In Vitro and In Vivo Aldose Reductase Inhibitory Activity of Standardized Extracts and the Major Constituent of Andrographis paniculata

Veeresham, Ciddi; Swetha, Ettireddy; Rao, Ajmeera Rama; Asres, Kaleab

doi:10.1002/ptr.4722

Cited by 20 publications

(12 citation statements)

References 24 publications

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“…In a study, the methanol extract of A. paniculata and AGL were found to decrease galactitol accumulation in rat lens ( in vitro ) and galactosemic rat model ( in vivo ) ( Veeresham et al, 2013 ). Zhou et al (2013) also introduced two important AGL derivatives (compounds 1 and 7, Figure 1 ) having antidiabetic activity.…”

Section: Resultsmentioning

confidence: 99%

Andrographolide, a New Hope in the Prevention and Treatment of Metabolic Syndrome

Islam

2017

Front. Pharmacol.

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Recently, the use of plant-derived medicines is increasing interest in the prevention and treatment of a variety of disorders including metabolic syndromes. Metabolic syndrome is one of the major risk factors for cardiovascular diseases (CVDs) and incidence of mortality worldwide. Scientific evidence suggests that Andrographis paniculata and its derived components, especially andrographolide (AGL) and its analogs/derivatives have a broad spectrum of biological activities. This review aims to sketch the activity of AGL and its analogs/derivatives against the components of metabolic syndromes such as diabetes, hyperlipidemia, hypertension, and obesity. Additionally, AGL activity against CVDs is also summarized. The finding suggests that AGL and its analogs/derivatives have a potential role in the management of metabolic syndrome; however, more studies should be conducted to evaluate their effectiveness.

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Section: Resultsmentioning

confidence: 99%

Andrographolide, a New Hope in the Prevention and Treatment of Metabolic Syndrome

Islam

2017

Front. Pharmacol.

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“…Hyperglycemia due to diabetes causes the activation of aldose reductase that leads to sorbitol [39][40][41][42][43] and fructose production. These two products can induce oxidative stress leading to alteration in normal physiological functions.…”

Section: Discussionmentioning

confidence: 99%

Hypoglycemic action of vitamin K1 protects against early-onset diabetic nephropathy in streptozotocin-induced rats

et al. 2015

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“…Veeresham et al ., reported that the methanolic and standardized extracts of Andrographis paniculata (Burm. f.) Wall.…”

Section: Introductionmentioning

confidence: 99%

Aldose Reductase Inhibitors of Plant Origin

Veeresham

Rao

Asres

2013

Phytotherapy Research

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Diabetic complications are attributed to hyperglycaemic condition which is in turn associated with the polyol pathway and advanced glycation end products. Aldose reductase (AR) is the principal enzyme of polyol pathway which plays a vital role in the development of diabetic complications. AR inhibitory activity can be screened by both in vitro and in vivo methods. In vitro assays for AR enzyme are further classified on the basis of the source of enzyme such as rat lens, rat kidney, cataracted human eye lens, bovine eyes and human recombinant AR enzymes, whereas the in vivo model is based on the determination of lens galactitol levels. A number of synthetic AR inhibitors (ARIs) including tolrestat and sorbinil have been developed, but all of these suffer from drawbacks such as poor permeation and safety issues. Therefore, pharmaceutical companies and many researchers have been carrying out research to find new, potent and safe ARIs from natural sources. Thus, many naturally occurring compounds have been reported to have AR inhibitory activity. The present review attempts to highlight phytochemicals and plant extracts with potential AR inhibitory activity. It also summarizes the classes of compounds which have proven AR inhibitory activity. Phytochemicals such as quercetin, kaempferol and ellagic acid are found to be the most promising ARIs. The exhaustive literature presented in this article clearly indicates the role of plant extracts and phytochemicals as potential ARIs.

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In Vitro and In Vivo Aldose Reductase Inhibitory Activity of Standardized Extracts and the Major Constituent of Andrographis paniculata

Cited by 20 publications

References 24 publications

Andrographolide, a New Hope in the Prevention and Treatment of Metabolic Syndrome

Andrographolide, a New Hope in the Prevention and Treatment of Metabolic Syndrome

Hypoglycemic action of vitamin K1 protects against early-onset diabetic nephropathy in streptozotocin-induced rats

Aldose Reductase Inhibitors of Plant Origin

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