In VitroAntimalarial Activity ofCoutarea latifloraandExostema caribaeumExtracts onPlasmodium falciparum

Malaria is currently a public health concern in many countries in the world due to various factors which are not yet under check. Drug discovery projects targeting malaria often resort to natural sources in the search for lead compounds. A survey of the literature has led to a summary of the major findings regarding plant-derived compounds from African flora, which have shown anti-malarial/antiplasmodial activities, tested by in vitro and in vivo assays. Considerations have been given to compounds with activities ranging from “very active” to “weakly active”, leading to >500 chemical structures, mainly alkaloids, terpenoids, flavonoids, coumarins, phenolics, polyacetylenes, xanthones, quinones, steroids and lignans. However, only the compounds that showed anti-malarial activity, from “very active” to “moderately active”, are discussed in this review.

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“…[86] and by Noster et al . [87] from Vernonia brachycalyx (Asteraceae) and Toddalia asiatica (Rutaceae), respectively. Cubukcu et al .…”

Section: Introductionmentioning

confidence: 99%

The potential of anti-malarial compounds derived from African medicinal plants, part II: a pharmacological evaluation of non-alkaloids and non-terpenoids

Ntie‐Kang

Onguéné

Lifongo

et al. 2014

Malar J

116

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“…Hypoglycemic and antimalarial 4-Phenylcoumarins Sanchez-Viesca (1969), Mata et al (1987Mata et al ( , 1988, Noster and Kraus (1990), Pinto et al (1997) and Slijepcevic et al (1997). Gnaphalium sp.…”

Section: Introductionmentioning

confidence: 99%

Acute toxicity and mutagenic activity of Mexican plants used in traditional medicine

Déciga-Campos

Rivero‐Cruz

Arriaga-Alba

et al. 2007

Journal of Ethnopharmacology

182

106

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“…Since 1980, large-scale in vitro and in vivo screenings of plants all over the world have been intensified and some of these have shown high antimalarial activities (Fandeur et al, 1985;Noster and Kraus, 1990;Koumaglo et al, 1991;Nkunya, 1992;Gessler et al, 1993).…”

Section: Introductionmentioning

confidence: 99%

Antimalarial activity in crude extracts of some Cameroonian medicinal plants

Bickii¹,

Tchouya²,

Tchouankeu³

et al. 2007

Afr. J. Trad. Compl. Alt. Med.

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Fifteen crude extracts from the stem bark and seeds of four medicinal plants, viz: Entandrophragma angolense, Picralima nitida, Schumanniophyton magnificum and Thomandersia hensii were tested in vitro for their antimalarial activity against the chloroquine-resistant Plasmodium falciparum W2 strain. The results showed that the extracts of these plants possessed some antimalarial activity, the methanol extract of Picralima nitida demonstrating the highest activity in vitro. Further isolation and identification of some active compounds from these plants will justify their common use in traditional medicine for the treatment of malaria or fever in Cameroon.

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In VitroAntimalarial Activity ofCoutarea latifloraandExostema caribaeumExtracts onPlasmodium falciparum

Cited by 32 publications

References 6 publications

The potential of anti-malarial compounds derived from African medicinal plants, part II: a pharmacological evaluation of non-alkaloids and non-terpenoids

The potential of anti-malarial compounds derived from African medicinal plants, part II: a pharmacological evaluation of non-alkaloids and non-terpenoids

Acute toxicity and mutagenic activity of Mexican plants used in traditional medicine

Antimalarial activity in crude extracts of some Cameroonian medicinal plants

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