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While neural networks have achieved vastly enhanced performance over traditional iterative methods in many cases, they are generally empirically designed and the underlying structures are difficult to interpret. The algorithm unrolling approach has helped connect iterative algorithms to neural network architectures. However, such connections have not been made yet for blind image deblurring. In this paper, we propose a neural network architecture that advances this idea. We first present an iterative algorithm that may be considered a generalization of the traditional total-variation regularization method on the gradient domain, and subsequently unroll the half-quadratic splitting algorithm to construct a neural network. Our proposed deep network achieves significant practical performance gains while enjoying interpretability at the same time. Experimental results show that our approach outperforms many state-of-the-art methods.

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Cell nuclei detection is a challenging research topic because of limitations in cellular image quality and diversity of nuclear morphology, i.e. varying nuclei shapes, sizes, and overlaps between multiple cell nuclei. This has been a topic of enduring interest with promising recent success shown by deep learning methods. These methods train Convolutional Neural Networks (CNNs) with a training set of input images and known, labeled nuclei locations. Many such methods are supplemented by spatial or morphological processing. Using a set of canonical cell nuclei shapes, prepared with the help of a domain expert, we develop a new approach that we call Shape Priors with Convolutional Neural Networks (SP-CNN). We further extend the network to introduce a shape prior (SP) layer and then allowing it to become trainable (i.e. optimizable). We call this network tunable SP-CNN (TSP-CNN). In summary, we present new network structures that can incorporate 'expected behavior' of nucleus shapes via two components: learnable layers that perform the nucleus detection and a fixed processing part that guides the learning with prior information. Analytically, we formulate two new regularization terms that are targeted at: 1) learning the shapes, 2) reducing false positives while simultaneously encouraging detection inside the cell nucleus boundary. Experimental results on two challenging datasets reveal that the proposed SP-CNN and TSP-CNN can outperform state-of-the-art alternatives.