<i>In vitro</i> cytogenetic activity of 3-amino-4-[4-(dimethylamino)phenyl]-4,5-dihydro-1,2,5-thiadiazole 1,1-dioxide

Şekeroğlu, Zülal Atlı; Ertürk, Aliye Gediz; Yedier, Seval Kontaş; Şekeroğlu, Vedat

doi:10.1080/01480545.2019.1677703

Cited by 6 publications

(5 citation statements)

References 19 publications

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“…While monotherapy is still very common for many cancer types, the therapy is not selective as they can destroy both healthy and cancerous cells. Therefore, combination therapy, in which two or more agents can be used together, is considered an optimal approach for cancer treatment 23 . There are some studies investigating the potential effects of CeONPs on some cancer cells when used together with different chemotherapeutic drugs.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, combination therapy, in which two or more agents can be used together, is considered an optimal approach for cancer treatment. 23 There are some studies investigating the potential effects of CeONPs on some cancer cells when used together with different chemotherapeutic drugs. CeONPs covered with the anticancer drug neogambogic acid could prevent tumor progression and sensitize tumor cells to radiation by causing G2/M arrest, inducing autophagy, and increasing the rate of cell death in MCF-7 cells.…”

Section: Adhesion Assaymentioning

confidence: 99%

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Cerium oxide nanoparticles exert antitumor effects and enhance paclitaxel toxicity and activity against breast cancer cells

Şekeroğlu

Aydın

et al. 2022

J Biomed Mater Res

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Cerium oxide nanoparticles (CeONPs) displayed cytotoxic properties against some cancer cells. However, there is very limited data about the possible antitumoral potential of them in breast cancer cells when used alone and/or together with a chemotherapeutic drug. We investigated the effects of CeONPs alone or in combination with paclitaxel (PAC) on healthy or carcinoma breast cells. After human breast cancer cells (MCF-7) treated with CeONPs alone or together with PAC for 24, 48, and 72 h, the effects of CeONPs on cell viability, apoptosis, migration, and adhesion were investigated. All cell viability and IC50 values of CeONPs and PAC treatments in healthy breast cells (HTERT-HME1) were higher than MCF-7 cells. They showed higher cytotoxicity against MCF-7 cells. CeONPs (10, 20, and 30 mM) and/or abraxane (AB) (2 μM) significantly decreased cell viability values in MCF-7 cells. All CeONPs concentrations increased the number of apoptotic MCF-7 cells. CeONPs (20 and 30 mM) alone or in combination with AB for 72 h treatment also significantly increased the apoptosis in compared to AB alone. CeONPs and/or AB can significantly inhibit the migratory ability of breast cancer cells. The migration rates in co-treated groups with CeONPs and AB were lower than CeONPs treatments.Higher concentrations of CeONPs alone or together with AB inhibited cell adhesion.Our results showed CeONPs can increase cytotoxicity and apoptosis and decrease cell migration and cell adhesion when used alone or together with AB. Therefore, combination of chemotherapeutics with CeONPs may provide a good strategy against cancer.

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Section: Discussionmentioning

confidence: 99%

Section: Adhesion Assaymentioning

confidence: 99%

Cerium oxide nanoparticles exert antitumor effects and enhance paclitaxel toxicity and activity against breast cancer cells

Şekeroğlu

Aydın

et al. 2022

J Biomed Mater Res

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“…The development of novel anticancer drugs and strategies to improve treatment is critical. 22 Combination therapy is defined as 2 or more therapeutic agents were administered together, which is considered as an optimal approach to cancer therapy as multiple pathways may be targeted. Although, the monotherapy approach is still very common for many different types of cancer, it is generally considered less effective than using a combination.…”

Section: Discussionmentioning

confidence: 99%

Effects of Reverse Transcriptase Inhibitors on Proliferation, Apoptosis, and Migration in Breast Carcinoma Cells

