2021
DOI: 10.21873/invivo.12677
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In VitroAnalysis of the Cytocompatibility of a Novel Porcine Aortic Patch for Vascular Reconstruction

Abstract: Background/Aim: Cardiovascular diseases are one of the most common causes of morbidity and mortality in the world. In the case of severe arteriosclerotic damage, surgical treatment is necessary. Although the use of autologous vessels is still considered to be the gold standard, sufficient autologous vessels for transplantation are lacking. Materials and Methods: In the present study, histological examination and in vitro cytotoxicity analysis according to DIN EN ISO 10993-5 were performed on a newly developed … Show more

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“…To evaluate the cytocompatibility of the BBS combined with 18 coatings based on the bioactive cations strontium (Sr 2+ ) and magnesium (Mg 2+ ) as well as PLGA coating, XTT cell viability assays were conducted using L929-fibroblasts and Normal Human Osteoblasts (NHOsts) following the DIN ISO 10993-5 protocol as previously described ( Gogele et al, 2020 ; Schroepfer et al, 2020 ; Pantermehl et al, 2022 ; Ren et al, 2023 ). Based on the cytocompatibility analyses, the material types with a viability above 70% compared to the negative control group as defined within the DIN ISO norm were considered cytocompatible and used for further material characterizations and in vivo studies.…”
Section: Resultsmentioning
confidence: 99%
“…To evaluate the cytocompatibility of the BBS combined with 18 coatings based on the bioactive cations strontium (Sr 2+ ) and magnesium (Mg 2+ ) as well as PLGA coating, XTT cell viability assays were conducted using L929-fibroblasts and Normal Human Osteoblasts (NHOsts) following the DIN ISO 10993-5 protocol as previously described ( Gogele et al, 2020 ; Schroepfer et al, 2020 ; Pantermehl et al, 2022 ; Ren et al, 2023 ). Based on the cytocompatibility analyses, the material types with a viability above 70% compared to the negative control group as defined within the DIN ISO norm were considered cytocompatible and used for further material characterizations and in vivo studies.…”
Section: Resultsmentioning
confidence: 99%