1988
DOI: 10.1080/02772248809357270
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In Situdetection of DNA adducts formed in cultured cells by Benzo(a)pyrene diolepoxide (BPDE), with monoclonal antibodies specific for the BP‐Deoxyguanosine Adduct

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1988
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Cited by 14 publications
(11 citation statements)
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“…Animal Immunogen Isotype Cross-reactivity mAb 8E11 [35,36] Balb/cCr mice BPDE-I-G-BSA IgG1, Kappa No mAb E5 [36,40] Balb/cCr mice BPDE-I-G-BSA unknown No mAb 5D11 [35,36] Balb/cCr mice BPDE-I-DNA-MBSA IgG2, Kappa Yes mAb 41D3 [39] Balb/cCr mice BPDE-I-DNA-MBSA unknown Yes mAb 5D2 [37,38] Balb/cCr mice BPDE-I-DNA-MBSA IgG1, Kappa Unknown mAb 1D7 [37] Balb/cCr mice BPDE-I-DNA-MBSA IgG1, Kappa Unknown mAb 4C2 [37] Balb/cCr mice BPDE-I-DNA-MBSA IgG1, Kappa Unknown mAb TNO [39] Balb/cCr mice BPDE-I-DNA-MBSA Unknown Unknown pAb #29 [37] New Zealand white rabbits BPDE-I-modified DNA Unknown Yes pAb BP1 [38] New Zealand white rabbits BPDE-I-modified DNA Unknown Yes pAb F29, F30, NCI [39] New Zealand white rabbits BPDE-I-DNA-MBSA Unknown Yes mAb and pAb refer to monoclonal antibody and polyclonal antibody, respectively.…”
Section: Antibodymentioning
confidence: 99%
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“…Animal Immunogen Isotype Cross-reactivity mAb 8E11 [35,36] Balb/cCr mice BPDE-I-G-BSA IgG1, Kappa No mAb E5 [36,40] Balb/cCr mice BPDE-I-G-BSA unknown No mAb 5D11 [35,36] Balb/cCr mice BPDE-I-DNA-MBSA IgG2, Kappa Yes mAb 41D3 [39] Balb/cCr mice BPDE-I-DNA-MBSA unknown Yes mAb 5D2 [37,38] Balb/cCr mice BPDE-I-DNA-MBSA IgG1, Kappa Unknown mAb 1D7 [37] Balb/cCr mice BPDE-I-DNA-MBSA IgG1, Kappa Unknown mAb 4C2 [37] Balb/cCr mice BPDE-I-DNA-MBSA IgG1, Kappa Unknown mAb TNO [39] Balb/cCr mice BPDE-I-DNA-MBSA Unknown Unknown pAb #29 [37] New Zealand white rabbits BPDE-I-modified DNA Unknown Yes pAb BP1 [38] New Zealand white rabbits BPDE-I-modified DNA Unknown Yes pAb F29, F30, NCI [39] New Zealand white rabbits BPDE-I-DNA-MBSA Unknown Yes mAb and pAb refer to monoclonal antibody and polyclonal antibody, respectively.…”
Section: Antibodymentioning
confidence: 99%
“…The stereochemistry of the four anti-BPDE-N 2 -dG adducts has been proved to determine their respective mutagenesis and carcinogensis [29][30][31][32][33][34]. A number of antisera have been produced for developing sensitive and specific immunoassay of BPDE-DNA adducts (Table 1) [35][36][37][38][39][40]. These antibodies exhibit varied affinity, stereoselectivity, and specificity.…”
Section: Introductionmentioning
confidence: 99%
“…However, the use of antibodies against DNA adducts offers the possibility of studying DNA ad- duct formation at the level of the single cell. Several groups (13,14,16,17) reported the use of antibodies in in situ detection of benzo(a)pyrene (BP) DNA adducts. At our institute, a mouse monoclonal antibody (MAb), KE4, has been developed that recognizes BP DNA adducts (14).…”
Section: Introductionmentioning
confidence: 99%
“…At our institute, a mouse monoclonal antibody (MAb), KE4, has been developed that recognizes BP DNA adducts (14). It was applied both in in vitro studies, in which human fibroblasts (14) or white blood cells (WBCs) (16) were treated with the diolepoxide of BP, and in vivo studies (15), in which bronchial cells were obtained from smoking individuals.…”
Section: Introductionmentioning
confidence: 99%
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