<i>In vivo</i>antinociceptive and anti-inflammatory activities of umbelliferone isolated from<i>Potentilla evestita</i>

Khan, Rahmat Ullah; Khan, Haroon; Pervez, Samreen; Pirzada, Abdul Saboor

doi:10.1080/14786419.2014.901317

Cited by 39 publications

(20 citation statements)

References 15 publications

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“…Previous investigators displayed the anti-inflammatory properties of Umb (24,25). Ji et al also proved that Flu inhibited the inflammatory conditions in UCMS-induced depressivelike behavior (26).…”

Section: Discussionmentioning

confidence: 96%

Retracted: Umbelliferone reverses depression-like behavior in chronic unpredictable mild stress-induced mice via RIP140/NF-κB pathway

Kong

Long

et al. 2016

IUBMB Life

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Section: Discussionmentioning

confidence: 96%

Retracted: Umbelliferone reverses depression-like behavior in chronic unpredictable mild stress-induced mice via RIP140/NF-κB pathway

Kong

Long

et al. 2016

IUBMB Life

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“…The Umbelliferae family is inclusive of economically important herbs, such as celery, cumin, fennel, parsley alexanders, angelica, asafoetida, and giant hogweed [9,170]. UMB possesses a variety of bioactivities, and several investigators have previously reported its in vivo antioxidant and anti-inflammatory effects and studied the underlying mechanisms of action in several animal models [30,[171][172][173][174][175]. The anticancer activity of UMB in hepatocellular [176], colon [177], and oral [178] carcinomas has been well-acknowledged.…”

Section: Urolithin Amentioning

confidence: 99%

Coumarins as Modulators of the Keap1/Nrf2/ARE Signaling Pathway

Hassanein

Sayed

Hussein

et al. 2020

Oxidative Medicine and Cellular Longevity

164

106

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The Keap1/Nrf2/ARE system is a central defensive mechanism against oxidative stress which plays a key role in the pathogenesis and progression of many diseases. Nrf2 is a redox-sensitive transcription factor controlling a variety of downstream antioxidant and cytodefensive genes. Nrf2 has a powerful anti-inflammatory activity mediated via modulating NF-κB. Therefore, pharmacological activation of Nrf2 is a promising therapeutic strategy for the treatment/prevention of several diseases that are underlined by both oxidative stress and inflammation. Coumarins are natural products with promising pharmacological activities, including antioxidant, anticancer, antimicrobial, and anti-inflammatory efficacies. Coumarins are found in many plants, fungi, and bacteria and have been widely used as complementary and alternative medicines. Some coumarins have shown an ability to activate Nrf2 signaling in different cells and animal models. The present review compiles the research findings of seventeen coumarin derivatives of plant origin (imperatorin, visnagin, urolithin B, urolithin A, scopoletin, esculin, esculetin, umbelliferone, fraxetin, fraxin, daphnetin, anomalin, wedelolactone, glycycoumarin, osthole, hydrangenol, and isoimperatorin) as antioxidant and anti-inflammatory agents, emphasizing the role of Nrf2 activation in their pharmacological activities. Additionally, molecular docking simulations were utilized to investigate the potential binding mode of these coumarins with Keap1 as a strategy to disrupt Keap1/Nrf2 protein-protein interaction and activate Nrf2 signaling.

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“…Toxicology Research Accepted ManuscriptPublished on17 June 2015. Downloaded by Dalhousie University on 20/06/2015 06:26:37. value of UFG for DPPH and ABTS free radicals.…”

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confidence: 99%

Umbelliferone β-d-galactopyranoside inhibits chemically induced renal carcinogenesis via alteration of oxidative stress, hyperproliferation and inflammation: possible role of NF-κB

et al. 2015

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Umbelliferone (7hydroxycoumarin) compound possesses strong anti-inflammatory and free radical scavenging activity. The intend of the current study was to conclude the renalprotective efficacy of Umbelliferone β-D-galactopyranoside (UFG) over diethylinitrosamine (DEN) initiated and ferric nitrilotriacetate (Fe-NTA) promoted the oxidative stress, inflammation and renal injury in Wistar rats. The capacity of UFG to scavenge the reactive nitrogen species (RNS) and reactive oxygen species (ROS) was evaluated and its also scrutinized scavenging against the hydroxyl (OH), superoxide (O 2 ), nitric acid (NO) and hydrogen peroxide (H 2 O 2 ) radicals. Renal carcinoma was induced by single intraperitoneal injection of DEN (200 mg/kg, b.w.) and promoted by twice weekly treatment of Fe-NTA (9 mg/kg, b.w.) for 22 weeks. To estimated the molecular mechanism implicated in the antitumor potential of UFG, its consequence was appraised on renal tumor inflammation; proinflammatory cytokines including interleukin-1β (IL-1β), interlukin-6 (IL-6) and tumor necrosis factor (TNF-α); inflammatory mediator including prostaglandin E 2 (PGE 2 ), ornithine decarboxylase (ODC) and nuclear factor kappa B cell (NFκB). It's also induced the serum abnormability including creatinine, lactate dehydrogensae (LDH) blood urea nitrogen (BUN) and [ 3 H] thymidine incorporation. Further, augments the renal lipid peroxidation (LPO), endogenous antioxidant enzymes, phase II metabolizing enzymes and concomitant reduction in glutathione (GSH). UFG showed the 95% and 99% antioxidant activity in 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) and 2, 2-diphenyl-1-picrylhydrazyl (DPPH) model. UFG significantly inhibited the RNS and ROS radical and 2 indicated the antioxidant activity (in vitro). The results showed momentous renal markers and oxidative stress protection impaired by UFG. UFG also restored the altered inflammatory and proinflammatory cytokines, which further strengthens the renal protection of UFG in DEN+Fe-NTA induced renal carcinogenesis. These results recommend that UFG as an efficient chemoprotective agent having the ability to thwart the DEN induced and Fe-NTA promoted renal carcinoma in experimental rats.

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In vivoantinociceptive and anti-inflammatory activities of umbelliferone isolated fromPotentilla evestita

Cited by 39 publications

References 15 publications

Retracted: Umbelliferone reverses depression-like behavior in chronic unpredictable mild stress-induced mice via RIP140/NF-κB pathway

Retracted: Umbelliferone reverses depression-like behavior in chronic unpredictable mild stress-induced mice via RIP140/NF-κB pathway

Coumarins as Modulators of the Keap1/Nrf2/ARE Signaling Pathway

Umbelliferone β-d-galactopyranoside inhibits chemically induced renal carcinogenesis via alteration of oxidative stress, hyperproliferation and inflammation: possible role of NF-κB

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