In-vitrofertilisation treatment: Factors affecting its results and outcome

Abstract

The objective of this study was to determine factors affecting results and outcome of in-vitro fertilisation (IVF). In this retrospective study, a total of 891 infertile women underwent IVF/ICSI cycles at the King Hussein Medical Center (KHMC) between January 2001 and December 2002. Conventional IVF treatment was performed in 64.6% of women and intracytoplasmic sperm injection (ICSI) in 35.4%, using a standardised long luteal protocol. Pregnancy rate was analysed according to age, type of infertility, cause of infertility, duration of infertility, number of eggs collected and follicle stimulating hormone (FSH) levels. A total of 126 cycles (14.1%) were cancelled. Among 765 cycles continued, fertilisation rate was 73.9%, implantation rate was 15.1% and pregnancy rate was 29.8%. Pregnant women had a multiple pregnancy rate of 28.9%, abortion rate of 13.6% and ectopic pregnancy rate of 1.3%. Duration and type of infertility had no significant effect on the pregnancy rate. Factors which appear to affect significantly the outcome of treatment include the woman's age, cause of infertility, basal concentrations of FSH, adequate ovarian responsiveness and the number of eggs collected. In some cases with poor outcome, the understanding of these factors may predict the results and lead to the development of new strategies to improve the outcome of IVF treatment.

Previous tubal ectopic pregnancy raises the incidence of repeated ectopic pregnancies in In Vitro fertilization-embryo transfer patients

“…This is a percentage of about 8.95% TEPs/pregnancies in comparison to IVF-ET cycles caused by other factors of infertility (0.75%/PR in our control group; 1.3% [14] up to 18.7%/PR [15] depending on the different assisting reproduction methods applied [16,17]). …”

Resultados de fertilização in vitro em mulheres submetidas previamente à laqueadura tubária

“…Contudo, no presente estudo, evidenciou-se que as pacientes previamente submetidas à laqueadura tubária com idade superior a 35 anos já apresentaram pior resposta à indução da ovulação do que as pacientes mais jovens, demonstrando que mulheres mais velhas apresentam menores probabilidades de obtenção de oócitos e implantação embrionária 19 . Apesar de a idade ser um fator que sabidamente afeta negativamente os resultados de tratamentos de infertilidade 20 , o achado do presente estudo defi ne um ponto de corte etário a partir do qual as pacientes previamente submetidas à laqueadura tubária apresentariam piores resultados na fertilização in vitro.…”

Thrombophilic Genes Mutations in Women with Repeated <i>In-Vitro</i> Fertilization Failure

“…About one-third of women undergoing will achieve an ongoing pregnancy (Qublan et al, 2005). Failure to achieve pregnancy implies failure of the pregnancy at implantation or at a time shortly thereafter.…”

“…Several factors have been recognized to affect either success or failure rate of IVF-embryo transfer. Such factors include age, parity, previously successful pregnancy, basal hormonal levels, number of antral follicles before stimulation; endometrial thickness, embryo grading, position and length of uterus and technique of embryo transfer (Qublan et al, 2005).…”