Şekeroğlu

Küçük

2020

Int J Toxicol

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High telomerase activity in human breast cancer is associated with aggressive tumors resulting in decreased survival. Recent studies have shown that telomerase inhibitors may display anticancer properties in some human cancer cell lines. In the present study, we examined the effects of 4 reverse transcriptase inhibitors (RTIs), used for the treatment of HIV; Abacavir (AC), Lamivudine (LV), Stavudine (SV), and Tenofovir (TF) on proliferation, apoptosis, and migration in the normal human mammary epithelial cell line, hTERT-HME1, and the human breast cancer cell line, MCF-7. Cells were treated with AC, LV, SV, or TF alone or in combination with paclitaxel (PAC), a known drug used to treat breast cancer. Conduct of the thiazolyl blue tetrazolium bromide assay demonstrated that AC, SV, and TF had stronger cytotoxic effects on MCF-7 cells than in hTERT-HME1 cells. The combined treatment of RTIs and PAC caused high rates of cell death in MCF-7 and low rates of cell death in HTERT-HME1 by apoptosis. The percentages of apoptotic cells in the treatment of AC and SV in combination with PAC for 48 and 72 hours were higher than PAC. Significantly increased apoptosis and decreased migration levels were found in MCF-7 cells treated with AC and co-treatment of AC+PAC or SV+PAC than HME1 cells. These treatments can also prevent migration capacity more than PAC. Therefore, a combination strategy based on telomerase inhibitors such as AC or SV and anticancer drugs may be more effective in the treatment of certain breast cancers.

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“…Sulfonamides are the important class of drugs found to have antibacterial, [11] insulin‐releasing, [12] carbonic anhydrase inhibitory, [13] anti‐inflammatory, [14] antidiabetic [15] and antitumor activities [16] . Electron‐rich heteroaromatic substrates such as isoxazolone, pyran, pyridine, imidazole, thiophene, thiazole, and benzothiazole are considered as an indisputable, essential feature and part of pharmacophores [17,18] …”

Section: Introductionmentioning

confidence: 99%

“…[7] In addition to their biological activity evaluation, these are found to have applications in OLEDs, NLO, DSSCs, metal sensing, etc, due to their favourable photophysical characteristics such as solvatochromic absorption and emission, solid state emission, high quantum yield, large stokes shift, etc. [8][9][10] Sulfonamides are the important class of drugs found to have antibacterial, [11] insulin-releasing, [12] carbonic anhydrase inhibitory, [13] anti-inflammatory, [14] antidiabetic [15] and antitumor activities. [16] Electron-rich heteroaromatic substrates such as isoxazolone, pyran, pyridine, imidazole, thiophene, thiazole, and benzothiazole are considered as an indisputable, essential feature and part of pharmacophores.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Novel Sulfonamide Incorporated Azo Compounds as a PotentSolvatochromic and Antimycobacterial Agents

et al. 2022

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In search of potent solvatochromic and biological agents, here we reported the synthesis of four azo dyes (S1-S4) owing sulfonamide functionality by diazo coupling reaction and their spectroscopic properties were investigated through UV, DRS, IR, NMR and mass spectrometry. Quantum chemical parameters of the synthesised colourants were assessed through DFT studies. The solvatochromic behaviour of sulfonamide incorporated azo compounds was investigated in ten different solvents owing different polarity and proticity and they exhibited remarkable positive solvatochromic behaviour and they exhibited λ max in the range 395-464 nm. Antituberculosis efficacy was evaluated using MABA assay against M. Tuberculosis,among the synthesised colourants compound S3furnished good activity viz MIC = 3.85 μM and the remaining compounds showed moderate activity with the MIC values in the range 14.84-32.38 μM.

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In vitro cytogenetic activity of 3-amino-4-[4-(dimethylamino)phenyl]-4,5-dihydro-1,2,5-thiadiazole 1,1-dioxide

Cited by 6 publications

References 19 publications

Cerium oxide nanoparticles exert antitumor effects and enhance paclitaxel toxicity and activity against breast cancer cells

Cerium oxide nanoparticles exert antitumor effects and enhance paclitaxel toxicity and activity against breast cancer cells

Effects of Reverse Transcriptase Inhibitors on Proliferation, Apoptosis, and Migration in Breast Carcinoma Cells

Synthesis of Novel Sulfonamide Incorporated Azo Compounds as a PotentSolvatochromic and Antimycobacterial Agents

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