In‐vitro biocompatibility, bioactivity and photoluminescence properties of Eu3+/Sr2+ dual‐doped nano‐hydroxyapatite for biomedical applications

Sundarabharathi, Lakshmanaperumal; Parangusan, Hemalatha; Ponnamma, Deepalekshmi; Al-Maadeed, Somaya; Chinnaswamy, Mahendran

doi:10.1002/jbm.b.34023

Cited by 18 publications

(7 citation statements)

References 57 publications

(114 reference statements)

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“…This is attributed to the presence of particle agglomerates and the possible kinetic coagulation occurring during the analysis. 39 This is in good agreement with both agglomeration and uneven particle sizes visualized in the TEM micrographs. In other words, the particle sizes obtained from the XRD and TEM studies are comparable, however the DLS method provide agglomerated particle information and is not comparable with the other data.…”

Section: Morphological Characterizationsupporting

confidence: 84%

“…Both Sr 2+ and Ce 3+ dopant atoms occupy these Ca-I and Ca-II sites; however, better accommodated in Ca-(II) site due to its higher energy. 39 A charge imbalance and variation in ionic radius are provoked in the crystallographic axes on co-substitution of Sr 2+ and Ce 3+ for Ca 2+ . At higher dopant ion concentrations, the Ca(II) site also gets occupied, which is aligned in columns parallel to c-axis.…”

Section: Structural Analysis Of the Nanoparticlesmentioning

confidence: 99%

“…The synthesis of HA nanoparticles was realized by different methods such as microwave assisted, hydrothermal, sol-gel, microemulsion, freezing, solvothermal, and highgravity precipitation methods. [33][34][35][36] Among these, the sol-gel assisted precipitation method extends eminent advantages including high product purity, homogeneous compositions, and low synthesis temperature [37][38][39] and is adopted in this work. The main aim here is to synthesize Ce 3+ /Sr 2+ cosubstituted HA nanoparticles using a chelating agent ethylene diamine tetra acetic acid (EDTA).…”

Section: Introductionmentioning

confidence: 99%

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Investigation of antimicrobial properties and in‐vitro bioactivity of Ce³⁺‐Sr²⁺dual‐substituted nano hydroxyapatites

et al. 2018

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Dual doped calcium apatite has been widely focused as it enhances the osteoconductive property for the possible applications in orthopedic and dental implants. In this work, we investigate the antimicrobial and bioactive properties of cerium/ strontium (Ce 3+ /Sr 2+ ) co-substituted hydroxyapatite (HA) nanoparticles synthesized by sol-gel assisted precipitation method. The structure, morphology, functional groups, photoluminescence, and thermal stability of the developed systems are examined. The comparative studies performed among the pure HA, Sr 2+ , and Ce 3+ -substituted HA nanoparticles illustrate higher antibacterial activity with lowered apatite-forming ability and biocompatibility for the Ce 3+ -substituted HA. However, the Ce 3+ /Sr 2+ co-substituted HA exhibits better biocompatibility, apatite-forming ability, and good antimicrobial properties. Sr 2+ ion inclusion leads to better biological properties and compromise the cytotoxic nature of the Ce 3+ -HA.In addition, the Ce 3+ /Sr 2+ -HA nanoparticles prevent thermal decomposition up to 700°C, pointing also toward the possibility of this co-substituted HA in bone implant applications. K E Y W O R D Sbioactivity, biocompatibility, hydroxyapatite, live cell imaging, Sol-gel

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Section: Morphological Characterizationsupporting

confidence: 84%

Section: Structural Analysis Of the Nanoparticlesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Investigation of antimicrobial properties and in‐vitro bioactivity of Ce³⁺‐Sr²⁺dual‐substituted nano hydroxyapatites

et al. 2018

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“…However, the size, morphology, and crystallinity of HAp particles greatly alter the functional performance of these biomaterials in biomedical applications mostly in bone regeneration, reconstruction and replacement [19]. [6] https://www.nepjol.info/index.php/JNCS Incorporation of dual bioactive ions into nano-HAp particles produces biomaterials with improved bioactivities and osteo-conduction applicable for line cell imaging [20]. Nano-sized HAp better improves cytophilicity and possesses greater bioactivities, biosorption and proliferation to bone marrow optimizing biological functionality if compared to conventional micro/macro-sized HAp [19,21,22].…”

Section: Introductionmentioning

confidence: 99%

An Overview of Synthesis Based Biomedical Applications of Hydroxyapatite Nanomaterials

Bhandari

Bista

Gautam

et al. 2021

J. Nepal Chem. Soc.

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Hydroxyapatite (HAp) is the mineral phase of animal bones embedded in a collagen-containing organic matrix. It is a naturally optimized material for the physical support of the bones. Synthetic Hydroxyapatite based biomaterials, hence, find wide applications in orthopedics, dentistry, and tissue engineering due to their biocompatibility, bioactivity, osteoconductivity, and similar chemical composition to that of HAp present in animal bones. Different physicochemical synthetic methods and natural biogenic sources have been reported for the synthesis of nano-hydroxyapatite. However, particle size, aspect ratio, and the distribution of HAp in biomaterials have significant effects to use as bone substitutes and implants. This paper has summarized some synthetic methods of preparing nano-HAp from different biogenic approaches. Further, it focuses on some facile synthetic routes of preparing nano-HAp with controlled particle size with higher crystallinity and native bone architectures. This review article aims to correlate some simplistic and cost-effective biosynthetic approaches of nano-HAp, their size-dependent properties characterization, and biomedical applications.

