<i>In vitro</i> alterations in dental enamel exposed to acidic medicines

Valinoti, Ana Carolina; Pierro, Viviane Santos da Silva; Silva, Eduardo Moreira da; Maia, Lucianne Cople

doi:10.1111/j.1365-263x.2010.01104.x

Cited by 46 publications

(68 citation statements)

References 32 publications

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“…Other in vitro studies have also demonstrated that Claritin® may reduce enamel hardness (18)(19)(20) and increase surface roughness (17). In the present study, the varnishes were applied once and removed after 6 h of application to simulate the clinical condition, since the emphasis was allowing the chemical effect of the varnish components, rather than the mechanical protection.…”

Section: Discussionmentioning

confidence: 99%

Fluoride Varnishes against Dental Erosion Caused by Soft Drink Combined with Pediatric Liquid Medicine

et al. 2017

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The present study evaluated the effect of NaF and CPP-ACP/NaF varnishes to reduce erosion produced by soft drink (SD) combined or not with pediatric liquid medicine. Enamel specimens were pre-treated with fluoride varnish, according to the following groups: NaF varnish (Duraphat®) or CPP-ACP/NaF varnish (MI varnish TM ). Two types of erosive cycles were made: by soft drink erosion (SDE) or by pediatric liquid medicine plus soft drink erosion (PLM/SDE). Bovine enamel specimens were randomly assigned in six groups (n=10): G1=NaF + SDE; G2=CPP-ACP/NaF + SDE; G3=Distilled and deionized (DD) water + SDE; G4=NaF + PLM/SDE; G5=CPP-ACP/NaF + PLM/SDE and G6=DD water + PLM/SDE. Before treatments, the sample surface was divided in two areas (unexposed area-UA and exposed area-EA). The specimens were evaluated by 3D non-contact profilometry technique to determinate tooth structure loss (TSL) and surface roughness (Sa). Scanning electron microscopy (SEM) analysis was also performed. After SDE, G2 presented the lowest TSL values compared to G3 (p=0.008). G1 and G2 did not differ between them (p=0.203) and no groups differed among them despite Sa. Regarding TSL and Sa, G4 and G5 differed from G6 (p=0.0001), but not between them (p=1.00). Examining 3D and SEM images, the greatest differences between UA and EA were observed for G3 and G6. CPP-ACP/ NaF varnish seems to be a promising treatment to reduce enamel loss from the erosion produced by a soft drink. Both varnishes also showed capacity to reduce TSL and Sa after erosion by soft drink combined to pediatric liquid medicine.

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Section: Discussionmentioning

confidence: 99%

Fluoride Varnishes against Dental Erosion Caused by Soft Drink Combined with Pediatric Liquid Medicine

et al. 2017

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“…Some in vitro researches reported that medications can affect enamel hardness, and cause morphological and roughness alterations (5,9). Nevertheless, the results of these studies are limited to a small number of medicines, and the literature is scarce of articles that investigate the effects of medications on permanent and deciduous tooth enamel (9).…”

Section: Introductionmentioning

confidence: 99%

“…Nevertheless, the results of these studies are limited to a small number of medicines, and the literature is scarce of articles that investigate the effects of medications on permanent and deciduous tooth enamel (9).…”

Section: Introductionmentioning

confidence: 99%

“…Acidic preparations are often necessary for drug dispersion, chemical stability maintenance, to ensure physiological compatibility and to improve flavor (6,7). In addition to the acidic components, other factors such as prolonged and frequent ingestion (i.e., two or more times daily), bedtime and between meals consumption, high viscosity and the collateral effect of reduced salivary flow, may contribute to increase the risk for medication-induced dental erosion (1,2,9).…”

