In situ SAXRD study of sol–gel induced well‐ordered mesoporous bioglasses for drug delivery

Abstract

In this work, two systems of mesoporous bioglasses (MBGs) were sol-gel derived using block copolymer pluronic F127 and P123, respectively, as templates. A two-dimensional hexagonal (P6mm) mesoporous structure was obtained for the two systems, with d-spacing in (100) reflection of 8.49 nm for P123-templated MBG (P123-MBG) and 10.26 nm for F127-templated MBG (F127-MBG). The phase transformation behavior for the systems was elucidated using an in situ synchrotron small angle X-ray diffraction approach, with the corresponding mechanisms proposed. It was indicated that both systems go through a complicated phase transformation, from a disordered to a finely ordered hexagonal structure during the self-evaporation process. The surfactants not only acted as templates for the ordered structure, but also enhanced the rigidity of Si-O network, which prevented disruption to the ordered Si-O arrangement by the Ca(2+) and P-O group. In vitro bioactivity study showed similar bioactivity for both the P123-MBG and F127-MBG systems. Drug loading and release studies using a model metoclopramide drug showed that both MBGs presented better loading and release compared to normal bioglass (BG). The significantly higher loading and better sustained release for P123-MBG, compared to F127-MBG, is attributed to its higher pore volume and surface area.

Mesoporous bioactive glasses: structure characteristics, drug/growth factor delivery and bone regeneration application

“…Zhao et al [92] used different surfactants (P123 and F127) to prepare MBG and found that P123-MBG had higher pore volume and surface area than F127-MBG. The higher pore volume and surface area of P123-MBG led to significantly higher drug (metoclopramide)-loading efficiency (47.3%), compared with that for F127-MBG (16.6%) [92]. Arcos et al [28] prepared MBG by using three surfactants (CTAB, P123 and F127) and compared their drug (triclosan)-delivery ability.…”

Large-scale synthesis of hierarchically mesoporous phosphate nanocomposites using yeast cells as the template reactor

“…The above analysis also agrees with the frontal XRD and AFM results. These hierarchical mesoporous structures have potential applications as hosts in bonding or storing more drug molecules in the drug-release system [25,26]. The protein composition and structure in the different samples synthesized under the same conditions were analyzed by a Waters HPLC and the microscopic Raman spectrum.…”

Mesoporous Bioactive Glasses As Drug Delivery and Bone Tissue Regeneration Platforms

“…The potential mechanism of MBG with a slow drug release rate is due to the existence of a large number of Si-OH groups in MBG, which play an important role in interacting with gentamicin [29]. The surfactant plays an important role in influencing the loading and release of drug from MBG powders; P123-MBG has significantly higher loading efficiency for drug (47.3%) than F127-MBG (16.6), which is attributed to the higher pore volume and surface area for P123-MBG [36]. In another study, a photo responsive coumarin derivative was grafted onto MBG particles to develop photo controlled molecular gates.…”