<i>In vitro</i>antioxidant and antiproliferative activities of nine<i>Salvia</i>species

Loizzo, Monica Rosa; Abouali, Morteza; Salehi, Peyman; Sonboli, Ali; Kanani, Mohammad Reza; Menichini, Francesco; Tundis, Rosa

doi:10.1080/14786419.2014.939086

Cited by 64 publications

(46 citation statements)

References 18 publications

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“…In addition to the classic antiherbivore roles of phenolics, the high levels of the compounds in the plant's leaves tissues may save them from photodamaging (Jassbi et al 2003). Rosmarinic acid derivatives and flavonoids are the most extensively studied compounds for this important biological effect (Matkowski et al 2008;Farhat et al 2013;Orhan et al 2013;Loizzo et al 2014). Weng and Wang isolated hispidulin 7-O-D-glucuronide (206), hispidulin-7-O-D-glucoside (207), 6-methoxy-luteolin-7-O-glucoside (208), b-sitosterol (177), 2 0 -hydroxy-5 0 -methoxybiochanin A (209) and coniferyl aldehyde (192) from S. plebeian (Fig.…”

Section: Antioxidant Activitymentioning

confidence: 99%

Bioactive phytochemicals from shoots and roots of Salvia species

et al. 2015

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The plants of the genus Salvia L. are important medicinal herbs of the Lamiaceae family and some of them such as S. officinalis (sage), S. miltiorrhiza (red sage, Danshen) and S. sclarea (clary sage) have been used as medicinal plants in the folk medicine of several countries. In this review, we discuss the reports that have examined Salvia species with the aim of isolation of pure compounds with different biological activities. The phytochemical analyses of various sage plants have reported 10 monoterpenoids (1-10), 1 sesquiterpenoid (11), 8 labdane (13-20), 15 ent-kaurane (21-35), 82 abietane, rearranged abietane and tanshinone (36-117), 3 icetexane (118-120), 43 clerodane (121-163), and 3 pimarane (164-166) diterpenoids with cytotoxic and antimicrobial, antiprotozoal, antioxidant, phytotoxic and insecticide effects. The other heavier terpenoids, including 3 sesterterpenes (167-169), 10 triterpenoids and b-sitosterol (170-180) have been introduced as minor bioactive compounds in the sage plants. Sahandinone (107), 6,7-dehydroroyleanone, 7-a-acetoxyroyleanone (40), and tanshinone like diterpenoids have been isolated from the roots' extracts of different Salvia species. On the other hand, several radical scavenger phenolic compounds like simple phenolics and caffeic acid derivatives (181-201) including rosmarinic acid, flavonoids (202-217) as well as phenolic diterpenoids, such as carnosol and carnosic acid have been isolated from the aerial parts of these plants. One pyrrole (218) and 3 antimicrobial oxylipins (219-221) are among the other less detected constituents in the members of Salvias. Furthermore, sages also synthesize antifungal, antileishmanial and antimalarial phytochemicals in their roots and shoots, which are reviewed in this paper. We also examine the allelopathic phenomena and the ecologically important phytochemicals identified in different parts of the sage plants. Finally, antifeedant and insecticide phenomena, which are due to the presence of volatile monoterpenes and clerodane diterpenes in these plants, are discussed. Considering the presence of diverse biologically active phytochemicals in the sage plants, they can be suggested as suitable candidates for the formulation of valuable natural medicines.

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Section: Antioxidant Activitymentioning

confidence: 99%

Bioactive phytochemicals from shoots and roots of Salvia species

et al. 2015

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“…Some of the species possess antimicrobial, antimalarial, anti-oxidant and antiproliferative activities (Loizzo et al 2014; Russo et al 2015; Jassbi et al 2016; Moridi Farimani & Abbas-Mohammadi 2016). Salvia apiana , commonly known as white sage, can be found scattered throughout southwestern North America, with the highest concentration in Southern California (Borek et al 2006).…”

Section: Introductionmentioning

confidence: 99%

Phytochemical and biological evaluation of Salvia apiana

Radhakrishnan

Hayes

Ross

2016

Natural Product Research

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Salvia apiana (white sage, Lamiaceae family) plant is native to southern California and parts of Mexico. Some Native American tribes local to this region consider S. apiana to be sacred and burn the leaves as incense for purification ceremonies. The plant has been used to treat sore throats, coughs, chest colds, upper respiratory infections and poison oak rashes. The aqueous ethanolic extract of S. apiana showed moderate CB1 activity (58.3% displacement). Chromatographic purification of the ethanolic extract on silica gel column led to isolation of nine compounds: rosmadial (I), carnosol (II), 16-hydroxycarnosol (III), sageone (IV), cirsimaritin (V), salvigenin (VI), oleanolic acid (VII), 3β,28-dihydroxy-urs-12-ene (VIII), and ursolic acid (IX). The structures of the isolated compounds were determined by their 1D, 2D NMR and MS spectral data. All the fractions and isolated compounds were tested for cannabinoid and opioid receptor binding.

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“…[1] Salvia species are ethnobotanically used for the treatment of several diseases such as colds, aches, infections, bronchitis, Alzheimer's disease (AD), and inflammation. [2,3] Moreover, this genus has economic importance because of its uses in pharmaceutical, food, and perfume industries. [4,5] For example, S. officinalis has wide uses as flavour and preservative in the preparation of food products and S. sclarea is used in wine production.…”

Section: Introductionmentioning

confidence: 99%

Comparative study of the essential oil composition of Salvia urmiensis and its enzyme inhibitory activities linked to diabetes mellitus and Alzheimer’s disease

Bahadori

Salehi

Sonboli

2017

International Journal of Food Properties

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The genus Salvia has economic importance due to its broad uses in traditional medicine, perfume, food, and pharmaceutical industries. In the present work, various extracts and essential oils of Salvia urmiensis Bunge., were screened for their inhibitory activity against acetylcholinesterase and butyrylcholinesterase, the enzymes linked to neurodegeneration, and against α-amylase and α-glucosidase (involved in diabetes mellitus; DM). Chemical compositions of the essential oils of leaves and flowers of the plant were also determined. The tested samples exhibited moderate to high anti-diabetic potential (IC 50 = 8-145 µg/mL) and moderate anticholinesterase activity (IC 50 = 44-892 µg/mL). Essential oil of leaves was rich in ester compounds such as ethyl linoleate (19%), methyl hexadecanoate (17%), and methyl linoleate (7.5%). The major compound of essential oil of flowers was 6,10,14-trimethyl-2-pentadecanone (55.7%). This is the first report on the enzyme inhibitory activity of S. urmiensis and also the chemical composition of its leaves and flowers in essential oils. The results indicated that S. urmiensis could be considered a valuable source for functional foods and pharmaceuticals.ARTICLE HISTORY

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In vitroantioxidant and antiproliferative activities of nineSalviaspecies

Cited by 64 publications

References 18 publications

Bioactive phytochemicals from shoots and roots of Salvia species

Bioactive phytochemicals from shoots and roots of Salvia species

Phytochemical and biological evaluation of Salvia apiana

Comparative study of the essential oil composition of Salvia urmiensis and its enzyme inhibitory activities linked to diabetes mellitus and Alzheimer’s disease

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