<i>In-Vitro</i> and <i>In-Vivo</i> Trans-Scalp Evaluation of an Intracranial Pressure Implant at 2.4 GHz

Kawoos, Usmah; Tofighi, Mohammad; Warty, R.; Kralick, Francis; Rosen, A.

doi:10.1109/tmtt.2008.2004253

Cited by 69 publications

(29 citation statements)

References 30 publications

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“…Early attempts at passive (non-tethered) solutions operated at low frequencies, which require relatively large components and translate to sensor size in the cm 3 range [3][4][5][6][7][8][9][10] . Although their development has ceased, emerging wireless solutions specifically for ICP monitoring have also had large sizes, as they use batteries and active circuitry to power the sensor device [11][12][13][14][15][16][17][18] . The smallest wireless pressure monitoring device to date is a battery-powered wireless sensor that researchers have fit into a 1-mm 3 package for intraocular applications 19 .…”

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confidence: 99%

Continuous wireless pressure monitoring and mapping with ultra-small passive sensors for health monitoring and critical care

et al. 2014

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Continuous monitoring of internal physiological parameters is essential for critical care patients, but currently can only be practically achieved via tethered solutions. Here we report a wireless, real-time pressure monitoring system with passive, flexible, millimetre-scale sensors, scaled down to unprecedented dimensions of 1 Â 1 Â 0.1 cubic millimeters. This level of dimensional scaling is enabled by novel sensor design and detection schemes, which overcome the operating frequency limits of traditional strategies and exhibit insensitivity to lossy tissue environments. We demonstrate the use of this system to capture human pulse waveforms wirelessly in real time as well as to monitor in vivo intracranial pressure continuously in proof-of-concept mice studies using sensors down to 2.5 Â 2.5 Â 0.1 cubic millimeters. We further introduce printable wireless sensor arrays and show their use in real-time spatial pressure mapping. Looking forward, this technology has broader applications in continuous wireless monitoring of multiple physiological parameters for biomedical research and patient care.

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confidence: 99%

Continuous wireless pressure monitoring and mapping with ultra-small passive sensors for health monitoring and critical care

et al. 2014

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“…In a previous study [1], a device (featuring subdural placement of a biomedical microelectromechanical system (MEMS) capacitive sensor) operating at 2.4 GHz was developed. The device was implanted in a canine model for a static test, and hypo-and hyperventilation were used to effect variations in ICP.…”

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confidence: 99%

Dynamic study of wireless intracranial pressure monitoring of rotational head injury in swine model

Meng¹,

Browne²,

Huang³

et al. 2012

Electron. Lett.

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For what is believed to be for the first time, the dynamic study of wireless intracranial pressure measurements in a swine model of traumatic brain injury is described. This achieves an extremely important milestone, since the measurements demonstrate the system's robustness, and the feasibility of acquiring wireless readings of the intracranial pressure resulting from non-impact rotational head injury in swine. The fully implanted device uses a capacitive pressure sensor modulating an RF oscillator, coupled to a planar inverted-F antenna. The results match well those obtained from a standard fibre-optic based (tethered) commercial intracranial pressure monitor, as well as published literature data, and may enable a future trend in the use of implantable wireless systems for research or clinical diagnoses.Introduction: Increased intracranial pressure (ICP) is an important component of secondary brain injury following traumatic brain injury (TBI). Indeed, the prevention and control of increased ICP is one of the fundamental therapeutic goals following TBI across a range of severities. Standard commercially available ICP measuring equipment uses a tethered fibre-optic probe that penetrates the brain, which can remain implanted in TBI patients or animals for only a short period of time. Therefore, a small fully embedded wireless ICP device, implanted during a straightforward procedure, drastically simplifies subsequent clinical management of brain injury patients. In particular, by offering a means for semi-invasive and long-term pressure measurement, this technology may guide subsequent neurosurgical decisions and reduce the risk of infection in a neurointensive care setting.In a previous study [1], a device (featuring subdural placement of a biomedical microelectromechanical system (MEMS) capacitive sensor) operating at 2.4 GHz was developed. The device was implanted in a canine model for a static test, and hypo-and hyperventilation were used to effect variations in ICP. A MEMS sensor was preferred over a piezoresistive one [2] for its temperature stability and power consumption considerations. The in vitro and in vivo results demonstrated the feasibility of microwave pressure monitoring through scalp, long-term device integrity, and repeatability of pressure measurements

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“…In epidural detection the sensor maintains a contact with the dural mata and relies on dural deflection. [32] function of wavelength λ. This attenuation is the superposition of absorption (A λ ) and scattering (S λ ) of light with wavelength λ.…”

Section: Optical Scattering [21-27]mentioning

confidence: 99%

“…7 A Wireless embedded intracranial pressure monitoring device -implantable at bed-side [30][31][32][33][34] Increased Intracranial Pressure (ICP) caused by brain diseases or head injury is usually the final common cause of permanent disability and death. A major focus is thus required for measurement and control of ICP for optimum care of both acutely and chronically ill patients.…”

Section: Introductionmentioning

confidence: 99%

The Role of Engineering Principles in the Medical Utilization of Electromagnetic Energies from kHz to Visible Light - Examples

Rosen

Rosen²

2009

J Infrared Milli Terahz Waves

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The use of RF/microwaves in medicine has increased dramatically over the last ten years. RF and microwave therapies for the treatment of cancer in humans are well documented, and are presently used in many cancer centers. RF treatment for supra ventricular arrhythmias, and more recently for the treatment of ventricular tachycardia, are currently employed by major hospitals. RF/microwave are also used in human subjects for the treatment of benign prostatic hyperplasia (BPH). In the last few years, several otolaryngological centers have been utilizing RF to treat upper airway obstruction and to alleviate sleep apnea. Many centers also utilize RF for the treatment of gastro-esophageal disease (GERD), for pain management, and for endometrial ablation. Balloon microwave catheters for ablating solid tumors, then forming cavities in those tumors for the local delivery of therapeutic agents, are currently being investigated. New modalities are being studied, such as RF/microwave for the enhancement of drug absorption and microwave septic wound treatment, microwave imaging for the detection of breast cancer, epidemiological studies on the effects of rats' exposure to microwave, as well as tissue regeneration using electromagnetic fields. In addition, technology is presently being developed that allows for permanent implantation of microwave wireless sensors in humans. A permanently implantable intra-cranial pressure monitor is one such application of the latter technology. Many more areas of research are currently being investigated, a partial list of which is summarized here. This paper is a synopsis of a Plenary presentation given at IRMMW-THz 2008, Sept. 16, 2008 CA, USA and is representative of the conference theme, "THz for Life" which highlights cross-over applications from physics and engineering into biology and medicine. Although it is not specifically targeted at short wavelength RF it introduces therapies that may ultimately benefit from infrared and THz techniques and therefore is included in this special conference edition of JIMT (voc. ed.).

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In-Vitro and In-Vivo Trans-Scalp Evaluation of an Intracranial Pressure Implant at 2.4 GHz

Cited by 69 publications

References 30 publications

Continuous wireless pressure monitoring and mapping with ultra-small passive sensors for health monitoring and critical care

Continuous wireless pressure monitoring and mapping with ultra-small passive sensors for health monitoring and critical care

Dynamic study of wireless intracranial pressure monitoring of rotational head injury in swine model

The Role of Engineering Principles in the Medical Utilization of Electromagnetic Energies from kHz to Visible Light - Examples

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