In VitroIncorporation of Radioiodinated Eugenol on Adenocarcinoma Cell Lines (Caco2, MCF7, and PC3)

Abstract

Recently, the synthesis of radiolabeled plant origin compounds has been increased due to their high uptake on some cancer cell lines. Eugenol (EUG), a phenolic natural compound in the essential oils of different spices such as Syzygium aromaticum (clove), Pimenta racemosa (bay leaves), and Cinnamomum verum (cinnamon leaf), has been exploited for various medicinal applications. EUG has antiviral, antioxidant, and anti-inflammatory functions and several anticancer properties. The objective of this article is to synthesize radioiodinated (I) EUG and investigate its effect on Caco2, MCF7, and PC3 adenocarcinoma cell lines. It is observed that radioiodinated EUG would have potential on therapy and imaging due to its notable uptakes in studied cells.

Green synthesis of silver nanoparticles by using eugenol and evaluation of antimicrobial potential

“…This peak was isolated from the whole extract, and purification of the peak was determinated by HPLC with the same isolation procedure. All HPLC chromatograms were uploaded as supplementary material . The isolated peak was sent to LC–MS analysis.…”

“…For instance, Dervis et al . synthesized AgNPs, and their characterization analysis showed that the size of AgNPs was between 25 and 50 nm and they have a cubic structure …”

“…Then, 30 g clove powder was dissolved with ethanol (100 ml) and mixed for 24 hr (50°C, 1100 rpm/min). The clove bud extract was obtained after removing ethanol by a rotary evaporator . HPLC analysis of clove bud extract was performed, and the selected peaks belonging to eugenol were isolated using a fraction collector of HPLC system according to the previous published article .…”

An Overview on the Anti‐inflammatory Potential and Antioxidant Profile of Eugenol

“…Several pharmacological activities have been reported to eugenol: anti-inflammatory [ 28 ], antitumor [ 29 ], antibacterial [ 30 ], antifungal [ 31 , 32 ], antipyretic [ 33 ], anesthetic [ 34 ], and analgesic activities [ 35 ]. Considering the importance of eugenol as bioactive molecule and its presence in various foods and medicinal plants, this review discusses its role in the inflammatory response in experimental models, including animals and cell culture tests, demonstrating its antioxidant profile and potential therapeutical application against inflammatory diseases.…”

Eugenol triggers CD11b+Gr1+myeloid-derived suppressor cell apoptosisviaendogenous apoptosis pathway

“…21 Eugenol has extensive pharmacological effects, such as inhibiting the NF-kB pathways, participating in immune regulation and the anti-inammatory response, blocking the activity of xanthine oxidase, affecting temperaturesensitive neuron discharge and antipyretic activities. [22][23][24][25][26] Moreover, eugenol is used for animal anaesthesia, mosquito repellent and the promotion of drug permeation absorption. Eugenol shows potential for application in the prevention and treatment of certain tumours.…”