<i>In vitro</i> fertilization outcome in women with endometrial tuberculosis and tubal tuberculosis

Dai, Wen‐Rong; Ma, Linna; Cao, Yurong; Wu, Di; Yu, Ting; Zhai, Jing

doi:10.1080/09513590.2019.1702639

Cited by 15 publications

(21 citation statements)

References 14 publications

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“…Early identification of active TB cases and active anti-TB treatment are essential. However, the onset of TB is insidious, even without symptoms, and some patients may present with “infertility.” In vitro fertilization and embryo transfer (IVF-ET) remains the most effective method of treating associated infertility ( 5 ).…”

Section: Introductionmentioning

confidence: 99%

Impact of Positive Interferon-Gamma Release Assay on IVF-ET Pregnancy Outcomes in Infertile Patients With Untreated Prior Tuberculosis: A Prospective Cohort Study

et al. 2021

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Introduction: Tuberculosis (TB) is a major infectious disease that seriously endangers human health and female reproduction. In our previous study, 10.4% of infertile patients preparing for In vitro fertilization and embryo transfer (IVF-ET) had prior pulmonary TB (PTB) as detected on chest X-ray (CXR) screening. Among them, 81.8% did not receive anti-TB treatment. It remains unclear whether infertile women with untreated prior PTB have latent TB infection (LTBI) and whether LTBI affects IVF-ET outcomes. In this study, we aim to analyze the relationship between LTBI and pregnancy outcomes following IVF-ET in patients with untreated prior PTB.Methods and Analysis: We designed a prospective cohort study of 1,200 infertile women with CXR findings suggestive of old-healed untreated TB, who are preparing for IVF-ET. Patients with a history of active TB and anti-TB treatment will be excluded. Interferon-gamma release assay (IGRA) will be used in patients with CXR findings suggestive of old-healed untreated TB to construct a cohort of IGRA-positive and IGRA-negative patients. Participants will undergo IVF-ET. General information, including age, body mass index, infertility causes, and controlled ovarian hyperstimulation protocol, will be recorded. Participants will be followed up during pregnancy. The primary outcome is live birth. Secondary outcomes include the numbers of retrieved oocytes, high-quality embryo rate, clinical pregnancy, number of active TB cases during pregnancy, and miscarriage.Ethics and Dissemination: The study was approved by the Ethics Committee of Peking University Third Hospital [approval number (2020)218-01; approval date: June 19, 2020]. The research results will be disseminated through scientific/medical conferences and published in academic journals.Trial Registration:ClinicalTrials.gov; identifier: NCT04443283.

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Section: Introductionmentioning

confidence: 99%

Impact of Positive Interferon-Gamma Release Assay on IVF-ET Pregnancy Outcomes in Infertile Patients With Untreated Prior Tuberculosis: A Prospective Cohort Study

et al. 2021

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“…The use of IVF has long been recommended for genital TB [ 11 ]. However, IVF success is related to the site of damage caused by genital TB [ 12 ]. Dai et al conclusively pointed out that the prognosis is poorer when extensive endometrial damage is present compared to when there is only extensive tubal damage [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

Poor in vitro fertilisation outcomes in genital tuberculosis – Case report

Tjahyadi

Tjandraprawira

2022

Annals of Medicine &Amp; Surgery

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“… 39 Therefore, assisted reproductive technology (ART), such as in vitro fertilization and embryo transfer, remains the best choice for treating female infertility associated with tubal tuberculosis. 40 However, patients with endometrial TB show significantly reduced fertilization, implantation, and cumulative pregnancies. 40 A study reported the success rate of ART, in which the conception rate varied from 9% to 28%, and only <30% of the conceptions were normally delivered.…”

Section: Fgtb and Infertilitymentioning

confidence: 99%

“… 40 However, patients with endometrial TB show significantly reduced fertilization, implantation, and cumulative pregnancies. 40 A study reported the success rate of ART, in which the conception rate varied from 9% to 28%, and only <30% of the conceptions were normally delivered. 35 Furthermore, the rate of ectopic pregnancy was up to 10%, which indicated poor results even with ART.…”

Section: Fgtb and Infertilitymentioning

confidence: 99%

Emerging progress on diagnosis and treatment of female genital tuberculosis

Wang

Shao

et al. 2021

J Int Med Res

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Female genital tuberculosis (FGTB) is an infection caused by Mycobacterium tuberculosis and usually occurs secondary to pulmonary tuberculosis (TB) through the blood circulation, lymph circulation, or direct spreading from abdominal TB. FGTB is an uncommon type of TB that can destroy genital organs, and lead to menstrual disorders and infertility. The diagnosis of FGTB is often made by detection of acid-fast bacilli under microscopy, culture with endometrial biopsy, or histopathological examination of epithelioid granuloma on a biopsy. A multidrug anti-TB regimen is the major management of FGTB, including rifampicin, isoniazid, pyrazinamide, and ethambutol, while surgery is proposed in more deteriorated cases. However, the conception rate in infertile women with FGTB is still low, even after multidrug anti-TB therapy. Additionally, the risk of complications, such as ectopic pregnancy or miscarriage, remains high. In this review, we summarize the characteristics of FGTB, present current epidemiological data, and focus on its early diagnosis and effective management.

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In vitro fertilization outcome in women with endometrial tuberculosis and tubal tuberculosis

Cited by 15 publications

References 14 publications

Impact of Positive Interferon-Gamma Release Assay on IVF-ET Pregnancy Outcomes in Infertile Patients With Untreated Prior Tuberculosis: A Prospective Cohort Study

Impact of Positive Interferon-Gamma Release Assay on IVF-ET Pregnancy Outcomes in Infertile Patients With Untreated Prior Tuberculosis: A Prospective Cohort Study

Poor in vitro fertilisation outcomes in genital tuberculosis – Case report

Emerging progress on diagnosis and treatment of female genital tuberculosis

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