Mesoporous Bioactive Glasses As Drug Delivery and Bone Tissue Regeneration Platforms

Abstract

The use of mesoporous bioactive glasses (MBG) for drug delivery and bone tissue regeneration has grown significantly over the past 5 years. In this article, we highlight recent advances made in the preparation of MBG particles, spheres, fibers and scaffolds. The advantages of MBG for drug delivery and bone scaffold applications are related to this material’s well-ordered mesopore channel structure, superior bioactivity and its capability to deliver both hydrophilic and hydrophobic drugs. A brief forward-looking perspective on the potential clinical applications of MBG in regenerative medicine is also discussed.

Mesoporous bioactive glasses: structure characteristics, drug/growth factor delivery and bone regeneration application

“…In their study, ultrathin MBG fibres, with hierarchical nanoporosities and high matrix homogeneities, were synthesized using the electrospinning technique and P123-PEO co-templates [61]. At the same time, by controlling the electrospinning conditions, they were able to prepare MBG fibres with hollow cores and mesoporous walls; these fibres were found to be highly bioactive for drug delivery [14,68].…”

Novel nanocomposite biomaterials with controlled copper/calcium release capability for bone tissue engineering multifunctional scaffolds

“…Both inorganic and organic biomaterials (such as ceramics and polymers, respectively) have been widely used to prepare scaffolds with those requirements [3,[5][6][7][8][9]. Among ceramics, bioactive glasses-particularly Bioglass w 45S5-exhibit interesting properties for BTE [7,8,[10][11][12][13][14], such as the promotion of the formation of bone-like hydroxyapatite (HA) layers on the biomaterial surface [15,16], and their osteoconductive and osteoinductive characteristics [6,17,18]. In addition, reports indicate that dissolution products from bioactive glasses upregulate the expression of genes that control osteogenesis [13,[17][18][19] and induce proangiogenic effects by stimulating the production of vascular endothelial growth factor (VEGF) [20,21], the secretion of angiogenic growth factors in fibroblasts [22,23], the proliferation of endothelial cells [22][23][24] and the formation of endothelial tubules [22].…”

Ag-loaded mesoporous bioactive glasses against <i>Enterococcus faecalis</i> biofilm in root canal of human teeth

“…Recent studies had tried to combine the calcium-silicate with antibacterial ions to produce new antibacterial bio-materials 14) . Mesoporous bioactive glasses (MBGs), a new class of BGs developed in 2004, have received much attention for the applications in drug delivery and bone tissue regeneration 15) . MBGs possess well ordered mesoporous channel structure, highly specific surface area and pore volume, which enhances their biological behaviour 16) .…”