<i>In situ</i> preparation of gold–polyester nanoparticles for biomedical imaging

Attia, Mohamed F.; Ranasinghe, Meenakshi; Akasov, Roman; Anker, Jeffrey N.; Whitehead, Daniel C.; Alexis, Frank

doi:10.1039/d0bm00175a

Cited by 6 publications

(3 citation statements)

References 46 publications

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“…PMO1 (control), PMO2, and PMO3 were synthesized using DMF as described above, while PMO4 was prepared using toluene in place of DMF to produce particles with different morphologies. Poly(ethylene glycol)- co -poly( d , l -lactic acid) (PEG–PDLLA) polymer was synthesized following a standard ring-opening polymerization method as previously reported. , PEG–PDLLA was incorporated with starting materials in different concentrations with regard to BTEB for yielding PMO2 (BTEB/PEG–PDLLA = 85:15) and PMO3 (BTEB/PEG–PDLLA = 75:25).…”

Section: Methodsmentioning

confidence: 99%

“…Poly(ethylene glycol)-co-poly(D,L-lactic acid) (PEG−PDLLA) polymer was synthesized following a standard ringopening polymerization method as previously reported. 31,32 PEG− PDLLA was incorporated with starting materials in different concentrations with regard to BTEB for yielding PMO2 (BTEB/ PEG−PDLLA = 85:15) and PMO3 (BTEB/PEG−PDLLA = 75:25).…”

Section: Methodsmentioning

confidence: 99%

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Polymer-Scaffolded Synthesis of Periodic Mesoporous Organosilica Nanomaterials for Delivery Systems in Cancer Cells

Attia

Akasov

Alexis

et al. 2020

ACS Biomater. Sci. Eng.

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We developed four types of para-phenylene-bridged periodic mesoporous organosilica NPs (p-P PMO NPs) with tailored physical parameters including size, morphology, porosity, and surface area using a new polymer-scaffolding approach. The particles have been formulated to facilitate the codelivery of small-molecule hydrophobic/hydrophilic cargos such as model anticancer drugs (i.e., doxorubicin hydrochloride (DOX) and O 6-benzylguanine) and model fluorescent dyes (i.e., rhodamine 6G and Nile red). p-P PMO NPs were synthesized via a cetyltrimethylammonium bromide (CTAB)-directed sol–gel process using two different organic solvents and in the presence of polymeric scaffolding constituents that led to morphologically distinct PMO NPs despite using the same organosilane precursors. After the formulation process, the polymeric scaffolding agent was conveniently washed away from the PMO NPs. Extensive analyses were used to characterize the physicochemical attributes of the PMO NPs such as their chemical composition, morphologies, etc. Spherical and rod-shaped PMOs of diameters ranging between 79 and 342 nm, surface areas between 770 and 1060 m2/g, and pore volumes between 0.79 and 1.37 cm3/g were prepared using the polymer-scaffolding approach. The performance of these materials toward drug-loading capacity, cytotoxicity, and cancer cell internalization was evaluated. Interestingly, the designed particles exhibited significantly high payloads of drugs and dyes (up to 78 and 94%, respectively). Cellular studies also demonstrated exceptional biocompatibility and marked internalization into both human breast cancer MCF-7 and glioblastoma U-87 MG cells. Further, DOX also possessed a noticeable release from particles and accumulation in cell nuclei with increased incubation time in vitro. Ultimately, this work validates the controlled design and synthesis of PMO NPs using a polymer-scaffolding approach and highlights the potential of these materials as excellent delivery systems for combination therapy with high loading capability to improve the therapeutic index for cancers.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Polymer-Scaffolded Synthesis of Periodic Mesoporous Organosilica Nanomaterials for Delivery Systems in Cancer Cells

Attia

Akasov

Alexis

et al. 2020

ACS Biomater. Sci. Eng.

Self Cite

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show abstract

“…1 Schematic representative of functionalized GNPs and their biomedical applications (a), number of published papers in last decade on bone tissue engineering with GNPs (b) (Source: PubMed; https://www.ncbi.nlm.nih.gov , Keywords: gold and bone tissue). Reprinted from Ko et al [ 31 ], Khlebtsov et al [ 19 ], Heo et al [ 128 ], Han et al [ 21 ], Attia et al [ 178 ], John et al [ 23 ], Jiang et al [ 179 ], and Heo et al [ 169 ]. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)…”

Section: Introductionmentioning

confidence: 99%

A review on gold nanoparticles as an innovative therapeutic cue in bone tissue engineering: Prospects and future clinical applications

Yang,

Nah,

Lee

et al. 2024

Materials Today Bio

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Impact of polymer particle purification on the structural and catalytic properties of in situ generated gold nanoparticles

Jang,

Hou,

Yun

et al. 2023

J Polym Res

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In situ preparation of gold–polyester nanoparticles for biomedical imaging

Abstract: Hybrid gold-polyester nanoparticles were synthesized by UV irradiation of a gold salt and photoinitiator encapsulated in a polyester nanoparticle. The resulting materials exhibit excellent cellular imaging and surface plasmon resonance properties.

Cited by 6 publications

References 46 publications

Polymer-Scaffolded Synthesis of Periodic Mesoporous Organosilica Nanomaterials for Delivery Systems in Cancer Cells

Polymer-Scaffolded Synthesis of Periodic Mesoporous Organosilica Nanomaterials for Delivery Systems in Cancer Cells

A review on gold nanoparticles as an innovative therapeutic cue in bone tissue engineering: Prospects and future clinical applications

Impact of polymer particle purification on the structural and catalytic properties of in situ generated gold nanoparticles

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