In vivo inhibitory effects of arjunolic acid derivatives on two‐stage carcinogenesis in mouse skin

Abstract

In a previous study, arjunolic acid (1) isolated from Cochlospermum tinctorium and its hemisynthetic derivatives 2,3 and 4 were shown to exhibit in uitro inhibitory effects on Epstein-Barr virus (EBV) activation. Compounds 3 and 4, which showed the strongest inhibitory activities, were further prepared from arjunolic acid isolated fromMifragym ciliaria; they were tested in uiuo on a two-stage carcinogenesis assay in mouse skin, using dimethylbenz[a]anthracene (DMBA) as initiator and 12-0-tetradecanoylphorbol-13-acetate (TPA) as promoter. The activities were evaluated by both rate (YO) of papilloma-bearing mice and average number of papillomas per mouse and compared with the control. In the group of mice treated with 3 and 4, the Occurrence of papillomas was delayed, compared with the results of the control; with derivative 4, papillomas Occurred in 100% animals only at week 15. These results suggest that arjunolic acid derivatives could be valuable compounds as antitumour-promoters.

Inhibitory Effects of Lanostane-Type Triterpene Acids, the Components of <i>Poria cocos</i>, on Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate in Two-Stage Carcinogenesis in Mouse Skin

“…Other triterpenes have been reported to inhibit tumor promotion in two-stage carcinogenesis in mouse skin [11][12][13][14][23][24][25]. Many triterpenes, widely distributed in plant and fungi, inhibit the tumor-promoting activity of TPA in mice, and this suggests that they may be of importance in the prevention of cancer.…”

Self assembled arjunolic acid acts as a smart weapon against cancer through TNF- α mediated ROS generation

“…So it can assumed that SA-AA a liposome like nano organic substance easily fused with cells and rapidly entered in to the cell trigger c-Jun N-terminal Kinase pathway [44] which elevated the TNF-α makes ROS generation ultimately causing the nuclear damage and membrane bubbling and damage leads to cancer cell death [45].…”

Inhibitory Effect of Taraxastane-Type Triterpenes on Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate in Two-Stage Carcinogenesis in Mouse Skin

“…Other triterpenes were reported to inhibit tumor pro motion in two-stage carcinogenesis in mouse skin [1][2][3][4][5][7][8][9]. In order to screen new inhibitors for use as chemopreventive agents, we deliberately chose nontoxic com pounds, among which taraxasterol and faradiol were revealed to be a potential inhibitor of tumor promotion.…”

“…Various tripcrpenes have been demonstrated by us [1][2][3][4][5] and by other workers [6][7][8][9] to inhibit the tumor-pro moting activity of 12-O-tetradecanoylphorbol-13-acetate (TPA) in two-stage carcinogenesis in mouse skin. Recent ly, it was reported that faradiol (taraxast-20-ene-3p,16p-diol), a taraxastane-type triterpene, from the flowers of Calendula officinalis (Compositae) exhibited marked anti-inflammatory activity on the croton oil-induced der matitis of the mouse ear [10,11].…”