<i>In Vitro</i> Antioxidant Mechanism of Action of <i>Hibiscus Sabdariffa</i> in the Induction of Apoptosis against Breast Cancer

Sobantu, Mandisa Pamela; Okeleye, Benjamin I.; Okudoh, Vincent I.; Meyer, Mervin; Aboua, Yapo Guillaume

doi:10.1080/10496475.2022.2135661

Journal of Herbs, Spices & Medicinal Plants

2022

DOI: 10.1080/10496475.2022.2135661

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In Vitro Antioxidant Mechanism of Action of Hibiscus Sabdariffa in the Induction of Apoptosis against Breast Cancer

Mandisa Pamela Sobantu

Benjamin I. Okeleye

Vincent I. Okudoh

et al.

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Cited by 5 publications

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“…Medicinal plants have long been used globally for disease treatment, with many modern drugs derived from plant sources and their derivatives. Notably, Hibiscus sabdariffa has medicinal properties [74]. Natural plant extracts have demonstrated promising anti-tumor responses and improved pharmacological activity with reduced toxicity in advanced breast cancer patients.…”

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Chitosan-Based Nano Systems for Natural Antioxidants in Breast Cancer Therapy

et al. 2023

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Breast cancer is a major cause of death globally, accounting for around 13% of all deaths. Chemotherapy, the common treatment for cancer, can have side effects that lead to the production of reactive oxygen species (ROS) and an increase in oxidative stress in the body. Antioxidants are important for maintaining the health of cells and helping the immune system function properly. They play a crucial role in balancing the body’s internal environment. Using natural antioxidants is an alternative to mitigate the harmful effects of oxidative stress. However, around 80% of natural antioxidants have limited effectiveness when taken orally because they do not dissolve well in water or other solvents. This poor solubility affects their ability to be absorbed by the body and limits their bioavailability. One strategy that has been considered is to increase their water solubility to increase their oral bioavailability. Chitosan-based nanoparticle (CSNP) systems have been extensively explored due to their reliability and simpler synthesis routes. This review focuses on the various methods of chitosan-based nanoformulation for developing effective oral dosage forms for natural antioxidants based on the pharmacokinetics and pharmacodynamics properties. Chitosan (CS) could be a model, because of its wide use in polymeric NPs research, thus providing a better understanding of the role of vehicles that carry natural antioxidants in maintaining the stability and enhancing the performance of cancer drugs.

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Chitosan-Based Nano Systems for Natural Antioxidants in Breast Cancer Therapy

et al. 2023

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Anticancer properties of Roselle (Hibiscus sabdariffa L), review article

Ahmed,

Khalid

2024

Vegetos

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Production of polycaprolactone foams incorporating Hibiscus sabdariffa extract

Trucillo,

Nebbioso,

Ferrari

et al. 2024

European Polymer Journal

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In Vitro Antioxidant Mechanism of Action of Hibiscus Sabdariffa in the Induction of Apoptosis against Breast Cancer

Cited by 5 publications

References 23 publications

Chitosan-Based Nano Systems for Natural Antioxidants in Breast Cancer Therapy

Chitosan-Based Nano Systems for Natural Antioxidants in Breast Cancer Therapy

Anticancer properties of Roselle (Hibiscus sabdariffa L), review article

Production of polycaprolactone foams incorporating Hibiscus sabdariffa extract

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