<i>In vivo</i>/<i>in silico</i> insight into the effect of titanium dioxide nanoparticle on serum paraoxonase 1 activity in rat

Mortazavi, Hessameddin; Omidi-Ardali, Hossein; Amini, Seyed Asadollah; Saffari-Chaleshtori, Javad; Samani, Keihan Ghatreh

doi:10.1080/07391102.2020.1864662

Cited by 4 publications

(1 citation statement)

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“…One of these xenobiotics is metallic NPs, where several studies demonstrated placental transfer of NPs in rodents e.g. gold NPs (AuNPs) [ 5 ], oxide-bused particles, fullerenes (C60), carbon-black and titanium dioxide NPs (TiO2NPs) [ 6 ], and fluorescent quantum dots (QDs) [ 7 ]. This study was designated to explore the accumulation levels and excretion of AgNPs in organs and body fluids in both mothers and fetuses in relation to their placental transfer.…”

Section: Introductionmentioning

confidence: 99%

Tissue distribution, placental transfer and excretion of silver nanoparticles in pregnant rats after a single oral dose

Abdel-Halim,

Salim,

Abdel-Latif

et al. 2023

Environ Anal Health Toxicol

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A quantitative assessment of silver nanoparticles (AgNPs) in fluids and some organs of pregnant rats as well as their fetal blood were carried out in this study. A single oral dose (1mg/kg) of AgNPs with a size range of 4-20 nm was administered to pregnant rats on the 19th of gestation. Five groups were euthanized after 10 min, 1, 6, 12, and 24 hr as well as the control group. Total Silver (Ag) contents were measured in bloods (maternal and fetal) and several organs using Inductive Coupled Plasma Optical Emission Spectroscopy (ICP-OES) followed by acid digestion. In maternal blood, AgNPs were found to increase time-dependently after 12 and 24 hr into 0.135 and 0.224 μg/ml, but it was slightly higher in fetal blood (0.32 and 0.31 μg/ml) after 10 min and 1 hr. In other samples: kidneys, liver, spleen, placenta, and uterus the data indicated that NPs were rapidly absorbed from the dosing site (gastrointestinal tract) as evidenced by the detection of Ag in the analyzed samples (fluids and tissues). On the other hand, the cumulative percentages of excretion level in urine was 8.25% which was higher than in feces (4.77%) after 24 hr. These findings indicate the ability of AgNPs to accumulate in pregnant rats and transfer to their fetus imposing adverse outcomes and male formation. Thus, further investigations must be followed for direct and/or indirect exposure to such NPs before decision for their practices.

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Section: Introductionmentioning

confidence: 99%