<i>In vivo</i> reflectance confocal microscopy of equivocal melanocytic lesions detected by digital dermoscopy follow‐up

Lovatto, Louise; Carrera, Cristina; Salerni, Gabriel; Alós, Llúcia; Malvehy, Josep; Puig, Susana

doi:10.1111/jdv.13067

Cited by 59 publications

(58 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…8,19 Several studies have demonstrated that focal dermoscopic structural changes are significantly associated with melanoma, however; it remains extremely difficult to differentiate changing atypical nevi from early melanoma via dermoscopy. 20 …”

Section: Role Of Reflectance Confocal Microscopy In Detecting Melanommentioning

confidence: 99%

“…8 If RCM is added as another investigative layer, approximately 70% of the excisions of changing or equivocal nevi could potentially be avoided without decreasing the sensitivity for melanoma detection. 20,21 Table 1 summarizes the RCM features used to help differentiate melanoma from nevi. The main RCM features associated with melanoma include the presence of roundish pagetoid cells, atypical cells at the basal layer, non-edged papilla, and nucleated atypical cells within the dermis.…”

Section: Role Of Reflectance Confocal Microscopy In Detecting Melanommentioning

confidence: 99%

See 1 more Smart Citation

Discriminating Nevi from Melanomas

Carrera

Marghoob

2016

Dermatologic Clinics

View full text Add to dashboard Cite

Section: Role Of Reflectance Confocal Microscopy In Detecting Melanommentioning

confidence: 99%

Section: Role Of Reflectance Confocal Microscopy In Detecting Melanommentioning

confidence: 99%

Discriminating Nevi from Melanomas

Carrera

Marghoob

2016

Dermatologic Clinics

View full text Add to dashboard Cite

“…However, 8% of monitored lesions excised due to change are benign [70]. RCM can be used as an adjunct in atypical melanocytic lesions exhibiting changes on digital dermoscopy follow-up to further improve diagnostic accuracy of melanoma [17,19,71]. Lovatto et al .…”

Section: Background: Reflectance Technologymentioning

confidence: 99%

“…Lovatto et al . retrospectively evaluated the impact of RCM evaluation in melanocytic lesions exhibiting changes on digital dermoscopy surveillance [17]. In a series of 64 lesions (13 MIS, 5 SSM, 51 benign nevi), confocal microscopy analysis showed a sensitivity and specificity of 100 and 69%, respectively, for the diagnosis of melanoma and could have avoided excision of 35 of 51 benign nevi.…”

Section: Background: Reflectance Technologymentioning

confidence: 99%

Advances in the use of Reflectance Confocal Microscopy in Melanoma

2018

View full text Add to dashboard Cite

In vivo reflectance confocal microscopy (RCM) is a noninvasive high-resolution skin imaging tool that has become an important adjunct to clinical exam, dermoscopy and histopathology assessment, in the diagnosis and management of melanoma. RCM generates a horizontal view of the skin, whereby cellular and subcellular (e.g., nuclei, melanophages, collagen) structures, to the level of the upper dermis, are projected onto a screen at near-histological resolution. Morphologic descriptors, standardized terminology, and diagnostic algorithms are well established for the RCM assessment of melanoma, melanocytic, and nonmelanocytic lesions. Clinical applications of RCM in melanoma are broad and include diagnosis, assessment of large lesions on cosmetically sensitive areas, directing areas to biopsy, delineating margins prior to surgery, detecting response to treatment and assessing recurrence. This review will provide an overview of RCM technology, findings by melanoma subtype, clinical applications, as well as explore the accuracy of RCM for melanoma diagnosis, pitfalls and emerging uses of this technology ex vivo.

show abstract

“…Dermatologists diagnose MM according to ABCDE rule (asymmetry, border, color, diameter, and evolution). The major disadvantage of these two types of methods is the heavily dependence on the expertise and training of the dermatologist [14,15]. Due to this fact, this method causes high rate of false positive alarms.…”

Section: Introductionmentioning

confidence: 99%

Optical configuration of pigmented lesion detection by frequency analysis of skin speckle patterns

Bishitz¹,

Ozana²,

Schwarz³

et al. 2016

Biomed. Opt. Express

View full text Add to dashboard Cite

Abstract:In this paper we present a novel approach of realizing a safe, simple, and inexpensive sensor applicable to pigmented lesions detection. The approach is based on temporal tracking of back-reflected secondary speckle patterns generated while illuminating the affected area with a laser and applying periodic pressure to the surface via a controlled vibration source. When applied to pigmented lesions, the technique is superior to visual examination in avoiding many false positives and resultant unnecessary biopsies. Applying a series of different vibration frequencies at the examined tissue and analyzing the 2-D time varying speckle patterns in response to the applied periodic pressure creates a unique signature for each and different pigmented lesion. Analyzing these signatures is the first step toward detection of malignant melanoma. In this paper we present preliminary experiments that show the validity of the developed sensor for the classification of pigmented lesions.

show abstract

In vivo reflectance confocal microscopy of equivocal melanocytic lesions detected by digital dermoscopy follow‐up

Cited by 59 publications

References 27 publications

Discriminating Nevi from Melanomas

Discriminating Nevi from Melanomas

Advances in the use of Reflectance Confocal Microscopy in Melanoma

Optical configuration of pigmented lesion detection by frequency analysis of skin speckle patterns

Contact Info

Product

Resources

About