In vitro Antioxidant Activity and Phytochemical Study of Arbuscular mycorrhizal Fungi Induced Red Ginger (Zingiber. officinale var. rubrum)

Suharti, Netty; Hamidi, Dachriyanus; Lucida, Henny; Wahyuni, Fatma Sri; Putra, Purnawan Pontana

doi:10.2991/ahsr.k.211105.045

Cited by 1 publication

(1 citation statement)

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“…officinale). Rubrum) is one of the varieties that is cultivated and widely circulated in Indonesian society (Suharti et al, 2022). The red ginger plant that is often used by the community is the rhizome part because it has many uses including as a cooking spice, farms industry, perfume and cosmetics (Ivanović et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Antipyretic Drug Candidates Through Reverse Docking Techniques Used In Science Learning

Iksan,

Yusuf,

Fitriani B

et al. 2023

jppipa, pendidikan ipa, fisika, biologi, kimia

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Red ginger (Zingiber officinale var. Rubrum) is a commonly used rhizome known for its fragrant and spicy taste. It contains gingerol and shogaol compounds that have antipyretic effects by inhibiting prostaglandin formation and stimulating the production of interleukin-10, an endogenous antipyretic. This study aimed to evaluate the potential of gingerol and shogaol compounds as antipyretic drug candidates through reverse docking techniques targeting interleukin-10 (IL-10). Ten natural compounds from red ginger were predicted for their potential as antipyretic drugs and docked with the IL-10 receptor protein using various computer programs. The molecular docking results showed that (6)-shogaol had four amino acid bond residues that were the same as the ibuprofen control compound, indicating its potential as an antipyretic drug candidate. Furthermore, (6)-shogaol had the same binding affinity as the control compound and was safe for oral consumption based on pharmacokinetic and toxicity tests using Lipinski's Rule, Toxtree, and admet-T. These findings suggest that (6)-shogaol is a promising antipyretic drug candidate compared to other compounds. In conclusion, this study identified the potential of (6)-shogaol as an antipyretic drug candidate through reverse docking techniques targeting interleukin-10. Red ginger could provide a natural alternative for antipyretic drugs, and further research is recommended to explore the role of gingerol and shogaol compounds in targeting other proteins

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Section: Introductionmentioning

confidence: 99%