2009
DOI: 10.1111/j.1600-0765.2008.01159.x
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In vitro and in vivo cytokeratin patterns of expression in bioengineered human periodontal mucosa

Abstract: The results indicate that this model of human oral mucosa, constructed using fibrin-agarose scaffolds, shows similarities to native oral mucosa controls and imply that bioengineered oral mucosa substitutes could eventually be used clinically.

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Cited by 48 publications
(56 citation statements)
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“…Upregulation of CK-7 is also seen in the stratified oral mucosal epithelium ex vivo , even though this epithelium is devoid of CK-7 in vivo (Garzon et al, 2009). Thus, the CK-7+/UEA-1− cells at the leading edge in the primary cultures could represent cells with reactive upregulation of CK-7 rather than true goblet cells.…”
Section: Discussionmentioning
confidence: 99%
“…Upregulation of CK-7 is also seen in the stratified oral mucosal epithelium ex vivo , even though this epithelium is devoid of CK-7 in vivo (Garzon et al, 2009). Thus, the CK-7+/UEA-1− cells at the leading edge in the primary cultures could represent cells with reactive upregulation of CK-7 rather than true goblet cells.…”
Section: Discussionmentioning
confidence: 99%
“…Aside from neural tissues, agarose has been used to investigate other tissues, often as part of a mixture. The Campos group has used a fibrin-agarose material for engineering a variety of tissues including peripheral nerves, skin, oral mucosa, and corneas [40][41][42][43][44][45]. Others are investigating collagen-agarose gels for skin tissue engineering [46] or in combination with methylcellulose and chitosan for bone tissue engineering [47].…”
Section: Agarose As a Tissue Engineering Scaffoldmentioning
confidence: 99%
“…28,29 For these reasons, a novel agarose gel model was developed by using 1% agarose gel to mimic the soft-tissue and bone defects for measuring the volume and distribution of ejected bone graft substitutes for evaluation of the feasibility of the microinjector. The density of 1% agarose gel is similar to the softtissue and bone defects.…”
Section: Discussionmentioning
confidence: 99%
“…The feasibility of the dental microinjector indicated that this method can replace the traditional GBR method, which has the disadvantages of requiring a suitable barrier membrane and a two-stage surgical process. 28,29 Compared to the traditional GBR method, by using the novel microinjector, no barrier membrane is necessary, only a one-step procedure is necessary, and the injected wound is very small (Figure 4). The feasibility of the microinjector was demonstrated by the agarose gel model and suggests that it is worthy of further clinical applications.…”
Section: Discussionmentioning
confidence: 99%