In VitroandIn VivoAntitumoral Phenanthrenes from the Aerial Parts ofDendrobium nobile

Abstract

Two phenanthrenes were isolated from the aerial part of Dendrobium nobile Lindl. and their structures were identified to be 4,7-dihydroxy-2-methoxy-9,10-dihydrophenanthrene (1) and denbinobin (2), among which the former has been first isolated from this plant. These two compounds were found to be cytotoxic against A549 (human lung carcinoma), SK-OV-3 (human ovary adenocarcinoma), and HL-60 (human promyelocytic leukemia) cell lines. Compound 1 also showed antitumor activity on the life span of ICR mice intraperitoneally implanted with 1 x 10(6) cells of sarcoma 180.

In vitro antioxidant activities of a water-soluble polysaccharide derived from Dendrobium nobile Lindl. extracts

“…Among the Dendrobium genus, most studies have focused on the bioactivity and structural types of some small molecules, such as bibenzyl, phenanthrene, anthracene, fluorene, coumarin, flavone, cinnamate, sesquiterpene, sterol, fatty acid, and alkaloids [2][3][4][5][6][7][8][9][10][11][12]. However, the polysaccharide constituents were much less investigated.…”

Anti-inflammatory phenanthrene derivatives from stems of Dendrobium denneanum

“…Phenanthrenes have been found to have various biological activities such as anti-inflammatory (Yang et al, 2006a), cytotoxic (Lee et al, 2009), antifibrotic (Yang et al, 2007a), anticancer (Lee et al, 1995), and antimicrobial (Adriána et al, 2008) effects. To determine if the isolated compounds were responsible for the antiinflammatory effects of this plant in clinical use, compounds 1-12 (Fig.…”

Immune stimulating activity of water-soluble polysaccharide fractions from Dendrobium nobile Lindl.

“…To elucidate the pharmacological mechanism of D. nobile Lindl. much research has been carried out on the low molecular compounds, such as bibenzyls (Zhang et al, 2006), alkaloids (Liu and Zhao, 2003) and phenanthrenes (Lee et al, 1995;Yang et al, 2007;Wang et al,1985). As for the compounds of polysaccharides from D. nobile Lindl.…”