2017
DOI: 10.1080/10717544.2017.1378938
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In vivo antitumor effect of endostatin-loaded chitosan nanoparticles combined with paclitaxel on Lewis lung carcinoma

Abstract: The purpose of this study was to prepare endostatin-loaded chitosan nanoparticles (ES-NPs) and evaluate their antitumor effect when combined with paclitaxel (PTX) on Lewis lung carcinoma (LLC) mouse xenografts. ES-NPs were prepared by ionic cross-linking. Characterization of the ES-NPs included size distribution, drug-loading efficiency (DL), and encapsulation efficiency (EE). An in vitro release test was also used to determine the release behavior of the ES-NPs. A subcutaneous LC xenograft model of C57BL/6J m… Show more

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Cited by 35 publications
(23 citation statements)
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“…The lung tumor xenografts were randomly assigned to eight groups (n = 10 each): 0.9% saline control, P solution (10 mg/kg), T solution (6 mg/kg), P/T solution (5 mg/kg of PTX and 3 mg/kg of TL), blank LPNs, P-LPNs (10 mg/kg), T-LPNs (6 mg/kg), and P/T-LPNs (5 mg/kg of PTX and 3 mg/kg of TL) were administered intravenously every other day for 18 days. 37 Mice were sacrificed by cervical dislocation on day 20, and the tumor tissues were collected for further analysis. During the treatment, tumor size (length and width) was measured using calipers every 4 days.…”
Section: Methodsmentioning
confidence: 99%
“…The lung tumor xenografts were randomly assigned to eight groups (n = 10 each): 0.9% saline control, P solution (10 mg/kg), T solution (6 mg/kg), P/T solution (5 mg/kg of PTX and 3 mg/kg of TL), blank LPNs, P-LPNs (10 mg/kg), T-LPNs (6 mg/kg), and P/T-LPNs (5 mg/kg of PTX and 3 mg/kg of TL) were administered intravenously every other day for 18 days. 37 Mice were sacrificed by cervical dislocation on day 20, and the tumor tissues were collected for further analysis. During the treatment, tumor size (length and width) was measured using calipers every 4 days.…”
Section: Methodsmentioning
confidence: 99%
“…To confirm NP coating with both peptides, authors used DLS, evaluating afterwards the differences in activity (Lee et al, 2004 ). Also targeting tumors, iron oxide NPs coated with an heptapeptide that recognize fibrin-fibronectin complexes or chitosan NPs with antiangiogenic peptide endostatin (ES) improved anticancer activity by targeting the vascularization of the tumor (Agemy et al, 2010 ; Xie et al, 2017 ). Coating nanoparticle surfaces with two or more different peptides was also reported (Colombo et al, 2002 ; Marchiò et al, 2004 ).…”
Section: Nanoparticles In Therapeuticsmentioning
confidence: 99%
“…This vasculature can be characterized by disorganization, dilation, branching, shunts, and varied diameters that result in an inconsistent blood flow and hypoxic areas and regions of high acidity [35,36] . As previously reported, a lower MVD is related to slower tumor growth and improved biologic and clinical behavior [37][38][39][40] . Mice in the Ab+ Bi+ RT group showed the lowest expression of CD-31 and Ki-67 compared to mice in other groups.…”
Section: Dsbsmentioning
confidence: 74%