<i>In vitro</i> activities of <i>Ceiba speciosa</i> (A.St.-Hil) Ravenna aqueous stem bark extract

Dörr, Juliana Andréa; Bitencourt, Shanna; Bortoluzzi, Luisa Donato; Alves, Celso; Silva, Joana; Stoll, Stefani Natali; Pintéus, Susete; Boligon, Aline Augusti; Santos, Roberto Christ Vianna; Laufer, Stefan; Pedrosa, Rui; Goettert, Márcia Inês

doi:10.1080/14786419.2018.1478823

Cited by 10 publications

(10 citation statements)

References 16 publications

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“…Furthermore, the desire to increase fruit and vegetable consumption in the human diet is partially due to the favorable effects of beneficial antioxidants found in these foods on health promotion. Previous research on C. speciosa fruit and leaves has revealed anti-inflammatory and antioxidant properties [ 11 , 13 , 14 , 15 ], but whether FPCS, in addition to its role as a color additive, has similar activities was unknown before the current study.…”

Section: Discussionmentioning

confidence: 96%

“…Thus, a complex polymer with a backbone made up of glucuronosyl and mannosyl units has been found in the gum exudate, which is exuded when the trunk is injured [ 11 ]. C. speciosa fruit elicits anti-inflammatory and antioxidant responses via phenolic compounds that inhibit hydrogen peroxide-induced mitochondrial membrane depolarization and caspase-9 activation [ 11 , 13 ]. Preliminary research suggests that C. speciosa leaf extracts have antioxidant, anti-inflammatory, antipyretic, antibacterial and antifungal functions [ 14 , 15 ], while its seed oil shows hypoglycemic and anti-obesity properties [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

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Pigment of Ceiba speciosa (A. St.-Hil.) Flowers: Separation, Extraction, Purification and Antioxidant Activity

et al. 2022

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In this work, the extraction procedure of a natural pigment from the flower of Ceiba speciosa (A. St.-Hil.) was optimized by response surface methodology. It is the first time that the extraction of the flower pigment of C. speciosa (FPCS) has been reported, along with an evaluation of its stability and biological activity under various conditions, and an exploration of its potential use as a food additive and in medicine. Specifically, the effects of ethanol concentration, solid–liquid ratio, temperature and time on the extraction rate of FPCS were determined using a Box–Behnken design. The optimum extraction conditions for FPCS were 75% ethanol with a solid–liquid ratio of 1:75 mg/mL) at 66 °C for 39 min. The purification of FPCS using different macroporous resins showed that D101 performed best when the initial mass concentration of the injection solution was 1.50 mg/mL, resulting in a three-fold increase in color value. The yield of dry flowers was 9.75% of fresh petals and the FPCS extraction efficiency was 43.2%. The effects of light, solubility, pH, temperature, sweeteners, edible acids, redox agents, preservatives and metal ions on FPCS were also investigated. Furthermore, the characteristics of FPCS were determined by spectrophotometry at a specific wavelength using the Lambert–Beer law to correlate the mass of FPCS with its absorbance value. An acute toxicological test performed according to Horne’s method showed that FPCS is a non-toxic extract and thus may be used as a food additive or in other ingestible forms. Finally, western blotting showed that FPCS prevents lipopolysaccharide-induced hippocampal oxidative stress in mice. The study suggests that FPCS may function as an antioxidant with applications in the food, cosmetics and polymer industries.

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Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Pigment of Ceiba speciosa (A. St.-Hil.) Flowers: Separation, Extraction, Purification and Antioxidant Activity

et al. 2022

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“…To our knowledge, this is the first report on the antioxidant activity of fixed oil. Previously, Dörr et al [35] revealed that C. speciosa aqueous steam bark extract exerted a promising DPPH radical scavenging potential. A promising DPPH radical scavenging effect was observed, also by Krüger Cardoso Malheiros et al [36], who found percentage of 85.13 and 88.95% at concentration of 50 µg/mL for raw aqueous bark extract and ethanol extract, respectively.…”

