<i>In Vitro</i>Repair of Single–strand Breaks in γ-irradiated DNA by Polynucleotide Ligase

Jacobs, Anita; Bopp, Annemarie; Hagen, U.

doi:10.1080/09553007214551321

Cited by 37 publications

(2 citation statements)

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“…Simple or single enzyme DNA repair systems ( Figure 3 ) range from insertases that reinsert missing bases and ligases that seal nicks to alkyltransferases and dioxygenases that deal with large adducts and light-dependant photolyases that break bonds formed between adjacent nucleotides of the same strand ( Jacobs et al, 1972 ; Livneh and Sperling, 1981 ; Eker et al, 2009 ; Rastogi et al, 2010 ). Complex DNA repair systems ( Figure 3 ) are multi-enzyme pathways involving cutting and rejoining of the DNA backbone.…”

Section: Dna Repair – An Overviewmentioning

confidence: 99%

DNA Repair Repertoire of the Enigmatic Hydra

2021

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Since its discovery by Abraham Trembley in 1744, hydra has been a popular research organism. Features like spectacular regeneration capacity, peculiar tissue dynamics, continuous pattern formation, unique evolutionary position, and an apparent lack of organismal senescence make hydra an intriguing animal to study. While a large body of work has taken place, particularly in the domain of evolutionary developmental biology of hydra, in recent years, the focus has shifted to molecular mechanisms underlying various phenomena. DNA repair is a fundamental cellular process that helps to maintain integrity of the genome through multiple repair pathways found across taxa, from archaea to higher animals. DNA repair capacity and senescence are known to be closely associated, with mutations in several repair pathways leading to premature ageing phenotypes. Analysis of DNA repair in an animal like hydra could offer clues into several aspects including hydra’s purported lack of organismal ageing, evolution of DNA repair systems in metazoa, and alternative functions of repair proteins. We review here the different DNA repair mechanisms known so far in hydra. Hydra genes from various DNA repair pathways show very high similarity with their vertebrate orthologues, indicating conservation at the level of sequence, structure, and function. Notably, most hydra repair genes are more similar to deuterostome counterparts than to common model invertebrates, hinting at ancient evolutionary origins of repair pathways and further highlighting the relevance of organisms like hydra as model systems. It appears that hydra has the full repertoire of DNA repair pathways, which are employed in stress as well as normal physiological conditions and may have a link with its observed lack of senescence. The close correspondence of hydra repair genes with higher vertebrates further demonstrates the need for deeper studies of various repair components, their interconnections, and functions in this early metazoan.

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Section: Dna Repair – An Overviewmentioning

confidence: 99%

DNA Repair Repertoire of the Enigmatic Hydra

2021

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“…. The mechanism of direct rejoining of DNA strand breaks (Friedberg, 1985) involves a single enzyme, polynucleotide (DNA) ligase (Dean and Pauling, 1970;Grecz et al, 1983;Jacobs et al, 1972), which directly rejoins the 5'-P04 and 3'-OH termini of a broken strand (Lewin, 1983). This rejoining appears to occur very shortly (30-40 sec) after introduction of the break and is impaired in the presence of oxygen (Grecz et al, 1983).…”

Section: Sos Response)mentioning

confidence: 99%

Sensitivity of Listeria to irradiation in raw ground meat, as affected by type of radiation, product temperature, packaging atmosphere, and recovery medium

Tarté

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Pathogenesis of Listeria monocytogenes 52 Epidemiology of foodbome listeriosis 55 Listeria monocytogenes in foods and the environment 59 Elimination of Listeria monocytogenes by Food Irradiation 61 References 66 CHAPTER 3. SURVIVAL AND INJURY OF LISTERIA MONOCYTOGENES, LISTERIA INNOCUA AND LISTERIA IVANOVIim GROUND PORK FOLLOWING ELECTRON BEAM IRRADIATION Abstract 79 CHAPIER 4. SENSITIVITY OF LISTERU MONOCYTOGENES TO IRRADL^TION IN GROUND BEEF AS AFFECTED BY TYPE OF RADIATION (X-RAYS OR ELECTRONS

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Effects of Ionizing Radiation on Mammalian Cells

Little

Williams

1977

Comprehensive Physiology

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The sections in this article are: Physical and Chemical Events Development of Radiation Injury The Target Theory Direct and Indirect Effects, Radiation Chemistry Effects on Cell Division Division Delay Mitotic Inhibition (Reproductive Failure) Radiation Sensitivity in Different Phases of the Life Cycle Chromosomal Damage Interphase Death Nonlethal Heritable Changes Biological Variation in Radiation Sensitivity Mechanisms Modification of Radiation Effects Physical Factors Chemical Radiation Protection and Sensitization Oxygen Effect Intracellular Recovery Processes Repair of Potentially Lethal Damage Repair of Sublethal Damage (Split‐Dose Recovery) Molecular Repair Processes Damage Observed in DNA Cellular Repair Systems for DNA Damage Repair Activities in Mammalian Cells Correlation of DNA Repair with Biological Effects Concluding Remarks Addendum

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In VitroRepair of Single–strand Breaks in γ-irradiated DNA by Polynucleotide Ligase

Cited by 37 publications

References 10 publications

DNA Repair Repertoire of the Enigmatic Hydra

DNA Repair Repertoire of the Enigmatic Hydra

Sensitivity of Listeria to irradiation in raw ground meat, as affected by type of radiation, product temperature, packaging atmosphere, and recovery medium

Effects of Ionizing Radiation on Mammalian Cells

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