Synthesis of Novel Sulfonamide Incorporated Azo Compounds as a PotentSolvatochromic and Antimycobacterial Agents

Abstract

In search of potent solvatochromic and biological agents, here we reported the synthesis of four azo dyes (S1-S4) owing sulfonamide functionality by diazo coupling reaction and their spectroscopic properties were investigated through UV, DRS, IR, NMR and mass spectrometry. Quantum chemical parameters of the synthesised colourants were assessed through DFT studies. The solvatochromic behaviour of sulfonamide incorporated azo compounds was investigated in ten different solvents owing different polarity and proticity and they exhibited remarkable positive solvatochromic behaviour and they exhibited λ max in the range 395-464 nm. Antituberculosis efficacy was evaluated using MABA assay against M. Tuberculosis,among the synthesised colourants compound S3furnished good activity viz MIC = 3.85 μM and the remaining compounds showed moderate activity with the MIC values in the range 14.84-32.38 μM.

Coumarin‐Benzothiazole Hydrazone for Probing of Latent Fingerprints and Anti‐Counterfeiting Applications

“…Figure 7b displays the change in PL intensity of CHFT solutionto the increase in % ratio of water fraction. From the obtained results, it was proven that the synthesized CHFT is an excellent AIE material [29–31] …”

“…From the obtained results, it was proven that the synthesized CHFT is an excellent AIE material. [29][30][31]…”

Benzothiazole‐Hydrazone Chromophores: Synthesis, Solvatochromism, Computational and Antimycobacterial Activity Studies

“…Details of the experimental procedures, characterization data for the synthesized compounds and IR, 1 HNMR, 13 CNMR and Mass spectra of synthesised compounds and Additional references cited within the Supporting nformation. [29][30][31][32][33][34]…”

Efficient and environmentally-friendly access to 4,5-unsaturated sulfonamides through ligand-free copper-BF3-catalyzed three-component alkene carbo-sulfonamidation

“…7 Some sulfonamides have been employed as chemical sensors for toxic metal ions and anions such as fluoride, CN − , P 2 O 7 4− , and N 3 − and as potent solvatochromic dyes. 8,9 In addition, alkene-bearing sulfonamides are often used as intermediates for the synthesis of natural products. 10 Polymeric materials with sulfonamide functionality have gained interest over the last decade, and many sulfonamide-bearing polymers have been synthesized.…”