In vitroefficiency of vancomycin containing experimental drug delivery systems

Abstract

Biofilm-forming Staphylococcus epidermidis strains are common cause of the periprosthetic infection. The treatment of the periprosthetic infection is very problematic, so the prevention of these infections by an antibiotic containing prothesis could be an option for prevention.The purpose of the present study was to examine the in vitro effects of drug delivery systems (DDSs), namely Wax 1 and Wax 2 with different vancomycin content: 0.5, 1, 2 and 4 mg. In order to control the antibacterial activity of DDSs killing curve study was performed and in order to determine the antibiotic release and the antibiotic peak concentration from the DDSs biological assay was carried out.The time kill curve studies showed, that both DDSs with all vancomycin concentration decreased significantly the bacterial counts, however, Wax 2 with 4 mg vancomycin significantly decreased the bacterial count than all the other groups.The vancomycin release was the best with the highest peak concentration from DDSs with 4 mg vancomycin contain; it was significantly better than in the other groups, however, no significant difference was observed between Wax 1 and Wax 2 in this respect.These findings suggest that Wax 2 with 4 mg vancomycin content could be a potential agent for clinical use.

Lignocellulosic membrane grafted with 4-vinylpiridine using radiation chemistry: antimicrobial activity of loaded vancomycin

“…Firstly, this article presents the synthesis of 4VP-graft (-g-4VP) functionalized lignocellulosic membranes to create a pH-responsive material, followed by the load and release of the antimicrobial agent in the resulting material. The drug vancomycin, a glycopeptide, was selected due to its activity against most Gram-positive microorganisms (Szász et al 2013;Fusco et al 2018), including several pathogen bacteria for human beings, which cause severe or fatal infections. After, the new pH-sensitive lignocellulosic membranes were characterized by FTIR-ATR, 13 C-NMR, XPS analysis, and TGA.…”

Polypropylene Graft Poly(methyl methacrylate) Graft Poly(N-vinylimidazole) as a Smart Material for pH-Controlled Drug Delivery

“…In summary, this work presents grafting polymerization of MMA and NVI onto PP with the subsequent loading and release of vancomycin [ 21 ], where the pH-responsiveness of NVI chains [ 22 ] was studied as well as other physicochemical properties, such as swelling and contact angle.…”

Polypropylene Graft Poly(Methyl Methacrylate) Graft Poly(N-Vinylimidazole) as a Smart Material for pH-Controlled Drug Delivery

“…In summary, this work presents grafting polymerization of MMA and NVI onto PP with the subsequent vancomycin loading [21], where the pH-responsiveness of NVI chains [22] was studied as well as other physicochemical properties such as swelling, contact angle, and vancomycin release.…”