<i>In Vitro</i> Evaluation of Aerosol Delivery by Hand-Held Mesh Nebulizers in an Adult Spontaneous Breathing Lung Model

Tseng, Hui-Yun; Lin, Hui-Ling; Chiang, Han-Sun

doi:10.1089/jamp.2021.0010

Cited by 5 publications

(3 citation statements)

References 34 publications

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“…( Suk et al, 2011a ). The dose of NAC to be deposited during the experiments, was estimated by considering the clinical dose (3–5 ml of 20% ( w / v ) NAC solution given 3–4 times/day), the tracheobronchial surface area (2471 cm 2 ) ( Jachak et al, 2012 ), and the deposition factor (percentage of the applied dose that reaches the respiratory tract) (10%) ( Carvalho et al, 2011 ; Tseng et al, 2022 ). Based on this approach, 120 μg/cm 2 NAC was calculated to be deposited onto the tracheobronchial surface per day during clinical use.…”

Section: Methodsmentioning

confidence: 99%

Impact of mucus modulation by N-acetylcysteine on nanoparticle toxicity

Meziu,

Shehu,

Koch

et al. 2023

International Journal of Pharmaceutics: X

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Section: Methodsmentioning

confidence: 99%

Impact of mucus modulation by N-acetylcysteine on nanoparticle toxicity

Meziu,

Shehu,

Koch

et al. 2023

International Journal of Pharmaceutics: X

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“…Исследование эффективности меш-небулайзеров VELOX (PARI) у взрослых продемонстрировало быстрое купирование симптомов астмы и сокращение длительности госпитализации более чем на треть в сравнении с другими видами небулайзеров [49].…”

Section: продолжительность ингаляцииunclassified

Place of nebulizer therapy in the treatment of bronchial asthma in children

Potapova

2022

Medicinskij sovet

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The review article presents an analysis of the data of foreign and domestic researchers characterizing the effectiveness of nebulizer therapy for bronchial asthma in children. The paper considers new data comparing the effectiveness of aerosol delivery devices. The advantage of inhalation therapy, which determines its widespread use in childhood, is its rapid delivery to the respiratory tract, high local and low systemic concentrations of the drug in target organs. Difficulties in observing the correct inhalation technique due to the difficulty of synchronizing inhalation and drug delivery, especially in young children, remain an urgent problem in the practice of treating chronic bronchopulmonary diseases, which leads to a severe and uncontrolled course, disability and adverse outcomes. The main disadvantage of ultrasonic nebulizers is the inactivation of suspensions, antibiotics and other drugs. Widely used jet nebulizers create noise during inhalation, have a large residual volume in the nebulizer chamber. In this regard, the improvement of delivery forms continues, taking into account the anatomical and physiological characteristics of the respiratory organs, the age of patients and comorbid conditions. The characteristics of the optimal inhaler include simplicity and ease of use, reliability, the possibility of effective inhalation of various drugs in combination with economical consumption. From this point of view, one of the universal means of transporting aerosols is membrane or electronic mesh (mesh) nebulizers, which provide excellent regional drug deposition in all age groups of children. The rapid achievement of clinical effect, compactness, mobility expand the possibilities of using mesh nebulizers at all levels of medical care.

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“…Particularly in the fields of pharmaceutical inhalation therapy, fuel injection and solid-state batteries, ultrasonic atomizers have great potential for application. For upper respiratory tract and pulmonary diseases, inhalation therapy allows direct access to the affected area, significantly reduces medicine dosage required, and reduces side effects and adherence compared to those of traditional oral and intravenous medicine administration [23] , [24] . For fuel injection atomization, ultrasonic atomization not only consumes less energy than conventional pressure atomization but also yields smaller atomized particles, thereby allowing the fuel to burn more fully and reducing the harm to the environment from combustion products.…”

Section: Introductionmentioning

confidence: 99%