In vivoandin vitropharmacological activity ofAristolochia tagala(syn:Aristolochia acuminata) root extracts

Battu, Ganga Rao; Parimi, Ravi; Shekar, K.B. Chandra

doi:10.3109/13880209.2011.589855

Cited by 21 publications

(16 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The petroleum ether, ethyl acetate, and ethanol extracts of Aristolochia tagala Cham. root, traditionally used for rheumatic pain and fever treatment, investigated the anti‐inflammatory activity and confirm the traditional indications of this plant . Also, the roots of A tagala were used in Thai traditional medicine as antipyretic, anti‐inflammatory agent, muscle relaxant, appetite‐enhancing agent, and analeptic …”

Section: Introductionmentioning

confidence: 88%

“…The methanol extract of A bracteolata had significant antidiabetic and hypolipidemic activity. 19 The petroleum ether, ethyl acetate, and ethanol extracts of Aristolochia tagala Cham. root, traditionally used for rheumatic pain and fever treatment, investigated the anti-inflammatory activity and confirm the traditional indications of this plant.…”

Section: For This Reason Plants Have a Very Important Place In Medicmentioning

confidence: 99%

“…root, traditionally used for rheumatic pain and fever treatment, investigated the anti-inflammatory activity and confirm the traditional indications of this plant. 19 Also, the roots of A tagala were used in Thai traditional medicine as antipyretic, anti-inflammatory agent, muscle relaxant, appetite-enhancing agent, and analeptic. 20 Aristolochia species have been reported to date that aristolochic acid, aristolactam, alkaloid, sesquiterpene, sterol, and essential oil have been found in their studies.…”

Section: For This Reason Plants Have a Very Important Place In Medicmentioning

confidence: 99%

“…20 Aristolochia species have been reported to date that aristolochic acid, aristolactam, alkaloid, sesquiterpene, sterol, and essential oil have been found in their studies. 21,22 It has been determined that this Aristolochia plant, which has been widely used in pharmacological studies, has important biological activities such as antioxidant, 17,23 antibacterial, 16,24 anticancer, 13,16 anti-inflammatory, 15,17,19 and antidiabetic 14,18 activities.…”

Section: For This Reason Plants Have a Very Important Place In Medicmentioning

confidence: 99%

“…methanol extract in the diabetic rat model of streptozotocin. The methanol extract of A bracteolata had significant antidiabetic and hypolipidemic activity . The petroleum ether, ethyl acetate, and ethanol extracts of Aristolochia tagala Cham.…”

Section: Introductionmentioning

confidence: 97%

See 4 more Smart Citations

An investigation of chemical content, enzyme inhibitory propert, antioxidant and antibacterial activity of Aristolochia bodamae Dingler (develiotu) (Aristolochiaceae) root extracts from Samsun, Turkey

Özen

Bora

Yenigun

et al. 2019

Flavour & Fragrance J

View full text Add to dashboard Cite

The present work aimed to evaluate the phytochemical contents of the methanol (ME), ethanol (ET), water (W), acetone (AC), ethyl acetate (EA), and hexane (HE) of Aristolochia bodamae root (ABR) as well as inhibition potential, antioxidative, and antimicrobial activities. The chemical composition analysis and antioxidant activity of ABR extracts were performed by commonly used assays. Antibacterial activities of ABR extracts were tested against three gram‐positive and three gram‐negative bacteria using disk diffusion and microdilution methods. The inhibition potential of the extract was adopted for urease and esterases. The extraction yield (27.10%), total phenolic (47.53 mg gallic acid equivalent/g), and flavonoid (9.74 mg quercetin equivalent/g) content of ABRME were found higher than other extracts. Vanillic acid, caffeic acid, epicatechin, p‐coumaric acid, ferulic acid, and protocatechuic acid were recognized as major components. ABRET, ABRHE, and ABREA extracts had a more effective total antioxidant activity than that of other extracts. The lipid peroxidation inhibition, H2O2, and superoxide scavenging activities of ABRME were found to be 35.94, 35.94, and 3.98 µg/mL, respectively. The ABRET exhibited a reduction force with the A0.5 values of 48.77 µg/mL. The inhibition levels of ABRAC and ABREA to esterases were determined to be more effective than galantamine. ABRME was identified as a more potent urease inhibitor (IC50: 188.42 µg/mL) than thiourea. ABRET demonstrated the antibacterial activity with the highest inhibition zone of 14.4 mm against Staphylococcus aureus. The ABRET found the lowest MIC value against Bacillus cereus (128 µg/mL). In these in vitro studies, it has been found that ABR extracts were a good source of antioxidant, antibacterial, and inhibition potent when evaluated together with phenolic components.

