcinoma. Serum samples of patients of hepatocellular carcinoma with hepatitis C Virus (HCV) of 40 male and 30 female adults had been collected, Helicobacter pylori (H. pylori) was detected by enzyme linked immunosorbent assay with comparison with ten males and ten females patients as control groups with chronic Hepatitis C Virus (HCV) without HCC. All patients were free from hepatitis B virus (HBV) infection, without cigarette smoking and without alcohol drinking. Positive H. pylori was found more in male and female patients with hepatocellular carcinoma combined by chronic HCV than those with HCV without hepatocellular carcinoma and there was significant difference between both groups. There is a significant association between infection with H. pylori, elevated titers of H. pylori antibodies and the increased risk of hepatocellular carcinoma in males and females Egyptian patients.

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Helicobacter pylori infection does not promote hepatocellular cancer in a transgenic mouse model of hepatitis C virus pathogenesis

Cited by 15 publications

References 76 publications

Helicobacter pylori and Extragastric Diseases

Helicobacter pylori and Extragastric Diseases

Long‐term risk of gastrointestinal cancers in persons with gastric or duodenal ulcers

The Relation between <i>Helicobacter Pylori</i> Infection and Hepatocellular Carcinoma in Egyptian Patients

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