In Vitro Antimicrobial Screening of Alkaloid Fractions from Strychnos potatorum

Mallikharjuna, P. B.; Seetharam, Y. N.

doi:10.1155/2009/535643

Cited by 16 publications

(11 citation statements)

References 13 publications

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“…The results of LC-MS/MS experiment indicated toon leaves fraction 5 contains N-[2-(D-Glucopyranosyloxy)ethyl]-2-hydroxy-N-[2hydroxy3 (octadecyloxy) propyl]butanamide and Brucine which may relate to the antifungal properties of the fraction 5 (Figure 3). Mallikharjuna and Seetharam (2009) reported that Brucine compound had antifungal activity against A. niger, A. fumigatus, C. albicans and M. gypseum fungi.…”

Section: Discussionmentioning

confidence: 99%

Identification of active compounds and antifungal activity of Toona sinensis leaves fractions against wood rot fungi

et al. 2018

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Elfirta RR, Falah S, Andrianto D, Lastini T. 2018. Identification of active compounds and antifungal activity of Toona sinensisleaves fractions against wood rot fungi. Biodiversitas 19: 1313-1318. Inhibitory activities of surian or toon (Toona sinensis) leavesfraction origin Sumedang, West Java, Indonesia against wood rot fungi (Ganoderma boninense IPBCC 10.658, Trametes versicolorInaCC F200, and Phanerochaete chrysosporium IPBCC 93.259) were studied. The samples were macerated using methanol andacetone. The results of brine shrimp lethality test (BSLT) showed that the methanol extract had the highest cytotoxicity of LC50 at 29.76μg/mL and inhibit the growth of G. boninense (27.78%), T. versicolor (79.26%) and P. chrysosporium (81.11%). The methanol extractwas then subsequently fractionated using n-hexane, diethyl ether, and ethyl acetate respectively. The diethyl ether fraction was found tohave the highest inhibitory activity against T. versicolor (46.30%) and P. chrysosporium (81.11%). This fraction was further separatedusing column chromatography and analyzed using thin layer chromatography (TLC), which gave six fractions. Antifungal test exhibitedthat fraction 5 had the highest antifungal properties against T. versicolor (74.07%) and P. chrysosporium (80.37%). Inhibition of P.chrysosporium resulted in abnormal growth of hyphae morphology as indicated by changes in its growth direction and excessive hyphaebranching. Additionally, the results of LC-MS/MS experiment indicated toon leaves fraction 5 which contains N-[2- (DGlucopyranosyloxy)ethyl]-2-hydroxy-N-[2hydroxy3 (octadecyloxy) propyl] butanamide dan Brucine compounds that were regarded as theantifungal compounds.

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Section: Discussionmentioning

confidence: 99%

Identification of active compounds and antifungal activity of Toona sinensis leaves fractions against wood rot fungi

et al. 2018

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“…Other Strychnos species have however been shown to display antimicrobial activity. For example, S. potatorum exhibited inhibitory action against Gram positive bacteria such as S. aureus, and Gram negative bacteria like Proteus vulgaris, S. typhimurium and Vibrio cholerae (Mallikharjuna and Seetharam, 2009 (Gnanavel et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial, antioxidant and anticancer activities of Strychnos lucida R. Br.

Sarmento¹,

Worachartcheewan²,

Pingaew³

et al. 2015

Afr. J. Trad. Compl. Alt. Med.

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Backgroud: Strychnos lucida R. Br. (Loganiaceae), a well-known indigenous medicine in Timor Leste, has been used for the treatment of ailments such as malaria, diarrhoea, fever, hypertension, cancer, diabetes mellitus and skin infections. Its pharmacological activity has never been reported. The aim of this study was to determine the biological activities of S. lucida, including antimicrobial, antioxidant and anticancer activities. Materials and methods:The stem, stem bark, twig and leaves of S. lucida were extracted by non-polar (hexane) and polar (ethyl acetate and methanol) solvents. Antimicrobial activity of the plant extracts against 29 microorganisms was evaluated using the agar dilution method and antioxidant properties were determined using DPPH and SOD assays. Anticancer activity was investigated against HepG2, HuCCA-1, A549 and MOLT-3 cell lines using the MTT and XTT assays. Results: It was found that the hexane and ethyl acetate extracts of S. lucida selectively inhibited the growth of Gram positive bacteria (Bacillus subtilis ATCC 6633, Bacillus cereus and Streptococcus pyogenes) with MICs range of 32-128 g/mL. Antioxidant activities, radical and superoxide scavenging properties, were observed for ethyl acetate and methanol extracts of S. lucida. Particularly, the ethyl acetate extracts selectively showed inhibitory activity against MOLT-3 cells. Notably, the plant extracts showed the relationship between antimicrobial, antioxidant and anticancer activities. Conclusion:The findings support the medicinal usage of S. lucida.

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“…It can be used for clarification of turbid water 81 . It also has metal binding properties 82 and antimicrobial properties 83 .…”

Section: Chemical Constituentsmentioning

confidence: 99%

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2015

IJPSR

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In the last few years, there has been an exponential growth in the field of herbal medicine and these drugs are gaining popularity both in developing and developed countries because of their natural origin and less side effects. The World Health Organization (WHO) has listed 21,000 plants, which are used for medicinal purposes around the world. Among these 2500 species are in India, out of which 150 species are used commercially on a fairly large scale. India is the largest producer of medicinal herbs and is called as botanical garden of the world. In this study, we intend to do a systematic search to identify the most potent antidiabetic herbs that are available in India. Relevant medical databases and websites were searched. To qualify for inclusion, the herbs should have excellent antidiabetic potential confirmed with biomarker (reduction in HbA1c) and the herbs should also possess limited adverse effects if at all any. Eligible studies must also meet the following criteria: published in English and peer-reviewed journals. We also used related keywords like diabetes mellitus, plant (herb), India, patient, glycemic control, clinical trial, RCT, natural or herbal medicine, Ayurvedic plants, hypoglycemic plants, and individual herb names from popular sources, as keywords or combination of them.

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In Vitro Antimicrobial Screening of Alkaloid Fractions from Strychnos potatorum

Cited by 16 publications

References 13 publications

Identification of active compounds and antifungal activity of Toona sinensis leaves fractions against wood rot fungi

Identification of active compounds and antifungal activity of Toona sinensis leaves fractions against wood rot fungi

Antimicrobial, antioxidant and anticancer activities of <i>Strychnos lucida</i> R. Br.

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