Section: Antioxidant Activitymentioning

confidence: 99%

Ceiba speciosa (A. St.-Hil.) Seeds Oil: Fatty Acids Profiling by GC-MS and NMR and Bioactivity

et al. 2020

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This study aimed to evaluate the chemical composition by gas chromatography-mass spectrometry (GC-MS) and Nuclear Magnetic Resonance (NMR) analyses, the antioxidant activities evaluated by different in vitro assays namely 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS), Ferric Reducing Ability Power (FRAP), and β-carotene bleaching tests, and the inhibitory effects of enzymes linked to obesity (lipase, α-amylase, and α-glucosidase) of fixed seed oil of Ceiba speciosa (A. St.-Hil.). Fourteen compounds were identified. Linoleic acid (28.22%) was the most abundant followed by palmitic acid (19.56%). Malvalic acid (16.15%), sterculic acid (11.11%), and dihydrosterculic acid (2.74%) were also detected. C. speciosa fixed oil exerted a promising ABTS radicals scavenging activity with an IC50 value of 10.21 µg/mL, whereas an IC50 of 77.44 µg/mL against DPPH+ radicals was found. C. speciosa fixed oil inhibited lipase with an IC50 value of 127.57 µg/mL. The present investigation confirmed the functional properties of C. speciosa fixed oil, and proposes its use as valuable source of bioactive constituents.

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“…The C. grandifolia aqueous extract was screened for inhibition of p38 mitogen-activated protein kinase (MAPK) and Janus kinase 3 (JAK3). The inhibitory potency was assessed by previously established ELISA assays measuring the inhibition of p38α-mediated ATF-2 phosphorylation and JAK3-mediated ATP phosphorylation (Anastassiadis et al 2011;Dörr et al 2018;Goettert et al 2011Goettert et al , 2012. The half-maximal inhibitory concentration (IC 50 ) of the extract was calculated.…”

Section: Cell-free Kinase Assaymentioning

confidence: 99%

Antimicrobial and antileukemic effects: in vitro activity ofCalyptranthes grandifoliaaqueous leaf extract

Majolo

Bitencourt

Monteiro

et al. 2020

Journal of Toxicology and Environmental Health, Part A

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Natural products are still a promising source of bioactive molecules. Food and Drug Administration data showed that approximately 49% of the approved molecules originate naturally or chemicallyresemble these substances, of which more than 70% are being used in anticancer therapy. It is noteworthy that at present there are no scientific studies to prove the effectiveness and safety of a number of plants used in folk medicine such as in the case of Calyptranthes grandifolia O. Berg (Myrtaceae) originally from South America. The aim of the present study was to determine the biological potential and toxicological effects of the aqueous leaf extract of C. grandifolia. The main detected phytoconstituents were condensed tannins and flavonoids and a high quantity of polyphenols. Regarding the antimicrobial potential, the extract exerted inhibitory activity against Pseudomonas aeruginosa. The results also revealed the extract induced DNA damage in a concentration-dependent manner in RAW 264.7 cells. In addition, C. grandifolia produced cytotoxicity in leukemia cell lines (HL60 and Kasumi-1) without affecting isolated human lymphocytes but significantly inhibited JAK3 and p38α enzyme activity. Taken together, these findings add important information on the biological and toxicological effects of C. grandifolia, indicating that aqueous extract may be a source of natural antimicrobial and antileukemic constituents.

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In vitro activities of Ceiba speciosa (A.St.-Hil) Ravenna aqueous stem bark extract

Cited by 10 publications

References 16 publications

Pigment of Ceiba speciosa (A. St.-Hil.) Flowers: Separation, Extraction, Purification and Antioxidant Activity

Pigment of Ceiba speciosa (A. St.-Hil.) Flowers: Separation, Extraction, Purification and Antioxidant Activity

Ceiba speciosa (A. St.-Hil.) Seeds Oil: Fatty Acids Profiling by GC-MS and NMR and Bioactivity

Antimicrobial and antileukemic effects: in vitro activity ofCalyptranthes grandifoliaaqueous leaf extract

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