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“…The further improvement of magnetic characteristics was accomplished by co-doping HAp:Gd 3+ with Fe, due to which the obtained nanoparticles showed a high potential for use as agents in positron emission tomography (PET) and single-photon emission computed tomography (SPECT) 35,36 . Lumino-magnetic, as well as lumino-antimicrobial properties have been obtained by co-doping europium with dysprosium 37 or strontium 38 in HAp nanoparticles.…”

mentioning

confidence: 99%

Rare-earth (Gd3+,Yb3+/Tm3+, Eu3+) co-doped hydroxyapatite as magnetic, up-conversion and down-conversion materials for multimodal imaging

Ignjatović

Mančić

Vuković

et al. 2019

Sci Rep

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Taking advantage of the flexibility of the apatite structure, nano-and micro-particles of hydroxyapatite (HAp) were doped with different combinations of rare earth ions (RE 3+ = Gd, eu, Yb, tm) to achieve a synergy among their magnetic and optical properties and to enable their application in preventive medicine, particularly diagnostics based on multimodal imaging. All powders were synthesized through hydrothermal processing at t ≤ 200 °C. An X-ray powder diffraction analysis showed that all powders crystallized in P6 3 /m space group of the hexagonal crystal structure. The refined unit-cell parameters reflected a decrease in the unit cell volume as a result of the partial substitution of Ca 2+ with smaller Re 3+ ions at both cation positions. the ftiR analysis additionally suggested that a synergy may exist solely in the triply doped system, where the lattice symmetry and vibration modes become more coherent than in the singly or doubly doped systems. HAp:Re 3+ optical characterization revealed a change in the energy band gap and the appearance of a weak blue luminescence (λ ex = 370 nm) due to an increased concentration of defects. the "up"-and the "down"-conversion spectra of HAp:Gd/Yb/tm and HAp:Gd/eu powders showed characteristic transitions of tm 3+ and eu 3+ , respectively. furthermore, in contrast to diamagnetic HAp, all HAp:Re 3+ powders exhibited paramagnetic behavior. cell viability tests of HAp:Gd/Yb/tm and HAp:Gd/eu powders in human dental pulp stem cell cultures indicated their good biocompatibility.

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In‐vitro biocompatibility, bioactivity and photoluminescence properties of Eu³⁺/Sr²⁺ dual‐doped nano‐hydroxyapatite for biomedical applications

Cited by 18 publications

References 57 publications

Investigation of antimicrobial properties and in‐vitro bioactivity of Ce³⁺‐Sr²⁺dual‐substituted nano hydroxyapatites

Investigation of antimicrobial properties and in‐vitro bioactivity of Ce³⁺‐Sr²⁺dual‐substituted nano hydroxyapatites

An Overview of Synthesis Based Biomedical Applications of Hydroxyapatite Nanomaterials

Rare-earth (Gd3+,Yb3+/Tm3+, Eu3+) co-doped hydroxyapatite as magnetic, up-conversion and down-conversion materials for multimodal imaging

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In‐vitro biocompatibility, bioactivity and photoluminescence properties of Eu3+/Sr2+ dual‐doped nano‐hydroxyapatite for biomedical applications

Cited by 18 publications

References 57 publications

Investigation of antimicrobial properties and in‐vitro bioactivity of Ce3+‐Sr2+dual‐substituted nano hydroxyapatites

Investigation of antimicrobial properties and in‐vitro bioactivity of Ce3+‐Sr2+dual‐substituted nano hydroxyapatites

An Overview of Synthesis Based Biomedical Applications of Hydroxyapatite Nanomaterials

Rare-earth (Gd3+,Yb3+/Tm3+, Eu3+) co-doped hydroxyapatite as magnetic, up-conversion and down-conversion materials for multimodal imaging

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In‐vitro biocompatibility, bioactivity and photoluminescence properties of Eu³⁺/Sr²⁺ dual‐doped nano‐hydroxyapatite for biomedical applications

Investigation of antimicrobial properties and in‐vitro bioactivity of Ce³⁺‐Sr²⁺dual‐substituted nano hydroxyapatites

Investigation of antimicrobial properties and in‐vitro bioactivity of Ce³⁺‐Sr²⁺dual‐substituted nano hydroxyapatites