In situ generation of H2O2 using CaO2 as peroxide storage depot for haloperoxidase mimicry with surface-tailored Bi-doped mesoporous CeO2 nanozymes

Pütz, Eva; Tutzschky, Ina; Frerichs, Hajo; Tremel, Wolfgang

doi:10.1039/d2nr02575b

Cited by 7 publications

(3 citation statements)

References 58 publications

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“…For further testing a 10 mg/mL reaction solution of cerium dioxide NCs in ultrapure water was used. Detailed characterizations of the NCs are summarized in the Supporting Information and further information about the synthesis was described by Puẗz et al 18 2.2. Degradation Batch Experiments.…”

Section: Chemicals Analytical Methods and Nc Synthesismentioning

confidence: 99%

Bromination of Quorum Sensing Molecules: Vanadium Bromoperoxidase and Cerium Dioxide Nanocrystals via Free Active Bromine Transform Bacterial Communication

Keltsch

Pütz

Dietrich

et al. 2023

Environ. Sci. Technol.

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The halogenation of quorum sensing molecules (QSMs) is known to be catalyzed by enzymes such as haloperoxidase (HPO) as well as cerium dioxide nanocrystals (NC), which mimic enzymes. Those enzymes and mimics can influence biological processes such as biofilm formation, where bacteria use QSMs for the "chemical" communication between each other and the coordination of surface colonization. However, not much is known about the degradation behavior of a broad spectrum of QSMs, especially for HPO and its mimics. Therefore, in this study, the degradation of three QSMs with different molecule moieties was elucidated. For this purpose, different batch experiments were carried out with HPOs, NCs and free active bromine (FAB). For N-βketocaproyl-homoserine lactone (3-Oxo-C 6 -AHL), N-cis-tetradec-9Zenoyl-homoserine lactone (C 14:1 -AHL) and 2-heptyl-4-quinolone (HHQ) a fast degradation and moiety-specific transformations were observed. The HPO vanadium bromoperoxidase as well as cerium dioxide NCs catalyzed the formation of the same brominated transformation products (TPs). Since the same TPs are formed in batch experiments with FAB it is very likely that FAB is playing a major role in the catalytical reaction mechanism leading to the transformation of QSMs. In this study in total 17 TPs could be identified in different levels of confidence and the catalytic degradation processes for two QS groups (unsaturated AHLs and alkyl quinolones) with cerium dioxide NCs and vanadium bromoperoxidase were expanded.

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Section: Chemicals Analytical Methods and Nc Synthesismentioning

confidence: 99%

Bromination of Quorum Sensing Molecules: Vanadium Bromoperoxidase and Cerium Dioxide Nanocrystals via Free Active Bromine Transform Bacterial Communication

Keltsch

Pütz

Dietrich

et al. 2023

Environ. Sci. Technol.

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“…12,13 HOBr can induce serious damage and disrupt chemical signaling among fouling organisms, effectively preventing biofilm formation and subsequent biofouling. Up to now, researchers have extensively discovered that inorganic HPO mimics such as vanadium pentoxide, 12 ceria, 14 and nickel−molybdenum bimetallic sulfide. 15 CeO 2 has high chemical stability and is environmentally friendly due to its insolubility.…”

Section: ■ Introductionmentioning

confidence: 99%

“…Biofouling, the undesirable accumulation of organisms on submerged surfaces, hindered the development of marine engineering and led to significant economic losses. , Haloperoxidase (HPO) can catalyze hydrogen peroxide (H 2 O 2 ) and halides (Cl – and Br – ) to form hypohalous acids (HOCl and HOBr). , HOBr can induce serious damage and disrupt chemical signaling among fouling organisms, effectively preventing biofilm formation and subsequent biofouling. Up to now, researchers have extensively discovered that inorganic HPO mimics such as vanadium pentoxide, ceria, and nickel–molybdenum bimetallic sulfide . CeO 2 has high chemical stability and is environmentally friendly due to its insolubility .…”

Section: Introductionmentioning

confidence: 99%

Chemically Modulating Ceria-Based Artificial Haloperoxidase for Enhanced Antibacterial Activity and Biofilm Inhibition

He,

Su,

Bai

et al. 2024

ACS Appl. Mater. Interfaces

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Ceria (CeO2) nanoparticles with haloperoxidase (HPO)-like activity have gained attention as a biologically benign antifoulant. 3,4-Dihydroxy-l-phenylalanine (DOPA), a main composition in mussel foot proteins, plays a crucial role in the biofouling process. However, the impact on the HPO-like activity and antifouling performance of CeO2 nanoparticles when DOPA molecules adsorb on them remains unexplored. This interesting question warrants investigation, particularly considering that it may occur in an actual marine environment. Herein, the interaction between DOPA and CeO2 is explored. Despite the higher Ce3+ fractions and the lower band gap energies due to the electron transfer from DOPA to the CeO2 surface, DOPA still had a slightly negative effect on the HPO-like activity of CeO2 since they decreased the exposed Ce3+ sites. The DOPA-CeO2 nanocomposites with HPO-like activities could kill bacteria and trigger quorum-sensing signaling quenching, achieving a biofilm inhibition performance. Amazingly, 0.1% DOPA-CeO2 nanocomposite exhibited higher antibacterial activity and better biofilm suppression activities due to its HPO-like activity and positive zeta potential. The remarkable results demonstrated that DOPA, as a participant in the biofouling process, could enhance the antibacterial activity and antifouling performance of CeO2 nanoparticles at an appropriate concentration.

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Waste to worth: Facile preparation of CaO2 derived from oyster shells for highly efficient degradation of organic contaminants based on Fenton-like system

Chen,

Ju,

et al. 2024

Inorganic Chemistry Communications

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In situ generation of H₂O₂ using CaO₂ as peroxide storage depot for haloperoxidase mimicry with surface-tailored Bi-doped mesoporous CeO₂ nanozymes

Abstract: Designing the size, morphology and interfacial charge of catalyst particles at the nanometer scale can enhance their performance. We demonstrate this with nanoceria which is a functional mimic of haloperoxidases,...

Cited by 7 publications

References 58 publications

Bromination of Quorum Sensing Molecules: Vanadium Bromoperoxidase and Cerium Dioxide Nanocrystals via Free Active Bromine Transform Bacterial Communication

Bromination of Quorum Sensing Molecules: Vanadium Bromoperoxidase and Cerium Dioxide Nanocrystals via Free Active Bromine Transform Bacterial Communication

Chemically Modulating Ceria-Based Artificial Haloperoxidase for Enhanced Antibacterial Activity and Biofilm Inhibition

Waste to worth: Facile preparation of CaO2 derived from oyster shells for highly efficient degradation of organic contaminants based on Fenton-like system

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