Section: Introductionmentioning

confidence: 99%

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In Vitro Erosive Effect of Pediatric Medicines on Deciduous Tooth Enamel

et al. 2014

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This study evaluated, in vitro, the erosive potential of pediatric liquid medicines in primary tooth enamel, depending on the exposure time. Sixty deciduous incisors were randomly assigned to 4 groups (n=15), according to the immersion solutions: guaifenesin; ferrous sulfate; salbutamol sulfate and artificial saliva. The immersion cycles in the medicines were undertaken under a 1-min agitation, which wasperformed three times daily, during 28 days. Surface microhardness was measured at 7,14, 21 and 28 days. The titratable acidity and buffering capacity of the immersion media were determined. Data were analyzed by Analysis of Variance and Tukey's test (α=0.05). Salbutamol sulfate caused a gradual loss in enamel microhardness deciduous, observed at all times (p<0.005). Exposure to guaifenesin or ferrous sulfate resulted in significant decrease of enamel microhardness only after 28 days (p<0.005). In the control group (artificial saliva), microhardness did not changed (p>0.005) at any of the studied times. Scanning Electron Microscopy (SEM) images revealed that after 28 days the surfaces clearly exhibited structural loss, which was unlike those immersed in artificial saliva. Erosion of deciduous enamel was dependent on the type of medicine and exposure time.

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“…Valinoti et al 13) told that bovine enamel exposed to 3 kinds of children's syrups demonstrated erosive pattern by means of a scanning electron microscope. In addition, Sunitha et al 14) said inappropriate use of liquid medicines would have enormous potential to induce dental caries as syrups such as antipyretic·analgesic medicines, cough syrup with 10% of sucrose made experimental plaque's pH lower.…”

Section: Introductionmentioning

confidence: 99%

Effects of the Enamel Erosion Caused by Certain Antipyretic and Analgesic Medicines for Children

Cheun¹,

Jeong²,

Ahn³

et al. 2016

Journal of dental hygiene science

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This study was conducted to provide basic understanding regarding possible enamel erosion by three kinds of fist-aid antipyretic and analgesic medicines over a period of time, with comparison and analysis of the resulting deciduous teeth surface and microhardness changes. The analysis was performed using energy dispersive X-ray spectroscopy (EDX) and scanning electron microscope (SEM) to examine the surface erosion and changes. The Kruskal-Wallis test show differences in surface erosion and changes after 3, 5 and 8 days of treatment as well as before and after the treatment in each group. According to the results, there was no significant difference in the early deciduous teeth enamel surface microhardness (p＞0.01). However there were signigicant changes after 3, 5, and 8 days (p＜0.01). Calcim (Ca) and phosphorous (P) analysis using EDX showed significant differences in the enamel characteristics according to each tissue area after 8 days (p＜0.05), but there was no significant difference in any of the areas for P content (p＞0.05). In the surface observation with the SEM treatment with Children's Tylenol Ⓡ tablet, which has the lowest pH, looked the roughest, followed by Brufen syrup for children and Children's Tylenol Ⓡ suspension. Based on these results, it should be considered that antipyretic and analgesic medicines for children, which have lower pH values, may cause tooth erosion. Hence, it is necessary to give special attention to oral hygiene in young children or infants by brushing their teeth after such drugs are administered.

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In vitro alterations in dental enamel exposed to acidic medicines

Abstract: Dimetapp(®) (lowest pH and viscosity) and deionized water (control) showed the most pronounced erosive patterns. Klaricid(®) (highest pH and viscosity) presented an in vitro protective effect against acid attacks perhaps due to its mineral content and viscosity.

Cited by 46 publications

References 32 publications

Fluoride Varnishes against Dental Erosion Caused by Soft Drink Combined with Pediatric Liquid Medicine

Fluoride Varnishes against Dental Erosion Caused by Soft Drink Combined with Pediatric Liquid Medicine

In Vitro Erosive Effect of Pediatric Medicines on Deciduous Tooth Enamel

Effects of the Enamel Erosion Caused by Certain Antipyretic and Analgesic Medicines for Children

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