<i>In Vitro</i> evaluation of effects of two ghanaian plants relevant to wound healing

Mensah, Abraham Yeboah; Houghton, Peter J.; Dickson, Rita A.; Fleischer, Theophilus C.; Heinrich, Michael; Bremner, Paul

doi:10.1002/ptr.1978

Cited by 64 publications

(48 citation statements)

References 15 publications

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“…The anti-inflammatory activity of the extract tested using the chick carrageenan-induced foot oedema model. [16]. It also demonstrated protection of MRC-5 cells against oxidation by reactive oxygen species [17].…”

Section: Introductionmentioning

confidence: 92%

Evaluation of central nervous system (CNS) depressant activity of methanolic extract of Commelina diffusa Burm. in mice

2018

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Background: Commelina diffusa Burm. (Family: Commelinaceae) is usually known as "climbing dayflower or spreading dayflower" in Bangladesh. The plant is used in fever, malaria, insect, bug bites, rheumatoid arthritis, gonorrhea, influenza, and bladder infection etc. The present investigation was undertaken which deals with the evaluation of central nervous system (CNS) depressant activity of methanolic extract of C. diffusa in mice models.

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Section: Introductionmentioning

confidence: 92%

Evaluation of central nervous system (CNS) depressant activity of methanolic extract of Commelina diffusa Burm. in mice

2018

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“…Some extrinsic factors are surgical technique, topical antiseptics and dressings 38 . Regarding wound dressings, several types have been developed based on plant herbs 39,40 , hydrocolloid, alginate and collagen 41 and can be applied as ointment, film 42 , foam and gel 43 for various purposes of treatment 44 . This manuscript reports on the development of a wound dressing for tissue repair based on bacterial cellulose and type I collagen.…”

Section: In Vivo Experimentsmentioning

confidence: 99%

Bacterial Cellulose/Collagen Hydrogel for Wound Healing

Moraes¹,

et al. 2016

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This study compares a wound dressing based on bacterial cellulose/collagen (BC/COL) hydrogel in rat dorsum with commercial collagenase ointment and untreated wound. The hydrogel was characterized by Scanning Electron Microscopy (SEM), Thermogravimetric Analysis (TGA), Fourier transformed -Infrared spectroscopy (FT-IR) and X-ray diffraction (XRD). According to the In vivo test and macroscopic evaluation, BC/COL hydrogel showed a better repair of wounds and promoted statistically significant differences of tissue repair between treatments on the 7th day after surgery. Better quality, quantity and orientation evaluation of collagen fibers (p=0.0001) were observed in the BC/COL hydrogel and collagenase ointment groups in relation to the control group. The BC/COL hydrogel promoted better wound healing than collagenase and the control group, therefore, it can be considered a potential wound dressing for skin regeneration.

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“…It is prepared as a poultice and applied to the affected part. Several plants popularly used as anti-snake venoms and for the management of spider bites and wounds exhibit anti-inflammatory activities (Lewis, 1989;Ruppelt et al, 1991;Ribeiro et al, 1988;Mensah et al, 2006). These references suggest the possibility that W. amplissima may also have anti-inflammatory activity.…”

Section: Introductionmentioning

confidence: 99%

ANTI-INFLAMMATORY AND ANTIOXIDANT ACTIVITIES OF THE LEAVES OF <i>WISSADULA AMPLISSIMA</i> VAR ROSTRATA

Mensah¹,

Donkor²,

Fleischer³

2011

Afr. J. Trad. Compl. Alt. Med.

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The present study determined the anti-inflammatory activity of Wissadula amplissima var rostrata (Schum. & Thonn.), and calculated the total phenolic content and total antioxidant capacity of the plant in an attempt to justify the traditional uses of the plant in the Ashanti region of Ghana for the management of spider,wasps and bee stings. Powdered dried leaves of Wissadula amplissima were Soxhlet extracted with Petroleum Ether (PWA, yield: 1.46% w / w ); Chloroform (CWA, yield: 1.18% w / w ) and Methanol (MWA, yield: 3.39% w / w ). These fractions were tested for anti-inflammatory activity using carrageenan-induced foot edema in 7 day old chicks. The effect before the induction of inflammation (pre-emptive protocol) paradigm was used for the assessment. Oral administration of PWA, CWA and MWA (30 -300 mg/kg) dose dependently reduced edema with maximal effects of 68.25±2.03%, 77.83±0.81% and 62.21±2.61% respectively. Similarly the NSAID, Diclofenac (10 -100 mg/Kg, i.p) and the steroidal anti-inflammatory drug dexamethasone (0.3 -3 mg/Kg, i.p) used as positive controls, dose-dependently inhibited the edema with maximal effect of 87.96±1.11% and 67.47±3.51% respectively. The potencies exhibited by all three extracts were comparable to that shown by Diclofenac but higher than that of Dexamethasone. Phenols were detected in all three extracts with the highest concentration in the MWA. The extracts also scavenged DPPH with EC 50 values of 0.9784, 0.9096 and 0.2767 for PWA, CWA, MWA respectively. The results of this study give scientific credence to the local use of Wissadula amplissima to modulate inflammation induced by stings of animals.

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In Vitro evaluation of effects of two ghanaian plants relevant to wound healing

Cited by 64 publications

References 15 publications

Evaluation of central nervous system (CNS) depressant activity of methanolic extract of Commelina diffusa Burm. in mice

Evaluation of central nervous system (CNS) depressant activity of methanolic extract of Commelina diffusa Burm. in mice

Bacterial Cellulose/Collagen Hydrogel for Wound Healing

ANTI-INFLAMMATORY AND ANTIOXIDANT ACTIVITIES OF THE LEAVES OF <i>WISSADULA AMPLISSIMA</i> VAR ROSTRATA

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