show abstract

Section: Introductionmentioning

confidence: 88%

Section: For This Reason Plants Have a Very Important Place In Medicmentioning

confidence: 99%

Section: For This Reason Plants Have a Very Important Place In Medicmentioning

confidence: 99%

Section: For This Reason Plants Have a Very Important Place In Medicmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

See 3 more Smart Citations

An investigation of chemical content, enzyme inhibitory propert, antioxidant and antibacterial activity of Aristolochia bodamae Dingler (develiotu) (Aristolochiaceae) root extracts from Samsun, Turkey

Özen

Bora

Yenigun

et al. 2019

Flavour & Fragrance J

View full text Add to dashboard Cite

show abstract

In vitro antiviral activities of ethanol and aqueous extracts of Vietnamese traditional medicinal plants against Porcine Epidemic Diarrhea virus: a coronavirus family member

Trinh

Nguyen

et al. 2021

VirusDis.

View full text Add to dashboard Cite

Porcine epidemic diarrhea virus (PEDV) causes diarrhea in pigs leading to severe illnesses and high mortality rates. The development of medicinal agents to treat PEDV infection is therefore crucial. In this study, antiviral activities against PEDV of ethanol and aqueous extracts of 17 Vietnamese traditional medicinal plants were evaluated using the cytopathic effect-based assay. The results showed that 14 out of 17 medicinal plants could inhibit the cytopathic effect of PEDV. The ethanol extract of Stixis scandens was identified as the most active extract with its MIC (minimum inhibitory concentration) being 0.15 lg/ mL. Other plant extracts also displayed strong antiviral activity against PEDV, including Anisomeles indica, Pericampylus glaucus and Croton kongensis. The results demonstrate that certain medicinal plants have a high antiviral potential and may serve as a lead to develop novel pharmaceutical agents to cure PED as well as the diseases caused by other coronaviruses.

show abstract

Evaluation of Antimycobacterial Activity of Higenamine Using Galleria mellonella as an In Vivo Infection Model

Kazyoba

Omolo

Sunguruma

et al. 2018

Nat. Prod. Bioprospect.

View full text Add to dashboard Cite

The Phytochemical investigation on MeOH extract on the bark of Aristolochia brasiliensis Mart. & Zucc (Aristolochiaceae) led to the isolation of major compound (1) as light brown grainy crystals. The compound was identified as 1-(4-hydroxybenzyl)-1,2,3,4-tetrahydroisoquinoline-6,7-diol (higenamine) on the basis of spectroscopic analysis, including 1D and 2D NMR spectroscopy. The compound was evaluated for its antimycobacterial activity against Mycobacterium indicus pranii (MIP), using Galleria mellonella larva as an in vivo infection model. The survival of MIP infected larvae after a single dose treatment of 100 mg/kg body weight of higenamine was 80% after 24 h. Quantitatively the compound exhibited a dose dependent activity, as evidenced by the reduction of colony density from 105 to 103 CFU for test concentrations of 50, 100, 150 and 200 mg/kg body weight respectively. The IC50 value for higenamine was 161.6 mg/kg body weight as calculated from a calibration curve. Further analysis showed that, a complete inhibition of MIP in the G. mellonella could be achieved at 334 mg/kg body weight. Despite the fact that MIP has been found to be highly resistant against isoniazid (INH) in an in vitro assay model, in this study the microbe was highly susceptible to this standard anti-TB drug. The isolation of higenamine from the genus Aristolochia and the method used to evaluate its in vivo antimycobacterial activity in G. mellonella are herein reported for the first time.

show abstract

In vivoandin vitropharmacological activity ofAristolochia tagala(syn:Aristolochia acuminata) root extracts

Abstract: These findings demonstrate that the A. tagala roots have excellent anti-inflammatory activity and validate the traditional indications of this plant in its origin country.

Cited by 21 publications

References 6 publications

An investigation of chemical content, enzyme inhibitory propert, antioxidant and antibacterial activity of Aristolochia bodamae Dingler (develiotu) (Aristolochiaceae) root extracts from Samsun, Turkey

An investigation of chemical content, enzyme inhibitory propert, antioxidant and antibacterial activity of Aristolochia bodamae Dingler (develiotu) (Aristolochiaceae) root extracts from Samsun, Turkey

In vitro antiviral activities of ethanol and aqueous extracts of Vietnamese traditional medicinal plants against Porcine Epidemic Diarrhea virus: a coronavirus family member

Evaluation of Antimycobacterial Activity of Higenamine Using Galleria mellonella as an In Vivo Infection Model

Contact Info

Product

Resources

About