<i>In Vitro</i>Antiparasitic Activity of Plant Extracts from Panama

Barrio, Alicia; Grueiro, M. M. Martinez; Montero, David; Nogal, Juan José; Escario, José Antonio; Muelas, Susana; Fernàndez, Cèsar; Vega, Celeste; Rolón, Míriam; Fernandez, Angela; Solı́s, Pablo; Gupta, Mahabir P.

doi:10.1080/13880200490511945

Cited by 15 publications

(6 citation statements)

References 17 publications

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“…Previous pharmacological studies have revealed that Bixa orellana extracts possess antiprotozoal, anthelmintic and platelet antiaggregant activity (Villar et al, 1997;Barrio et al, 2004). Root extracts have been reported to have spasmolytic activity (Mans et al, 2004).…”

Section: Introductionmentioning

confidence: 98%

Preliminary pharmacological screening of Bixa orellana L. leaves

Shilpi

Taufiq-ur-Rahman

Uddin

et al. 2006

Journal of Ethnopharmacology

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Section: Introductionmentioning

confidence: 98%

Preliminary pharmacological screening of Bixa orellana L. leaves

Shilpi

Taufiq-ur-Rahman

Uddin

et al. 2006

Journal of Ethnopharmacology

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“…Fleischer et al demonstrated the antimicrobial activity of B. orellana leaf and seed extracts against a range of Gram-positive and Gram-negative bacteria and fungi [15]. Moreover, some pharmacological studies have revealed that B. orellana extracts possess an antiprotozoal and anthelmintic effect [16]. Due to their broad antioxidant and antibacterial activities, polar extracts from B. orellana leaves and seeds have been recently proposed as alternative natural preservatives in food matrices [17].…”

mentioning

confidence: 99%

Secondary Metabolite Profile, Antioxidant Capacity, and Mosquito Repellent Activity of Bixa orellana from Brazilian Amazon Region

Giorgi

Marinis²,

Granelli³

et al. 2013

Journal of Chemistry

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The Brazilian flora was widely used as source of food and natural remedies to treat various diseases.Bixa orellanaL. (Bixaceae), also known as annatto, urucù, or achiote, is a symbol for the Amazonian tribes that traditionally use its seeds as coloured ink to paint their bodies for religious ceremonies. The aim of this study was to investigate the volatile organic compounds (VOCs) profile ofB. orellanafresh fruits (in vivosampled), dried seeds, wood, bark, and leaves analyzed with Headspace solid-phase microextraction coupled with gas chromatography and mass spectrometry. A screening on phenolic content (the Folin-Ciocalteu assay) and antiradical activity (DPPH assay) of seeds was also conducted. In addition, the repellent properties of seed extracts againstAedes aegyptiL. were investigated. Volatile compounds detected inB. orellanasamples consisted mainly of sesquiterpenes, monoterpenes, and arenes:α-humulene is the major volatile compound present in seed extracts followed by D-germacrene,γ-elemene, and caryophyllene.B. orellanaproved to be a good source of antioxidants. Preliminary data on repellency againstA. aegyptiof three different dried seed extracts (hexane, ethanol, and ethanol/water) indicated a significant skin protection activity. A protection of 90% and 73% for hexane and ethanol/water extracts was recorded.

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“…orellana L. extracts have antiprotozoal, anthelmintic, platelet antiaggregant, [14,15] and anticlastogenic activity. [16] The root extracts have spasmolytic activity, whereas leaf and branch extracts were effective at neutralizing the effects of snake venoms.…”

Section: Discussionmentioning

confidence: 99%

Hepatoprotective activity of aqueous and ethanolic Bixa orellana L. leaf extracts against carbon tetrachloride-induced hepatotoxicity

Lopez¹,

Sumalapao²,

Villarante³

2017

Natl J Physiol Pharm Pharmacol

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Background: There is an increasing incidence of liver failure and lack of effective drugs for liver diseases. Aim and Objective: This study identified the phytochemicals present in aqueous and ethanolic Bixa orellana L. leaf extracts and investigated the hepatoprotective activity against carbon tetrachloride (CCl 4 )-induced hepatotoxicity in mice. Specifically, the study compared serum levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) and examined liver tissues histopathology. Materials and Methods: Aqueous and ethanolic B. orellana L. leaf extracts were prepared and screened for phytochemical contents. An oral dose of 500 mg/kg body weight was identified from toxicity test and administered to albino mice. Microscopic examination of the liver tissues assessed the extent of hepatic injury. Serum AST and ALT levels were compared using one-way analysis of variance with Bonferroni post hoc analysis at 5% level of significance using Stata/SE V12.0 software. Results: B. orellana L. leaves contained alkaloids, anthraquinones, sugars, and tannins. Aqueous and ethanolic leaf extracts of B. orellana L. did not show any toxicity up to 2000 mg/kg body weight oral dose in mice. Pre-treatment for 7 days before CCl 4 administration significantly prevented elevation of serum AST and ALT levels with histopathologic findings showing a protective effect on the hepatocytes. Conclusion: B. orellana L. leaves have potent hepatoprotective activity against oxidative damage.

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In VitroAntiparasitic Activity of Plant Extracts from Panama

Cited by 15 publications

References 17 publications

Preliminary pharmacological screening of Bixa orellana L. leaves

Preliminary pharmacological screening of Bixa orellana L. leaves

Secondary Metabolite Profile, Antioxidant Capacity, and Mosquito Repellent Activity of Bixa orellana from Brazilian Amazon Region

Hepatoprotective activity of aqueous and ethanolic Bixa orellana L. leaf extracts against carbon tetrachloride-induced hepatotoxicity

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