<i>IN VITRO</i> AND <i>IN VIVO</i> STUDIES OF THE BEHAVIOR OF CANINE ERYTHROCYTE‐ISOANTIBODY SYSTEMS*

Swisher, Scott N.; Young, Lawrence E.; Trabold, Norma C.

doi:10.1111/j.1749-6632.1962.tb34618.x

Cited by 46 publications

(35 citation statements)

References 16 publications

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“…Interestingly, the majority (67%) of hospitals reported waiting ≥3 days after the first transfusion to perform a cross‐match procedure in both cats and dogs, compared to 33% of hospitals that wait ≥5 days. While previous studies indicate that induced alloantibodies to DEA 1.1 are present 9 days after transfusion in dogs, the majority of hospitals indicated preferring to perform cross‐match testing sooner.…”

Section: Discussionmentioning

confidence: 99%

Transfusion practice in dogs and cats: an Internet‐based survey

Jagodich

Holowaychuk

2016

J Vet Emergen Crit Care

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Section: Discussionmentioning

confidence: 99%

Transfusion practice in dogs and cats: an Internet‐based survey

Jagodich

Holowaychuk

2016

J Vet Emergen Crit Care

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“…18 Galgos negative for DEA 4 were not found among our study population, which was not surprising as up to 98-100% of the general dog population expresses this antigen. 2,[11][12][13]18,[20][21][22] The definition of a canine universal donor is not unanimously agreed on among veterinary transfusion experts. The most restrictive definition of the universal donor would be a dog negative for DEAs 1, 3, 5, 7, and positive for DEA 4.…”

Section: Research-article2015mentioning

confidence: 99%

Prevalence of dog erythrocyte antigens 1, 4, and 7 in galgos (Spanish Greyhounds)

et al. 2015

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Galgos (Spanish Greyhounds), in common with other sighthounds, have higher hematocrits, hemoglobin concentrations, and red blood cell counts than other breeds. In addition to these hematological characteristics, the physical characteristics of these dogs (medium to large dogs with an easily accessible jugular vein and a good temperament) make galgos ideal blood donors. However, to date, there are only published reports concerning dog erythrocyte antigen (DEA) 1 in this breed. Information on DEAs 4 and 7 would be useful when recruiting blood donors to donation programs, as DEA 1 and 7-negative and DEA 4-positive dogs can be considered universal donors. Ethylenediamine tetra-acetic acid-anticoagulated jugular blood samples were collected from 205 galgos. Dogs were aged between 1 and 10 years, 102 were female (49.8%) and 103 male (50.2%), and all were living in South Madrid, Spain. All 205 blood samples were tested for DEA 1 by card agglutination, and 150 of these samples were tested for DEA 4 and DEA 7 by gel column agglutination using polyclonal anti-DEA antibodies. Of the 205 galgos blood samples typed, 112 out of 205 (54.6%) were positive for DEA 1. Of the 150 blood samples tested, all (150/150, 100%) were positive for DEA 4, and 12 out of 150 (8%) samples tested positive for DEA 7. Of these samples, 70 out of 150 (46.7%) were positive only for DEA 4. There was no relationship between blood types and sex. In addition to the hematological characteristics previously reported and the physical characteristics of these dogs, the relative prevalence of blood types DEA 1, 4, and 7 make galgos good candidates for blood donation in blood donor programs.

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“…There are no naturally occurring antibodies to DEA 1 in dogs. DEA 1 negative dogs exposed to DEA 1 positive RBCs will become “sensitized” within 9 days by production of anti-DEA 1 antibodies [12, 13]. Anti-DEA 1 antibodies have been reported to cause acute hemolytic transfusion reactions in previously sensitized DEA 1 negative dogs [14].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Dog Erythrocyte Antigens 1, 4, and 7 in Podenco Ibicenco (Ibizan Hounds) from Ibiza Island

Spada

Proverbio

Flórez³

et al. 2016

Veterinary Medicine International

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The aims of this study were to evaluate the prevalence of Dog Erythrocyte Antigens (DEA) 1, 4, and 7 in Ibizan hounds, to compare the results with the prevalence of DEA in Spanish greyhounds, and to determine the risk of sensitization following the first transfusion of blood not typed for DEA 1 and the probability of an acute hemolytic reaction following a second incompatible transfusion using untyped DEA 1 blood. DEA 1, 4, and 7 status was determined in 92 Ibizan hounds. Results were compared with the previously reported prevalence in Spanish greyhounds. The risks of sensitization and of a hemolytic transfusion reaction were determined amongst Ibizan hounds and between Ibizan hounds and Spanish greyhounds. The prevalence of DEA 1, 4, and 7 was 75%, 98.9%, and 25%, respectively. There was a significantly higher expression of DEA 1 and 7 in Ibizan hounds than in Spanish greyhounds. The probability of sensitization of a recipient dog to DEA 1 with transfusions amongst Ibizan hounds was 18.5% and between Ibizan hounds and Spanish greyhounds was 13.7%. The probability of an acute hemolytic reaction in each group was 3.5% and 1.9%, respectively. There is a higher prevalence of DEA 1 and 7 in Ibizan hounds than in other sighthounds.

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IN VITRO AND IN VIVO STUDIES OF THE BEHAVIOR OF CANINE ERYTHROCYTE‐ISOANTIBODY SYSTEMS*

Cited by 46 publications

References 16 publications

Transfusion practice in dogs and cats: an Internet‐based survey

Transfusion practice in dogs and cats: an Internet‐based survey

Prevalence of dog erythrocyte antigens 1, 4, and 7 in galgos (Spanish Greyhounds)

Prevalence of Dog Erythrocyte Antigens 1, 4, and 7 in Podenco Ibicenco (Ibizan Hounds) from Ibiza Island

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