2008
DOI: 10.1002/tox.20347
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In vitro assessment of clastogenicity of mobile‐phone radiation (835 MHz) using the alkaline comet assay and chromosomal aberration test

Abstract: Recently we demonstrated that 835-MHz radiofrequency radiation electromagnetic fields (RF-EMF) neither affected the reverse mutation frequency nor accelerated DNA degradation in vitro. Here, two kinds of cytogenetic endpoints were further investigated on mammalian cells exposed to 835-MHz RF-EMF (the most widely used communication frequency band in Korean CDMA mobile phone networks) alone and in combination with model clastogens: in vitro alkaline comet assay and in vitro chromosome aberration (CA) test. No di… Show more

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Cited by 35 publications
(11 citation statements)
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“…However, case-control studies, cell culture studies and animal studies regarding the effect of cell phone systems have caused public concern. There are also many results supporting their hazardous effects as well as negative findings in the literature [9][10][11][12]. Studies about the health effects of RF can be grouped as experimental cell culture studies, animal studies and studies of observations of the effects of RF in life by a number of methods, such as geographical correlation studies, studies in individuals from different occupations exposed to RF energy and studies of mobile phone users [2].…”
Section: Discussionmentioning
confidence: 97%
“…However, case-control studies, cell culture studies and animal studies regarding the effect of cell phone systems have caused public concern. There are also many results supporting their hazardous effects as well as negative findings in the literature [9][10][11][12]. Studies about the health effects of RF can be grouped as experimental cell culture studies, animal studies and studies of observations of the effects of RF in life by a number of methods, such as geographical correlation studies, studies in individuals from different occupations exposed to RF energy and studies of mobile phone users [2].…”
Section: Discussionmentioning
confidence: 97%
“…There have been numerous reports on the possible direct and indirect inductions of DNA damage, chromosome alteration and MN by RF radiation [Tice et al, 2002;Mashevich et al, 2003;Kim et al, 2008;Luukkonen et al, 2009]. However, most of these studies did not make any definite statements about genotoxic and co-genotoxic effects of RF-EMF, and stated that further research is needed [Li et al, 2001;Meltz, 2003;Verschaeve et al, 2006].…”
Section: Discussionmentioning
confidence: 91%
“…However, despite the large number of in vitro investigations to assess whether RF exposure induces adverse biological effects, few studies have been carried out on these cells, addressing genotoxicity [ Speit et al, 2007;Kim et al, 2008;Ballardin et al, 2011], oxidative stress [Marjanovic et al, 2015], cell viability, and growth [Pavicic and Trosic, 2008].…”
Section: Discussionmentioning
confidence: 99%